MHC-I
Non-Invasive Monitoring of CNS MHC-I Molecules in Ischemic Stroke Mice
... With the development of bioinformatics and immunological studies on the mechanism of MHC-epitope interactions, some bioinformatics tools, including NetMHC 4.0 Server, EPIPOX and TepiTool, had been designed to ...
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Expression of m157, a Murine Cytomegalovirus-Encoded Putative Major Histocompatibility Class I (MHC-I)-Like Protein, Is Independent of Viral Regulation of Host MHC-I
... Infection with human cytomegalovirus can cause severe and fatal disease in neonates and immunocompromised individuals (9, 25). Although cytomegalovirus infection is species trophic, murine cytomegalovirus (MCMV) has ...
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The Missing Link in Epstein-Barr Virus Immune Evasion: the BDLF3 Gene Induces Ubiquitination and Downregulation of Major Histocompatibility Complex Class I (MHC-I) and MHC-II
... of MHC molecules at, and their internaliza- tion from, the cell surface involves ubiquitination of MHC mole- cules and a proteasome-dependent ...of MHC molecules for ubiquitination has been described ...
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Direct Binding of Human Immunodeficiency Virus Type 1 Nef to the Major Histocompatibility Complex Class I (MHC-I) Cytoplasmic Tail Disrupts MHC-I Trafficking
... affect MHC-I at two different cellular locations to achieve efficient downregulation and targeting of MHC-I to the TGN ...of MHC-I at the plasma membrane (14, ...redirecting ...
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ADP Ribosylation Factor 1 Activity Is Required To Recruit AP-1 to the Major Histocompatibility Complex Class I (MHC-I) Cytoplasmic Tail and Disrupt MHC-I Trafficking in HIV-1-Infected Primary T Cells
... class I (MHC-I), and evidence has been accumulating that this function of Nef is important in ...of MHC-I by stabilizing a protein-protein interaction between the clathrin adaptor ...
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Nef-Induced CD4 and Major Histocompatibility Complex Class I (MHC-I) Down-Regulation Are Governed by Distinct Determinants: N-Terminal Alpha Helix and Proline Repeat of Nef Selectively Regulate MHC-I Trafficking
... part of an SH3-binding motif in the Nef core domain (refer- ence 31 and this study), and a conserved a-helix near the N terminus of the protein (this study). The last two regions of Nef have been shown to participate in ...
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MHC-I promotes apoptosis of GABAergic interneurons in the spinal dorsal horn and contributes to cancer induced bone pain
... neuronal MHC-I expression renders neurons vulnerable to cytotoxic CD8 + T cells and finally lead to neurons apoptosis in a variety neurological ...whether MHC-I could induce the apoptosis of ...
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Involvement of human leukocyte antigen class I molecules in human immunodeficiency virus infection of CD4-positive cells.
... Questioning the exact roles of virus-associated MHC-I molecules and cell surface-expressed MHC-I molecules during the HIV life cycle became urgent, particularly in light of the debate su[r] ...
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DNMT1 regulates expression of MHC class I in post-mitotic neurons
... Complex I (MHC-I) molecules present cellularly derived peptides to the adaptive immune ...Generally MHC-I is not expressed on healthy post-mitotic neurons in the central nervous system, ...
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Equine Herpesvirus Type 1-Mediated Oncolysis of Human Glioblastoma Multiforme Cells
... human MHC-I, were blocked with antibody to MHC-I, indicating that human MHC-I acts as an EHV-1 entry receptor on glioma ...
5
Protective immunity against acute toxoplasmosis in BALB/c mice induced by a DNA vaccine encoding Toxoplasma gondii elongation factor 1 alpha
... T lymphocytes play an important role in host resistance to T. gondii infection [62]. CD3 + CD4 + CD8 − is the surface marker of T helper (Th) cells that can participate in the adaptive immune responses, while CD3 + CD8 + ...
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COVID-19 Vaccine Candidates by Identification of B and T Cell Multi-Epitopes Against SARS-COV-2
... Many studies identified drug and vaccine candidates successfully for various bacteria and virus using reverse vaccinology approach (Kumar 2011, 2015; Kumar and Ramanujam 2020; Omeershffudin and Kumar 2019). In this ...
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Differential Incorporation of CD45, CD80 (B7-1), CD86 (B7-2), and Major Histocompatibility Complex Class I and II Molecules into Human Immunodeficiency Virus Type 1 Virions and Microvesicles: Implications for Viral Pathogenesis and Immune Regulation
... incorporated MHC class I (MHC-I), MHC-II, CD80, or ...increased MHC-II expression on T- and B-cell lines, macrophages, and peripheral blood mononclear cells (PBMC) but did not ...
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Evolution of MHC class I genes in the European badger (Meles meles)
... (Meme-MHC I ∗ PS08N clustering with DLA-64 but with low bootstrap support ...class I genes than class II genes in mammals (Hughes and Nei 1989; Piontkivska and Nei 2003) and possibly reveals why ...
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THE ANALYTICAL STUDY OF ANTIGENICITY AND MHC BINDER OF THE CYTOCHROME C OXIDASE SUBUNIT I
... predicted MHC-I peptide binders of protein for 8mer_H2_Db alleles with the consensus sequence QNWNCCTI that yields the maximum score ...53.145, MHC-II I_Ag7 with the consensus sequence WYAHAFKYV that ...
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Simian immunodeficiency virus induces expression of class II major histocompatibility complex structures on infected target cells in vitro.
... Although MHC-I as well as MHC-II antigens are expressed in greater quantity on the surfaces of chronically SIV-infected cells than on uninfected cells, we were unable to demonstrate the [r] ...
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Antigen Expression Kinetics and Immune Responses of Mice Immunized with Noninfectious Simian-Human Immunodeficiency Virus DNA
... We undertook this study to document in vivo events after the inoculation of a DNA vaccine for the generation of im- mune responses. The kinetics of antigen production in skeletal muscle cells were similar to those ...
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The systems biology of MHC class II antigen presentation
... While MHC-I binds peptides in a partially folded state stabilized by chaperones in the ER, this is probably different for MHC-II, as endosomes are not known to contribute to ...of MHC-II ...
97
A non proteolytic role for ubiquitin in deadenylation by the RNA binding E3 ligase MEX 3C
... (UTR) of its target mRNA HLA-A2 (an MHC-I allotype) through its KH domains and together with its cargo mRNA shuttles from the nucleus to the cytosol 3,5 . This HLA-A2 mRNA substrate bound to MEX-3C cannot ...
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Original Article Comparative immunoprofiling of polymyositis and dermatomyositis muscles
... both MHC-I and MHC-II are cell surface molecules whose major biolo- gical function is to present exogenous and endogenous antigens to immune ...of MHC-I and MHC-II in PM and DM, ...
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