MHC class I antigen
Expression of class I and class II major histocompatibility antigens on human hepatocellular carcinoma
... express class I MHC antigens and among them, three poorly differentiated human HCC cell lines also express class II MHC ...the class I and class II MHC ...
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Mutanome and expression of immune response genes in microsatellite stable colon cancer
... the antigen presentation machinery were also ...the antigen processing ...the antigen presentation machinery with ...via MHC class I antigen presentation, directly related ...
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The genotype of the transporter associated with antigen processing gene affects susceptibility to colorectal cancer in Japanese
... in antigen presentation mediated by MHC class I and this process is considered essential for immune surveillance against tumors and ...of class I molecules on the cell surface is ...
6
Characterization of a diverse secretome generated by the mouse preimplantation embryo in vitro
... the MHC class I antigen ...(MHC class I) antigen in determining the embryo's rate of growth [35], it will be an ...
10
Evidence for Antibody-Mediated Enhancement of Simian Immunodeficiency Virus (SIV) Gag Antigen Processing and Cross Presentation in SIV-Infected Rhesus Macaques
... Animals. The six adult rhesus macaques utilized herein as a source of periph- eral blood mononuclear cells (PBMC) were part of a separate study but were chosen because they were positive for the Mamu-A01 MHC ...
15
Virus-Like Particles as Carriers for T-Cell Epitopes: Limited Inhibition of T-Cell Priming by Carrier-Specific Antibodies
... enous antigen to reach the major histocompatibility complex (MHC) class I ...the MHC class II pathway while only endogenous antigens efficiently fuel the MHC class ...
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Selective deletion of antigen-specific CD8(+) T cells by MHC class I tetramers, coupled to the type I ribosome-inactivating protein saporin
... Primary T cells cultured in vitro also can die from neglect, and it is possible that SAP-coupled tetramers caused the death of cognate T cells simply by providing inadequate stimulation through the TCR. To exclude this ...
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Mouse Norovirus Infection Reduces the Surface Expression of Major Histocompatibility Complex Class I Proteins and Inhibits CD8+ T Cell Recognition and Activation
... (MHC) class I proteins, which present viral antigen to immune ...the antigen presentation pathway in infected cells by reducing the surface expression of MHC class ...
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Altered Expression of TAP-1 and Major Histocompatibility Complex Class I in Laryngeal Papillomatosis: Correlation of TAP-1 with Disease
... with antigen presentation (TAP-1) and the major histocompatibility complex (MHC) class I protein expression in laryngeal papilloma tissue biopsies and cell culture of primary ...lating ...
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Association of CD99 short and long forms with MHC class I, MHC class II and tetraspanin CD81 and recruitment into immunological synapses
... and antigen presenting cells, and is characterized by lipid and protein segregation, signaling compartmentali- zation, and bidirectional information exchange through soluble and membrane-bound transmitters ...
13
Virotheranostics, a double-barreled viral gun pointed toward cancer; ready to shoot?
... APCs: Antigen present- ing cells; NK: Natural killer; MHC-I: Major histocompatibility complex class-I; CTL: Cytotoxic T-lymphocytes; PRRs: Pattern recognition receptors; SPECT: Sin- ...
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Organizational Accessibility and Community Connections: Examining Changes in the Spatial Proximity of Pubic Housing Residents to Social Service Providers and Providers' Responses to Redevelopment
... accomplish this, we exposed infected cells to PBMC at 50:1 effector: target ratio and deter-‐ mined NK cell cytotoxicity by measuring perforin and granzyme B release. Generally, NK cell (during primary infection) and ...
150
Polymer nanoparticles for cross-presentation of exogenous antigens and enhanced cytotoxic T-lymphocyte immune response
... released antigen was processed by the proteasome and presented by MHC class I molecules via a classical endogenous antigen-presentation ...
12
Expression, purification and characterization of ricin vectors used for exogenous antigen delivery into the MHC class I presentation pathway
... Disarmed versions of the cytotoxin ricin can deliver fused peptides into target cells leading to MHC class I-restricted antigen presentation [Smith et al. J Immunol 2002; 169:99- 107]. The ...
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A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells
... of MHC I heavy chain and β2-microglubulin in bacteria, refolding with a desired peptide, purification, biotinylation, and multimerization (Altman et ...peptide– MHC I complex, because empty ...
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Posttranscriptional Inhibition of Class I Major Histocompatibility Complex Presentation on Hepatocytes and Lymphoid Cells in Chronic Woodchuck Hepatitis Virus Infection
... of class I MHC, chronic disease, independent of the severity of liver injury and the duration of chronicity, is uniformly associated with a de- crease in the expression of these molecules similar to ...
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The Major Histocompatibility Complex Class I Genes of Zebrafish.
... than antigen presentation to CD8 + T ...nonclassical MHC class I molecules can carry out functions such as specialized antigen presentation, IgG transport, or immunoregulation via ...
156
Bhonsle, Latika (2012): Characterization of potentially autoaggressive brain infiltrating CD8+ T cells in multiple sclerosis patients. Dissertation, LMU München: Fakultät für Biologie
... Candidate antigen screening is however restricted by the availability of the original HLA-matched antigen presenting ...on MHC class I molecules (Ackerman and Cresswell ...correct ...
174
Presentation of intracellular antigen with MHC class II molecules
... expressing MHC class I (all nucleated cells) can process and present antigen to cytotoxic T ...ature MHC class I molecules are heterodim ers m ade u p of a glycosylated a ...
235
In vitro analysis of a primary, major histocompatibility complex (MHC)-restricted, cytotoxic T-lymphocyte response to avian leukosis virus (ALV), using target cells expressing MHC class I cDNA inserted into a recombinant ALV vector.
... ALV-specific, MHC-restricted, CD8 1 CTLs were demon- strated in PBMCs from chickens inoculated with ...of MHC-compatible target cells caused by the insertion of spe- cific class I MHC ...
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