MHC class I epitopes
Proteasome-Independent Major Histocompatibility Complex Class I Cross-Presentation Mediated by Papaya Mosaic Virus-Like Particles Leads to Expansion of Specific Human T Cells
... MHC class I cross-presentation mediated by PapMV VLPs is proteasome ...generate epitopes recognized by T cells, and for MHC class I epitopes, classical processing ...
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Dendritic Cells Restore CD8+ T Cell Reactivity to Autologous HIV-1
... predicted MHC class I affinity of known or predicted epitope variants and IFN- ␥ pro- ...experimental MHC class I affinities and multiple time points in disease progression ...
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COVID-19 Vaccine Candidates by Identification of B and T Cell Multi-Epitopes Against SARS-COV-2
... of MHC-I (47 alleles) and MHC- II (27 set alleles) with high ...all epitopes was developed as a publicly available epitope database ...any class of HLA 1 and HLA 2 all over the ...
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Arthritogenic T cell epitope in glucose 6 phosphate isomerase induced arthritis
... (MHC) class II (I-Aq) from DBA/1 mice was identified from the amino acid sequence of T cell epitopes and candidate peptides of T cell epitopes in GPI- induced arthritis were ...
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Investigating immune responses to parasites using transgenesis
... either MHC class II or ...with MHC class II. In contrast, OT-I mouse express a transgene encoding a TCR spe- cific for a short peptide fragment of OVA (amino acids 257–264) presented by ...
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Virus-Like Particles as Carriers for T-Cell Epitopes: Limited Inhibition of T-Cell Priming by Carrier-Specific Antibodies
... (LCMV)-derived MHC class I-restricted pep- tide p33 (23) or MHC class II-restricted peptide p13 ...(MHC class I) and p13 (MHC class II) in vitro and ...
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Immunoinformatics screening of prospective mhc class i restricted cytotoxic t-cell based epitopes in zika virus
... candidate epitopes show their binding potency towards this allele as evident from Table ...selected epitopes with HLA-A*0201 considering mouse H-2Kb-restricted peptide VSV8 (RGYVYQGL) (Tsukahara et ...
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Use of recombinant protein to identify a motif-negative human cytotoxic T-cell epitope presented by HLA-A2 in the hepatitis C virus NS3 region.
... (CTL) epitopes, the common approach involving the use of a series of overlapping synthetic peptides covering the whole protein sequence is impractical for large ...of epitopes. To identify human CTL ...
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Gag-specific cytotoxic T lymphocytes from human immunodeficiency virus type 1-infected individuals: Gag epitopes are clustered in three regions of the p24gag protein.
... In this report we investigate the number of T-cell epitopes in the Gag protein that are recognized by CTL from a sample of HIV-1-infected individuals with MHC class I polymorphisms that [r] ...
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Investigating and Manipulating Major Histocompatibility Complex (MHC) Class I-Restricted Peptide Epitopes and Cognate T-cell Responses.
... complex class I (MHCI) molecules are restrictive elements for responses by natural killer (NK) and cluster of differentiation (CD)8+ T cells, which are cytotoxic immune cell effectors that assist in the ...
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Bordetella pertussis Proteins Dominating the Major Histocompatibility Complex Class II-Presented Epitope Repertoire in Human Monocyte-Derived Dendritic Cells
... cell epitopes may help to increase our understanding of the ba- sis of cell-mediated immune mechanisms to control this reemerging ...(MHC) class II-presented B. pertussis CD4 ⴙ T cell ...
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Novel epitope based peptides for vaccine against SARS-CoV-2 virus: immunoinformatics with docking approach
... B-cell epitopes, 10 MHC class I binding T-cell peptides and 6 MHC class II binding T- cell peptides that are all conserved potential epitopes that might serve as potential ...
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Immunoinformatics-Guided Designing of an Epitope-Based Vaccine Against Severe Acute Respiratory Syndrome-Coronavirus-2 Spike Glycoprotein
... showed MHC class I interaction ...the MHC class I alleles, and WTAGAAAYY interacted with the most MHC class I ...the epitopes including WTAGAAAYY, ...
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Proximity ligation assay evaluates IDH1R132H presentation in gliomas
... assess MHC binding of putative or known immunogenic epitopes, in silico binding algorithms such as NetMHC or SYF- PEITHI have been established ...vitro class I– and class II–binding ...
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In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate
... four MHC classes I and II puta- tive epitopes within the ...present MHC class I and II epitopes should be prior- itized given the mounting evidence that antigen-specific ...
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Association of CD99 short and long forms with MHC class I, MHC class II and tetraspanin CD81 and recruitment into immunological synapses
... CD99 is expressed as two distinct isoforms, a long 32 kDa form (type I) and a short 28 kDa form (type II) resulting from an alternative splicing process of the pro- duct of the encoding gene [22]. In the immune ...
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A Novel Bat Herpesvirus Encodes Homologues of Major Histocompatibility Complex Classes I and II, C-Type Lectin, and a Unique Family of Immune-Related Genes
... Analysis of individual genes and gene families. (i) Proteins essential for DNA replication and nucleotide metabolism. Like other betaherpesviruses (52, 59, 77, 78), MsHV encodes the ho- mologues of the six genes ...
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Immunogenicity of Peptides Bound to MHC Class I Molecules Depends on the MHC-Peptide Complex Stability
... To study the relation between dissociation of peptides bound to MHC class I molecules and their ability to induce a CTL response, we used nine peptides derived from HBV[r] ...
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Posttranscriptional Inhibition of Class I Major Histocompatibility Complex Presentation on Hepatocytes and Lymphoid Cells in Chronic Woodchuck Hepatitis Virus Infection
... and antisense degenerative primers 2M-plus (5⬘-ATGKCTCGCTCSGTGRCC) and 2M-minus (5⬘-TTACATGTCTCGRTCCCAS), respectively. The wood- chuck TAP1 sequence was amplified with sense primer APT-1 (5⬘-TTCTTY ACRGGCCGCMTCACTGAC) ...
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DNMT1 regulates expression of MHC class I in post-mitotic neurons
... S2. MHC-I gene expression was evaluated using probes against HLA-A , HLA-B and HLA-C in human SK-N-AS neuroblastoma cell line, and for mouse cells using probes against β2-microglobulin (β2M) , H2-D1 , H2-K1 ...
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