Metabolic Network
Comparative Analysis of Salmonella Genomes Identifies a Metabolic Network for Escalating Growth in the Inflamed Gut
... large metabolic network that likely epitomizes the “winning strategy” employed by members of the gastrointestinal pathovar to edge out competing microbes in the lumen of the inflamed gut, thereby enhancing ...
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Influence of metabolic network structure and function on enzyme evolution
... yeast metabolic network relate to earlier work on protein interaction networks? There, a similar relationship between protein connectivity and evolutionary constraint has been suggested [4,5]; however, this ...
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Using Topology of the Metabolic Network to Predict Viability of Mutant Strains
... determining network function and malfunction [11, 12]. We employ a novel network property, synthetic accessibility, an intuitive and transparent way of understanding the effects of metabolic mutation ...
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Constructing a fish metabolic network model
... fish metabolic network model because a) a combined model will be more useful for other under-represented fish species; b) genome annotations are far from perfect - combining five genome sequences will ...
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MIRAGE: a functional genomics based approach for metabolic network model reconstruction and its application to cyanobacteria networks
... the network is expected to be able to ...possible metabolic routes [29], aiming to identify a mini- mal number of missing reactions to fulfill the required ...for network reconstruction that is based ...
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Integrating kinetic model of E coli with genome scale metabolic fluxes overcomes its open system problem and reveals bistability in central metabolism
... It is understood that the genes governing the expression and production of Icl and Mals enzymes undergo catabolite repression under our conditions of interest [53]. One could thus assume their activities to be inactive, ...
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The transferome of metabolic genes explored: analysis of the horizontal transfer of enzyme encoding genes in unicellular eukaryotes
... and metabolic network connectivity The idea that genes of related function might be co-trans- ferred was ...is, metabolic network adjacency relationships corresponding to enzymes that catalyze ...
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Flux balance analysis accounting for metabolite dilution
... genome-scale metabolic network model of ...1,260 metabolic genes, 2,382 reactions and 1,668 ...available metabolic nutrients in each medium ...
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KEGG spider: interpretation of genomics data in the context of the global gene metabolic network
... global metabolic network [22,23], providing, how- ever, no quantitative or statistical ...bolic network give only an intuitive feeling that genes are ...of metabolic net- works, one must not ...
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A. The Overview of Plasmodium falciparum
... reconstructed metabolic network and identifies 10 essential reactions that are common to all existing literature of which all this reaction were validated to be essential by our ...a metabolic ...
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TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei
... Many additional databases provide information that can complement metabolic network databases. Linking to these other data sources enhances our ability to learn about an organism’s metabolism. TrypanoCyc, ...
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Synthesis and Enzymatic Studies of Selenium Derivatized Nucleosides, Nucleotides and Nucleic Acids
... the metabolic pathway data and modeled them as directed ...the metabolic networks, which take into account the similarity of network topology and the enzymes’ ...for metabolic network ...
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Short term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long term viability
... the metabolic network ...given metabolic reaction. c A metabolic network model showing integration of metabolic and transcriptomic ...
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TrypanoCyc : a community led biochemical pathways database for Trypanosoma brucei
... Many additional databases provide information that can complement metabolic network databases. Linking to these other data sources enhances our ability to learn about an organism’s metabolism. TrypanoCyc, ...
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Metabolic network as a progression biomarker of premanifest Huntington’s disease
... rate, network activity values were computed on an individual basis in metabolic scans from a separate longitudinal cohort of gene carriers, designated HD3 (Figure 1 and Supplemental Table ...groups, ...
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Predicting genes for orphan metabolic activities using phylogenetic profiles
... orphan metabolic activities by using gene phylogenetic pro- ...structed metabolic network (for example, giving more weight to genes closer to a network gap) our method is able to com- bine the ...
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Bistability in a Metabolic Network Underpins the De Novo Evolution of Colony Switching in Pseudomonas fluorescens
... and metabolic in- termediates) surrounding the bifurcation of the UTP pool into CTP and ...a metabolic pathway where a single, inevitably limiting resource is partitioned into two or more components, there ...
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Metabolic network driven analysis of genome wide transcription data from Aspergillus nidulans
... the metabolic network we identified several multi-enzyme complexes (for example, the F 0 F 1 ATP synthase complex or the pyruvate dehydrogenase complex, which consist of several different proteins), and we ...
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TrypanoCyc: a community led biochemical pathways database for Trypanosoma brucei
... T. brucei cells contain multiple membrane-bounded or- ganelles, including the mitochondrion and an unusual peroxisome-related organelle, the glycosome (25,26), in which the first seven steps of glycolysis occur, as well ...
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Identifying primary care patients at risk for future diabetes and cardiovascular disease using electronic health records
... measured metabolic syndrome traits, in the frame- work of case finding in a broad population of usual care patients where some missing data are ...using metabolic syndrome defined as having three or more ...
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