metabolic phenotype
Alteration of myocardial GRK2 produces a global metabolic phenotype
... WAT from TgβARKct mice shows increased expression of genes related to adipose differentiation and function. A particularly striking aspect of the metabolic phenotype in our transgenic mice is the rapid ...
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The carnitine status does not affect the contractile and metabolic phenotype of skeletal muscle in pigs
... Noteworthy, the fiber distribution of a given muscles shows high plasticity and can be induced to switch depend- ing on various factors, like exercise, mechanical unloading and obesity, thereby leading to a change of the ...
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The impact of the metabolic phenotype on thyroid function in obesity
... the metabolic phenotype remained sig- nificant after adjustment for potential ...obese phenotype, while fT4 levels act as a proxy of the metabolic status related to the obese ...sex, ...
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Timing of Calorie Restriction in Mice Impacts Host Metabolic Phenotype with Correlative Changes in Gut Microbiota
... During the 4-week CR period, the CRL and CRD mice exhibited a decrease in body weight compared to the NC mice, but the CRL mice lost significantly more weight than did the CRD mice (Fig. 1c). By the end of the 4-week CR, ...
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A nuclear-directed human pancreatic ribonuclease (PE5) targets the metabolic phenotype of cancer cells
... During the past decade, cancer metabolism has emerged as one of the most exciting and promising fields for the development of selective anticancer therapies. The development of cancer metabolism inhibitors and their ...
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Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs
... carbohydrate phenotype (Figure 3), over-expression of dilp2 alone can rescue the growth and hemolymph carbohydrate phenotypes due to early ablation of the mNSCs ...
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Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21.
... To examine metabolic effects of MR before the effects on body weight, mice were fed MR or control diet for 48 h. After 48 h, there was no change in body weight (Fig. 6A), but serum levels of FGF21 were ...
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HIV 1 pathogenicity and virion production are dependent on the metabolic phenotype of activated CD4+ T cells
... Because cells grown in galactose are mostly dependent on oxidative phosphorylation for their metabolic needs, we considered that this might impact on their sensitivity to oxidative stress. The generation of ...
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Maternal transmission of Alzheimer's disease: Prodromal metabolic phenotype and the search for genes
... After advanced age, having a parent affected with Alzheimer’s disease (AD) is the most significant risk factor for developing AD among cognitively normal (NL) individuals. Although rare genetic mutations have been ...
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The metabolic phenotype of rodent sepsis: cause for concern?
... Limitations of our study include an inability to directly reproduce the study design in both rodent species. We did initially use a tether system and vascular instrumentation under anaesthesia to enable continuous ...
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Global testing of shifts in metabolic phenotype
... We explored Goeman’s global testing approach (Hen- drickx et al. 2012; Goeman et al. 2004) to assess the effect of the WL and PP intervention on both fasting (at T0) and mixed meal challenge responses. Originally the ...
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The ratio of skeletal muscle mass to visceral fat area is a main determinant linking circulating irisin to metabolic phenotype
... correlated with BMI, waist circumference, fasting glucose, HbA1c, total cholesterol, triglyceride, LDL cholesterol, and HOMA-IR in subjects without metabolic syndrome. However, these correlations did not exist in ...
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The prevalence of the metabolically healthy obese phenotype in an aging population and its association with subclinical cardiovascular disease: The Brazilian study on healthy aging
... one metabolic risk factor, which may limit the ability of employing risk factors alone in an attempt to stratify population into different risk ...MHO phenotype within this population; however, failed to ...
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<p>Objective diagnosis of post-stroke depression using NMR-based plasma metabonomics</p>
... The metabolic phenotype homogeneity between ischemic and hemorrhagic subjects, major PSD and minor PSD Subjects were assessed separately by OPLS-DA ...
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Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism
... experimental groups were compared to non-pooled con- trols. All data shown represent new cohorts of mice al- though some of the metabolic phenotype of TSCmKO mice have been published before [14]. The fact ...
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Endocannabinoid tone is higher in healthy lean South Asian than white Caucasian men
... of metabolic disease, such as obesity and ...develop metabolic disease; however, the underlying mechanism remains to be elu- ...disadvantageous metabolic phenotype have higher circulating ...
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The "Ins and Outs" of Sleep: How Internal Metabolic and External Environmental Signals Affect the Sleep Process
... central metabolic pathways – such as the tricarboxylic acid (TCA) cycle – to generate ...of metabolic risk and suggest that neurological disorders caused by altered glutamate or GABA may be associated with ...
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The ER alpha mutation Y537S confers Tamoxifen resistance via enhanced mitochondrial metabolism, glycolysis and Rho GDI/PTEN signaling : implicating TIGAR in somatic resistance to endocrine therapy
... hyper-active metabolic phenotype, characterized by high levels of OXPHOS and mitochondrial biogenesis, as well as elevated levels of glycolysis (Figure ...quantitative metabolic flux analysis, ...
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Honor Thesis_Jinglin Ji.pdf
... for metabolic phenotype, including measures of fasting blood glucose and insulin, are widely utilized in diagnosis of diabetes in human patients and are good approximates of the diabetogenic effect of iAs ...
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The Liver X Receptor (Lxr) Governs Lipid Homeostasis in Zebrafish during Development
... lipid metabolic pathways ...with metabolic diseases, in particular atherosclerosis, and with various retinal disease conditions while cholesterol deficiency is associ- ated with developmental abnormalities ...
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