MHC class II proteins
A Novel Bat Herpesvirus Encodes Homologues of Major Histocompatibility Complex Classes I and II, C-Type Lectin, and a Unique Family of Immune-Related Genes
... 93 proteins with identifiable homologues in tree shrew her- pesvirus (THV), human cytomegalovirus (HCMV), or rat cytomegalovirus (RCMV), most had highest sequence identities with THV ...(MHC)-related ...
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A Novel Predictive Technique for the MHC Class II Peptide-Binding Interaction
... (MHC) Class II mole- cules are specialized glycoproteins found on the surface of antigen- presenting cells ...the MHC Class II molecule and a foreign pep- tide fragment presented ...
6
Inhibition of HLA-DR Assembly, Transport, and Loading by Human Cytomegalovirus Glycoprotein US3: a Novel Mechanism for Evading Major Histocompatibility Complex Class II Antigen Presentation
... the MHC-I pathway, as well as at least one inhibitor of the class II pathway, we wondered if there might be other inhibitors of the MHC-II ...of class II proteins ...
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The systems biology of MHC class II antigen presentation
... While MHC-I binds peptides in a partially folded state stabilized by chaperones in the ER, this is probably different for MHC-II, as endosomes are not known to contribute to ...of ...
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Designing of interferon-gamma inducing MHC class-II binders
... or proteins is extremely valuable in the field for functional annotation of proteins/peptides ...None, ii) Koolman-Rohm and iii) Betts- ...Polar, ii) Hydrophobic and iii) ...
15
Presentation of intracellular antigen with MHC class II molecules
... Ag enters the cell by endocytosis, w here it becom es localized in endosom es w hich are intracellular vesicles form ing p a rt of the endocytic pathw ay. Endosom es so rt proteins, recycling som e such as the ...
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Association of CD99 short and long forms with MHC class I, MHC class II and tetraspanin CD81 and recruitment into immunological synapses
... including MHC and tetraspanin CD81, have been shown to translocate into the IS dur- ing T cell activation ...with MHC class II of APCs has been observed in which they function as cell surface ...
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Interaction of the proteins which regulate MHC class II-mediated antigen presentation by antigen presenting cells
... I-Ad class II molecules for ...I-Ad class II molecules, by catalyzing conformational change of the I-Ad in the acidic environment of the MIIC after the loss of a direct association with intact ...
171
Virus-Like Particles as Carriers for T-Cell Epitopes: Limited Inhibition of T-Cell Priming by Carrier-Specific Antibodies
... (MHC) class I pathway. In general, exogenous antigens reach the MHC class II pathway while only endogenous antigens efficiently fuel the MHC class I pathway (7, ...the ...
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The Major Histocompatibility Complex Class I Genes of Zebrafish.
... 2001), MHC molecules also play a central role in adaptive immunity through presenting antigens to T ...cells. MHC class I molecules present cytosolic antigens to CD8 + cytotoxic T cells while ...
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The interaction of HLA-DM with conventional MHC class II molecules
... s II e n c o d e d “ n o n - c l a s s i c a l ” heterodim eric molecule, form ed a very stable com plex with HLA- DM in Hela-transfectants and needed DM in order to leave the ER and be ta rg e te d to the en d o ...
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Blocking MHC class II on human endothelium mitigates acute rejection
... of class I and class II major histocompatibility complex (MHC) molecules expressed by graft cells (4, ...of MHC molecules, cross-react against nonself (graft) MHC molecules ...
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MHC class II-restricted T cell responses to flaviviruses
... Further, when the class II antigens from resting and activated B cells were incorporated in artificial planar membranes they showed a similar capacit'y to present ovalbumin peptides to s[r] ...
243
Susceptibility of amphibians to chytridiomycosis is associated with MHC class II conformation
... Further work is needed to assess the prevalence of the three pocket conformations in other Bd-resistant species. Also, our work suggests that the frequency of these conformations should increase in susceptible species as ...
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Varicella-Zoster Virus Productively Infects Mature Dendritic Cells and Alters Their Immune Function
... human MHC class I (clone Tu149; phycoerythrin [PE] conjugated), human MHC class II (clone TU36; PE conjugated), human CD3 (clone ...
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Tumor-specific CD4 T cells eradicate myeloma cells genetically deficient in MHC class II display
... Nucleofector II (Lonza, Basel, Switzerland) with subsequent selection using medium containing ...Nucleofector II (Lonza; Program U16), and GFP-positive cells were single-cell sorted 24 h later using a ...
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Novel epitope based peptides for vaccine against SARS-CoV-2 virus: immunoinformatics with docking approach
... 10 MHC class I binding T-cell peptides and 6 MHC class II binding T- cell peptides that are all conserved potential epitopes that might serve as potential peptide vaccine candidates for ...
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Lipid-laden partially-activated plasmacytoid and CD4−CD8α+ dendritic cells accumulate in tissues in elderly mice
... lipo- proteins reach circulation via mesenteric lymph and the thoracic duct; as such mesLNs may also be exposed to high concentrations of these lipoproteins, and of the lymph nodes examined, mesLNs showed more ...
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Molecular aspects of primary immunodeficiencies: lessons from cytokine and other signaling pathways
... (LAD II) is caused by deficient expression of sialyl Lewis X determinants, the neu- trophil ligands for E- and ...LAD II present with less severe infections than LAD I patients, along with developmental ...
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Evolution of MHC Class II Eβ Diversity Within the Genus Peromyscus
... the MHC has been slowed by an inability to assess the relative roles of mutation ...of class II ...the MHC. We investigated the evolution of MHC class II E sequence ...
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