Metastatic spread
Primary Sites of Gastric Carcinoma with Metastatic Spread Detected by Transabdominal Hydrosonography: Experience of 76 Cases in Bangladesh
... Background: Metastasis is frequently occurred among the gastric carcinoma pa- tients. Objectives: The purpose of the present study was to detect the different pri- mary sites of gastric carcinoma by ultrasonography with ...
7
Gene expression modules in primary breast cancers as risk factors for organotropic patterns of first metastatic spread: a case control study
... of metastatic breast cancer is a complex multi-step process manifesting with diverse temporal patterns involving single or multiple organs ...with metastatic breast cancer is 18 to 24 months, although the ...
15
Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer
... Third, the most direct evidence for a functional role of ADAMTS19 hypermethylation is the observed pheno- typic changes after downregulation of its expression. This proves that silencing is not inconsequential. How- ...
15
Suppression of the metastatic spread of breast cancer by DN10764 (AZD7762)-mediated inhibition of AXL signaling
... early metastatic steps, such as cancer cell adherence to the vascular endothelium and ...of metastatic spread in the intracardiac metastasis ...
11
Gene expression modules in primary breast cancers as risk factors for organotropic patterns of first metastatic spread: a case control study.
... expression in frozen breast tumours as a molecular risk factor for metastatic spread.. 18 ER-positive/HER2-negative or high grade tumours, and make use of appropriate platform[r] ...
37
Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models
... The 4T1 and 67NR models have been useful for examin- ing the impact of FGFR inhibition on tumor growth and metastatic spread [9]. We previously showed that blocking FGFR in vitro was sufficient to inhibit ...
16
Circulating tumor cells as early predictors of metastatic spread in breast cancer patients with limited metastatic dissemination
... Systemic metastatic spread represents the main cause of breast cancer–related morbidity and ...of metastatic burden, and length of disease-free interval, often do not adequately predict treatment ...
9
CGB and GNRH1 expression analysis as a method of tumor cells metastatic spread detection in patients with gynecological malignances
... Background: Metastasis is a common feature of many advanced stage cancers and metastatic spread is thought to be responsible for cancer progression. Most cancer cells are localized in the primary tumor and ...
9
Host JDP2 expression in the bone marrow contributes to metastatic spread
... The c-Jun Dimerization Protein 2, JDP2, is a basic leucine zipper protein member of the activator protein-1 (AP-1) family of transcription factors. JDP2 typically suppresses gene transcription through multiple mechanisms ...
13
Mathematical modelling of cancer invasion and metastatic spread
... As briefly explained in Section 2.3, cancer cells adapt to the environmental requirements of the various steps of the invasion-metastasis cascade via changes in phenotype (Jolly et al., 2017). EMT and MET are a canonical ...
215
Metastatic spread in patients with gastric cancer
... Two sources were used for identifying metastatic spread. The National Patient Register includes all hospitalizations in Sweden, with nationwide coverage since 1987, and reporting is obligatory from all ...
10
A mathematical framework for modelling the metastatic spread of cancer
... can spread to distant secondary sites in the ...as metastatic spread, is responsible for around 90% of deaths from cancer and is one of the so-called hallmarks of ...the metastatic process, we ...
46
Gallein, a Gβγ subunit signalling inhibitor, inhibits metastatic spread of tumour cells expressing OR51E2 and exposed to its odorant ligand
... We then explored the potential inhibitory effect of gallein on the in vivo β-ionone-induced metastasis spread. Cas- trated male NSG mice carrying subcutaneous injected LNCaP cells were exposed to cutaneous ...
6
Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs OXPHOS and prostate cancer metastatic spread
... Cancer associated fibroblasts (CAFs) are key determinants of cancer progression. In prostate carcinoma (PCa), CAFs induce epithelial-mesenchymal transition (EMT) and metabolic reprogramming of PCa cells towards oxidative ...
14
Basal oxidative stress ratio of head and neck squamous cell carcinomas correlates with nodal metastatic spread in patients under therapy
... In this study, we observed a strong correlation between the levels of oxidized and reduced GSH in tumor tissues and the nodal status of the head and neck cancer patients. A lower GSSG/GSH ratio was observed in tumor ...
5
Expression of Chemokine Receptor CXCR4 in Primary and Metastatic Neuroblastoma Expression of CXCR4 in Neuroblastoma
... these metastatic sites were shown to express a chemokine receptor; ...to metastatic sites rich in stromal cell-derived factor-1 ...and metastatic clinical samples of ...increased metastatic ...
7
Treatment of Liver Metastases from Neuroendocrine Tumours in Relation to the Extent of Hepatic Disease
... Methods: A novel classification of LM from NET was established based on their localization and presentation. Results: From 1992 to 2006, 119 patients underwent staging and treatment of LM. Three growth types of LM were ...
11
Prognostic factors of melanoma patients with satellite or in-transit metastasis at the time of stage III diagnosis
... first metastatic spread, including patients with synchronous lesions already present at the time of initial diagnosis, stage I/II patients with loco-regional recurrence and patients initially presenting ...
6
Nodal skip metastasis in thoracic esophageal squamous cell carcinoma: a cohort study
... a) metastatic involve- ment of distant LNs with peritumoral LNs free of tumor infiltration [12, 16, 18,], b) cervical and/or abdominal in- volvement but no mediastinal metastasis [14, 15, 19], or c) ...
7
<p>Sentinel lymph node biopsy in the management of conjunctival melanoma: current insights</p>
... The goal of sentinel lymph node biopsy (SLNB), in general, is to detect putative subclinical micrometastases in the regional lymph nodes which otherwise escape detection by ultrasound imaging and clinical examina- tion. ...
6