Microarray-based comparative genomic hybridization
Angelman Syndrome due to familial translocation: unexpected additional results characterized by Microarray-based Comparative Genomic Hybridization
... including Microarray-based Comparative Genomic Hybridization, which revealed additional unexpected results: a coincidental and smaller 15q deletion, asymptomatic duplications in ...
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Assessing karyotype precision by microarray-based comparative genomic hybridization in the myelodysplastic/myeloproliferative syndromes
... genome-wide microarray testing is a powerful technol- ogy for detecting recurring, submicroscopic alterations in genes that contribute to the pathogenesis of MDS ...chromosomal microarray testing will ...
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Original Article Scanning all chromosomal abnormalities with microarray-based comparative genomic hybridization in differential diagnosis of pediatric cancers
... the comparative genomic hybridization anal- ysis, the differences in the number of copies in the whole genome or in a region on the genome with a referenced genome were determined using NimbleGen CGH ...
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Comparative Genomics of Host-Specific Virulence in Pseudomonas syringae
... DNA microarray-based comparative genomic hybridization against an array containing 353 virulence-associated (VA) genes, including 53 type III secretion system effectors ...
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Comparative genomic hybridization on microarray (a-CGH) in constitutional and acquired mosaicism may detect as low as 8% abnormal cells
... the microarray- based comparative genomic hybridization (a-CGH) to investigate unbalanced chromosome anomalies, both constitutional and acquired, has largely changed and improved ...
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Application of Array Based Comparative Genomic Hybridization to Pediatric Neurologic Diseases
... situ hybridization (FISH), poly- merase chain reaction (PCR) and array techniques have been developed to increase early detection rates of microdeletion and ...parative genomic hybridization ...
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Unexpected structural complexity of supernumerary marker chromosomes characterized by microarray comparative genomic hybridization
... targeted microarray demonstrated gains of the pericentromeric regions of 1p, 4q, 7p, and 11q ...expected based on the results from ...targeted microarray that was used for array CGH, and the X ...
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Identification of small marker chromosomes using microarray comparative genomic hybridization and multicolor fluorescent in situ hybridization
... If the origin of the marker chromosome was not clari- fied by the above strategies, we then performed whole chromosome painting multicolor-FISH (M-FISH) and/or array CGH, based on the level of mosaicism, and the ...
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Discrepancy of QF-PCR, CMA and karyotyping on a de novo case of mosaic isodicentric Y chromosomes
... Chromosome microarray (CMA) analysis based on Comparative Genomic Hybridization (aCGH) platform was performed and identified a ...situ hybridization (FISH) revealed a mosaic cell ...
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Genetic analysis of products of conception using a HLPA/SNP-array strategy
... chromosomal microarray analysis (CMA) and next generation sequencing (NGS) enable us to identify submicroscopic imbalances on the whole genome with higher resolution [6, ...array-based comparative ...
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Investigation of copy number variations on chromosome 21 detected by comparative genomic hybridization (CGH) microarray in patients with congenital anomalies
... [41]. Based on the potential gene-dosage effect of GRIK1 and the pheno- types displayed by DECIPHER 257308 which involved excitability, the GRIK1 gene should be considered to be a strong candidate gene responsible ...
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Genomic profiling of rectal adenoma and carcinoma by array-based comparative genomic hybridization
... Agilent Genomic Workbench (Agilent Technologies, Santa Clara, CA) and MD-SeeGH ...(Agilent Genomic Workbench) was applied to identify common genomic ...as genomic gain, > ...
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Yield of comparative genomic hybridization microarray in pediatric neurology practice
... group based in Melbourne, Australia, have investigated the diagnostic yield of aCGH in a broad cohort of children seen in the pediatric neurology setting, similar to this ...CGH microarray platforms are ...
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Array-CGH diagnosis in ovarian failure: identification of new molecular actors for ovarian physiology
... CGH Genomic Labeling System (Invitrogen, Carlsbad, CA, ...After hybridization, the slides were counterstained with 4,6-diamino-2-phenyl-indol or DAPI (Qbiogene MP Bio- medicals, Santa Ana, CA, ...
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Characterization of Chromosomal Abnormalities in Cancer by Spectral Karyotyping
... situ hybridization technique (FISH) enabled detection of chromosomal microdeletions and structural abnormalities ...as comparative genomic hybridization (17) and spectral karyotyping (SKY) ...
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Microarray-based genomic profiling and in situ hybridization on fibrotic bone marrow biopsies for the identification of numerical chromosomal abnormalities in myelodysplastic syndrome
... of microarray-based genomic profiling com- pared to FISH and Chromogenic in situ hybridizations on bone marrow ...situ hybridization and microarray-based genomic pro- ...
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Transient multifocal genomic crisis creating chromothriptic and non-chromothriptic rearrangements in prezygotic testicular germ cells
... confined genomic chaos of 2q may result from atypical chromo- ...the genomic crisis in this case appears to have occurred during premeiotic ...multifocal genomic crisis in our case leading to chro- ...
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Chromosome copy number changes carry prognostic information independent of KIT/PDGFRA point mutations in gastrointestinal stromal tumors
... 12q. Genomic complexity (three or more aberrations per tumor), the presence of gains, deletions at 1p, and deletions at 22q were associated with a shorter disease- free survival in this subset of patients, with ...
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Molecular cytogenetic characterization of undifferentiated embryonal sarcoma of the liver: a case report and literature review
... array comparative genomic hybridization (aCGH), fluorescence in situ hybridization (FISH) findings, and a missense mutation of TP53 gene by DNA sequencing in a 19-year-old patient with ...
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Submicroscopic copy-number variations associated with 46,XY disorders of sex development
... array-based comparative genomic hybridization (aCGH), multiplex ligation-dependent probe amplification (MLPA), and next-generation sequencing (NGS), have enabled high-throughput analysis of ...
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