Micronucleus Assay
The Cytokinesis Block Micronucleus Assay on Peripheral Blood Lymphocytes as a Prospective Biological Test System to Estimate the Influence of Radon on the Human Organism: Recent Progress and Future Prospects
... cytokinesis-block micronucleus assay (CBMN) in peripheral blood lymphocytes is one of the most estab- lished in vivo cytogenetic assays in the field of genetic ...CBMN assay detects nuclear buds ...
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CYTOKINESIS-BLOCK MICRONUCLEUS ASSAY IN HUMAN GLIOMA CELLS EXPOSED TO RADIATION
... the micronucleus assay. Cytokinesis block used in the assay enables accurate evaluation of MN generation after exposure, since cells undergoing mitosis at the time of irradiation ...CBMN assay ...
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Evaluation of the novel liver micronucleus assay using formalin-fixed tissues
... The micronucleus assay using the liver, which is the main organ for drug metabolism, has been known to be important but not widely used because hepatocyte (HEP) proliferation in adult rats is slow and thus ...
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Micronucleus assay in urothelial cells of patients with abnormal colposcopy and histopathological correlation
... This is to certify that this dissertation work titled “ MICRONUCLEUS ASSAY IN UROTHELIAL CELLS OF PATIENTS WITH ABNORMAL COLPOSCOPY AND HISTOPATHOLOGICAL CORRELATION” of the candidate Dr.T.M.VINCY with ...
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Radioprotective effects of selenium and vitamin-E against 6MV X-rays in human blood lymphocytes by micronucleus assay
... Methods: Fifteen volunteers were divided into three groups include A, B and C. These groups were given se- lenium (800IU), vitamin-E (100mg) and selenium (400IU) + vitamin-E (50mg), respectively. Peripheral blood samples ...
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Micronucleus Assay in Urothelial Cells in Cancer Cervix
... This is to certify that this dissertation entitled “MICRONUCLEUS ASSAY IN UROTHELIAL CELLS IN CANCER CERVIX" is a bonafide record of original work done by Dr. S. SURESH KUMAR, under our guidance and ...
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Micronucleus assay and pro oxidant status of patients with known chromosomal aneuploidy
... higher Micronucleus level than ...of Micronucleus frequency (MN) than healthy counterparts[24] indicating that the frequency of Micronucleus cells could be used as a marker of aneuploidy ...of ...
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Evaluation of Micronucleus Assay in Oral Exfoliated Buccal Cells in Potentially Malignant Disorders and Oral Squamous Cell Carcinoma
... Materials and methods: A study sample of 45 subjects was divided into three groups: Group I had 15 healthy subjects as controls, group II had 15 cases of potentially malignant disord[r] ...
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... This study concludes that Pap is a better stain over MGG for the micronucleus assay screening of the buccal cells. The severity of the buccal changes which were associated with smokeless tobacco use was ...
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Mutagenicity Evaluation of an Azo Dye - Reactive Red Using the Ames Test and in Vitro Cytokinesis Block Micronucleus (CKB-MN) Assay
... Block micronucleus (CKBMN) assay in human ...vitro micronucleus assay in human peripheral blood lymphocytes at the doses tested and the experimental conditions ...
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Micronucleus as Potential Biomarker of Oral Carcinogenesis
... When the target tissue of interest is epithelial tissue, the exfoliated cell micronucleus assay has advantages over the more widely used micronucleus test in lymphocytes. While lymphocytes must be ...
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Evaluation Of Genetic Damage In Buccal Epithelial Cells Of Asbestos Industry Workers Using Micronuclues Assay
... Asbestos is a known carcinogen and its carcinogenic properties has been reported (Mossmar and Gee, 1989) epidemiological and clinical studies have shown asbestos fibres are associated with development of neoplasia, lung ...
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Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™)
... Scrutiny of nanoparticle penetration and cellular up- take was found vital to dose-response interpretation, with the uptake studying showing that: (1) 3D topical exposures did not penetrate the stratum corneum skin- ...
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Cryopreservation and genetic damage : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Science in Genetics at Massey University
... That Sister Chromatid Exchange, Micronucleus Assay and Fluorescence in situ Hybridisation can be performed on whole blood of radiation exposed veterans and non-exposed controls after a p[r] ...
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Prevention of DNA damage and anticarcinogenic activity of Activia in a preclinical model.
... The micronucleus assay is important to identify clastogenic and aneugenic agents and was carried out according to Hayashi et al. (1990) with the modifications suggested by Oliveira et al. (2009). Glass ...
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The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications
... biological assay, has been used in many fields, such as: eco-genotoxicity [30], toxi- cology [31], pharmacology [32], and nutrigenomics ...the micronucleus assay is an effective tool for detecting ...
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Anticarcinogenic and Chemopreventive effect of AndrographisPaniculata extract in Swiss albino mice
... the micronucleus assay CP has been used as a clastogen and anticlastogenic effect of ...of Micronucleus assay showed that single application of ...of micronucleus formation in PCE cell ...
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Cryopreservation and genetic damage : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Science in Genetics at Massey University
... In this study three cytogenetic tests: Sister Chromatid Exchange SCE, Micronucleus Assay MN and Fluorescence in situ Hybridisation FISH were conducted on whole blood samples from ten par[r] ...
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Micronucleus frequency in children exposed to biomass burning in the Brazilian Legal Amazon region: a control case study
... Children are more susceptible to the effects of expo- sure to air pollution, especially respiratory diseases in terms of harm to human health associated with exposure to biomass burning pollutants [20-23]. A study con- ...
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In vitro detection of in vitro secondary mechanisms of genotoxicity induced by engineered nanomaterials
... vitro micronucleus assay, in the first in- stance following exposure of 16HBE14o − to dSPION suspended in an immune cell (dTHP-1 macrophage) con- ditioned cell culture ...
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