MHC Class II Gene
DEK binding to class II MHC Y box sequences is gene and allele specific
... in MHC class II gene promoters pointed to the Y box as one possible related ...the MHC class II gene Y box anchors a complex assembly of nuclear proteins that ...
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The gentle art of gene arrangement: the meaning of gene clusters
... the class III region of the MHC, such as TNF, could compensate for over- reaching immunostimulatory effects of the products of some of the class I or class II alleles alongside which ...
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The Missing Link in Epstein-Barr Virus Immune Evasion: the BDLF3 Gene Induces Ubiquitination and Downregulation of Major Histocompatibility Complex Class I (MHC-I) and MHC-II
... of MHC class II molecules and gp42 in EBV infection, and also the observation that BDLF3 knockout EBV particles can infect epithelial cells better than B cells (18), we can propose a potential role ...
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A Novel Bat Herpesvirus Encodes Homologues of Major Histocompatibility Complex Classes I and II, C-Type Lectin, and a Unique Family of Immune-Related Genes
... specific gene expression profiles in response to specific pathogens ...type II trans- membrane proteins resembling C-type lectins, for which there is accumulating evidence to support crucial roles in the ...
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Major Histocompatibility Complex Variation in the Endangered Przewalski’s Horse
... many MHC genes is thought to play an essential role in recognition of ...different class II DRB major histocompatibility ...one gene (although one sequence codes for a nonfunctional allele ...
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Tumor-specific CD4 T cells eradicate myeloma cells genetically deficient in MHC class II display
... Air-1 gene in MOPC315 or J558 cells treated as in (A), plotted relative to expression in J558 cells treated with 10 nM Trichostatin A (fold ...of MHC class II expression (MFI) on wild type ...
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97-2201.pdf
... of MHC Gene ...a gene transactivated by STAT1 a were also near normal early after IFN-g ...of MHC class II, H-2Ma, H-2Mb, and Ii are de- pendent on the class ...
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Association of CD99 short and long forms with MHC class I, MHC class II and tetraspanin CD81 and recruitment into immunological synapses
... CD99 is expressed as two distinct isoforms, a long 32 kDa form (type I) and a short 28 kDa form (type II) resulting from an alternative splicing process of the pro- duct of the encoding gene [22]. In the ...
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The systems biology of MHC class II antigen presentation
... sequences can be easily introduced into cells by lipid-based transfection methods. Libraries of siRNA are often designed in an arrayed format with every well of a 96- or 384-well plate containing siRNAs targeting a ...
97
Sex-dependent treatment of chronic EAE with partial MHC class II constructs
... partial MHC class II constructs have been described elsewhere [15, ...single-chain gene was cloned into the NcoI and XhoI restriction sites of the pET21d(+) vec- tor (Novagen) and transformed ...
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Cytotoxic T lymphocyte responses to Ras protein
... reduced class II MHC on their cell surface (365, ...Ki-ras gene, did not cause reduced cell surface class II expression ...of class II in murine cell lines ...of ...
217
Novel epitope based peptides for vaccine against SARS-CoV-2 virus: immunoinformatics with docking approach
... Results: A total of fourteen linear B-cell epitopes where GQSKRVDFC displayed the highest antigenicity-score and sixteen highly antigenic 100% conserved T-cell epitopes including the most potential vaccine candidates ...
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Counterregulatory effects of interferon gamma and endotoxin on expression of the human C4 genes
... decreases monocyte C4 expression and completely abrogates the effect of IFN-gamma on the expression of this gene. In contrast, LPS and IFN-gamma have a synergistic effect in upregulating expression of another ...
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Molecular aspects of primary immunodeficiencies: lessons from cytokine and other signaling pathways
... candidate gene approaches and by positional ...of gene-tar- geted mice preceded the identification of human mutations, whereas in other cases, the reverse was ...and gene therapy, has also moved at a ...
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Posttranscriptional Inhibition of Class I Major Histocompatibility Complex Presentation on Hepatocytes and Lymphoid Cells in Chronic Woodchuck Hepatitis Virus Infection
... of class I MHC complexes on hepatocytes in chronically infected hosts must have significant immunopathogenic conse- ...reduced class I antigen expression are considered to be inherently suscepti- ble ...
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Lipid-laden partially-activated plasmacytoid and CD4−CD8α+ dendritic cells accumulate in tissues in elderly mice
... CD4 − CD8α + DCs, and that lipid content in these DCs in- creased with age. For example, in young-derived mesLNs, pDCs contained the most lipid, followed by CD4 − CD8α + DCs, CD4 + CD8α − DCs and CD4 − CD8α − DCs; lipid ...
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A Novel Predictive Technique for the MHC Class II Peptide-Binding Interaction
... the MHC molecule and the bound peptide was analyzed using the anal program ...the MHC Class II binding interaction, it is necessary to provide some means of comparisons to the experi- mental ...
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Evolution of MHC Class II Eβ Diversity Within the Genus Peromyscus
... analyzed. MHC diversity and allelic polymorphism among a group Estimates of recombination, mutation, and selection: of closely related rodent species in the genus Peromys- Estimates of population recombination ( ...
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Footprints of antigen processing boost MHC class II natural ligand predictions
... processed MHC eluted ...current MHC class II binding prediction and/or in vitro binding assay methods, since researchers could use these tools to select which peptides to include in a T cell ...
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Aspects of the cell biology of antigen processing for MHC II
... are MHC Expression of MHC II and the second signal are both induced by bacterial cell wall components and inflammatory cytokines such as gamma-IFN and IL-1 (Weaver and Unanue, 1990; Janeway, ...an ...
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