MHC Class I Gene
Transcription variants of SLA 7, a swine non classical MHC class I gene
... (MHC) class I gene family comprises classical (Ia) and non classical (Ib) ...polymorphic class Ia genes are widely expressed and encode membrane-bound glyco- proteins that present self ...
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Transcriptional Changes Induced by Bovine Papillomavirus Type 1 in Equine Fibroblasts
... used gene expression profiling as a screening tool to identify candidate genes implicated in disease ...pathogenesis. Gene expression profiles of equine fibroblasts transformed by BPV-1 experimentally or ...
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Identification of the mouse cytomegalovirus genomic region affecting major histocompatibility complex class I molecule transport.
... respective gene products block the transport of nascent MHC class I molecules (12, ...nascent MHC class I heavy chains after DNA injec- tion, namely, the requirement of IE ...
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Characterization of a Murine Cytomegalovirus Class I Major Histocompatibility Complex (MHC) Homolog: Comparison to MHC Molecules and to the Human Cytomegalovirus MHC Homolog
... the gene prior to the predicted trans- membrane region (following residue 241 of the mature pro- ...hb2m gene in order to facilitate detection of the protein product with the antibody ...
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Lessons from viral manipulation of protein disposal pathways
... viral gene products has revealed a multitude of strategies employed by viruses to escape from innate and adaptive host defense ...of MHC class I molecules and other surface molecules, all of ...
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DNMT1 regulates expression of MHC class I in post-mitotic neurons
... TaqMan® Gene Expression Assays probes (Additional file 1: Table S2) were from LifeTechnologies (Applied Biosystems, Foster City, CA, United ...TaqMan® Gene Expression Master Mix (Applied Biosys- tems, ...
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Evolution of MHC class I genes in the European badger (Meles meles)
... and gene conversion on sequence evolution are similar in small se- quence fragments, therefore we did not differentiate between them, and we refer to them as recombination sensu lato here- after (Richman et ...
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Direct recognition of hepatocyte-expressed MHC class I alloantigens is required for tolerance induction
... genomes. Gene transfer to recipient liver using AAV vectors is an emerging ther- apy for the induction of antigen-specific tolerance (16), which could be of significant benefit in the setting of clinical organ and ...
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The Missing Link in Epstein-Barr Virus Immune Evasion: the BDLF3 Gene Induces Ubiquitination and Downregulation of Major Histocompatibility Complex Class I (MHC-I) and MHC-II
... of MHC class II molecules and gp42 in EBV infection, and also the observation that BDLF3 knockout EBV particles can infect epithelial cells better than B cells (18), we can propose a potential role for ...
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A Novel Bat Herpesvirus Encodes Homologues of Major Histocompatibility Complex Classes I and II, C-Type Lectin, and a Unique Family of Immune-Related Genes
... encode MHC class I homologues, and 3 to encode MHC class II homologues; 4 encode the homologues of C-type lectin- or natural killer cell lectin-like receptors;, and the products of a ...
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Association of CD99 short and long forms with MHC class I, MHC class II and tetraspanin CD81 and recruitment into immunological synapses
... CD99 is expressed as two distinct isoforms, a long 32 kDa form (type I) and a short 28 kDa form (type II) resulting from an alternative splicing process of the pro- duct of the encoding gene [22]. In the ...
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Posttranscriptional Inhibition of Class I Major Histocompatibility Complex Presentation on Hepatocytes and Lymphoid Cells in Chronic Woodchuck Hepatitis Virus Infection
... CD3 gene, whose transcripts are specific for T lymphocytes, primers CD3P (5⬘-CTGGGACTCTGCCTCTTATC) and CD3M (5⬘-GCTGGCCTTTC CGGATGGGCTC), with sequences essentially identical to those reported by others (38), were ...
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Expression of m157, a Murine Cytomegalovirus-Encoded Putative Major Histocompatibility Class I (MHC-I)-Like Protein, Is Independent of Viral Regulation of Host MHC-I
... DNase I (Invitrogen) per the manufacturer’s protocol and reverse transcribed with oligo (dT) prim- ers using the Advantage RT-for-PCR kit (BD ...early gene), m152 (the early gene), m157, and HPRT ...
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The MHC class I–like Fc receptor promotes humorally mediated autoimmune disease
... Gene-expression profiling. To minimize sample preparation variation, all samples were processed in parallel. Contralateral popliteal LNs from the same mice used for flow-cytometric analysis were collected into ...
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Rapid Evolution of Major Histocompatibility Complex Class I Genes in Primates Generates New Disease Alleles in Humans via Hitchhiking Diversity
... macaque MHC class I region: One bacterial artificial chromosome (BAC) library, CHORI-250, constructed from white blood cells of the male rhesus macaque was obtained from the BACPAC Resource Center at ...
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Possible Assortment of a1 and a2 Region Gene Segments in Human MHC Class I Molecules
... human MHC class I molecules, we have constructed triangular tables to study the similarities and differences of various a1 (exon 2) and a2 (exon 3) region ...known MHC class I ...
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Structural and Functional Dissection of Human Cytomegalovirus US3 in Binding Major Histocompatibility Complex Class I Molecules
... E3/19K gene product (E19), al- though there is no amino acid sequence homology between ...type I transmembrane glycoproteins featuring a short cytoplasmic tail and a bulky luminal ...the MHC ...
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Processing and Presentation of Murine Cytomegalovirus pORFm164-Derived Peptide in Fibroblasts in the Face of All Viral Immunosubversive Early Gene Functions
... the MHC-peptide complex is presented at the cell ...m152 gene product gp37/40 as the molecule responsible for retention of IE1 pep- tide-loaded MHC class I complexes in the ER and ...
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Downregulation of MHC class I molecules by human cytomegalovirus-encoded US2 and US11
... different MHC class I locus ...the class I heavy chains that are important for binding to US11, or that determine their sensitivity to US11-mediated dislocation and degradation have not ...
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Direct Binding of Human Immunodeficiency Virus Type 1 Nef to the Major Histocompatibility Complex Class I (MHC-I) Cytoplasmic Tail Disrupts MHC-I Trafficking
... complex class I molecules (MHC-I) and CD4 and CD28 cell surface ...on MHC-I have been shown to protect infected cells from cytotoxic T-lymphocyte recognition by downmodulation of ...
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