microRNA-145
Regulatory Mechanism of MicroRNA 145 in the Pathogenesis of Acute Aortic Dissection
... Sixty samples of the ascending aorta in patients with AAD (28 type) and aortic valve disease (32 aortic valve replacement) were obtained during surgery. Aortic samples from donors for heart transplants were used as ...
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Original Article MicroRNA-145 suppresses cell migration and invasion by targeting paxillin in human colorectal cancer cells
... presumably adhesion turnover, by preventing the polyubiquitination of paxillin and its subse- quent degradation [33]. Given its roles in cell adhesion and migration, paxillin is thought to play an important role in tumor ...
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MicroRNA 145 regulates oncolytic herpes simplex virus 1 for selective killing of human non small cell lung cancer cells
... Micro-RNAs (miRNAs) are non-coding small RNAs bound to the 3′-untranslated region (3′-UTR) of targeted messenger RNAs and affect either messenger RNA cleavage or translational inhibition of genes at the ...
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MicroRNA-145 engineered bone marrow-derived mesenchymal stem cells alleviated erectile dysfunction in aged rats
... After 14 days of manipulation, penile specimens were immunostained and underwent Western blotting to in- vestigate the expression of SMC markers. As shown in Fig. 4a, the mRNA levels of α-SMA, desmin, and SM- MHC were ...
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Prognostic role of microRNA 145 in various human malignant neoplasms: a meta analysis of 18 related studies
... As a tumor suppressor, miR-145 has been reported to have downregulated expression in various cancer tissues, although the targets of miR-145 have not been defini- tively identified [8-11]. A number of ...
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Original Article MicroRNA-145 induces cell cycle arrest in G1 phase by directly targeting KLF5 in colon cancer
... Here, we predicted that KLF5, a member of the zinc finger family of proteins, may be one direct target gene negatively regulated by miR-145. To identify the bona fide target genes of a specific miRNA, solid ...
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<p>Function of microRNA-145 and mechanisms underlying its role in malignant tumor diagnosis and treatment</p>
... growth in MCF-7 and HCT-116 cells, it has no significant effect on cell growth in metastatic breast cancer cell lines. However, miR-145 significantly suppresses cell invasion in these cells. Using luciferase ...
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MicroRNA-145 downregulation associates with advanced tumor progression and poor prognosis in patients suffering osteosarcoma
... For the first time, the current data offer convincing evidence that the downregulation of miR-145 may be associated with tumor aggressiveness and tumor metastasis of osteosarcoma, and that this miRNA may be an ...
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Original Article Investigation of microRNA-145 as a serum diagnostic and prognostic biomarker for gastric cancer: a Chinese cohort-based study
... an level) and low serum miR-145 expression group (n=56; serum miR-145 level ≤ median level). The correlations between clinicopatho- logical variables and serum miR-145 levels of 114 GC patients were ...
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MicroRNA-145 inhibits the activation of the mTOR signaling pathway to suppress the proliferation and invasion of invasive pituitary adenoma cells by targeting AKT3 in vivo and in vitro
... Methods: A total of 71 cases of IPA tissues and 66 cases of non-IPA tissues were obtained in this study. In vitro, the IPA cells were assigned into blank control, empty plasmid, miR-145 mimic, miR-145 ...
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MicroRNA-145-5p inhibits gastric cancer invasiveness through targeting N-cadherin and ZEB2 to suppress epithelial–mesenchymal transition
... screening indicates that ZEB2 is the candidate target gene of miR-145-5p in relation to E-cadherin–induced GC cell invasion and migration. In our study, qRT-PCR and Western blot analyses confirmed that ZEB2 ...
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<p>MicroRNA-145 inhibits growth of laryngeal squamous cell carcinoma by targeting the PI3K/Akt signaling pathway</p>
... Tumor development is a complex process involving multiple factors and stages, typically arising from the accumulation of multiple gene mutations. As a result, the etiology and biological mechanisms underlying the prolif- ...
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Dual-strand tumor-suppressor microRNA-145 miR-145-5p and miR-145-3p ) coordinately targeted MTDH in lung squamous cell carcinoma
... Patients with lung adenocarcinoma may benefit from recently developed molecular targeted therapies. However, analogous advanced treatments are not available for patients with lung squamous cell carcinoma (lung SCC). The ...
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Human Papillomaviruses Modulate MicroRNA 145 Expression To Directly Control Genome Amplification
... FIG 1 Levels of miR-145 are repressed in HPV-31-positive organotypic rafts. (A) qPCR analysis of miR-145 levels in 13-day-old organotypic raft cultures of matched normal keratinocytes (viv) and HPV-positive ...
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<p>MicroRNA 145 enhances chemosensitivity of glioblastoma stem cells to demethoxycurcumin</p>
... promotes cell proliferation and tumor formation by regulating the transcriptional regulation of target genes. Recent studies showed that high expression of the SOX2 gene could be found in many tumors, including breast ...
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Intravesical administration of exogenous microRNA-145 as a therapy for mouse orthotopic human bladder cancer xenograft
... We conducted intravesical instillation of liposome- encapsulated miR-145 after emptying the residual urine from the bladder. By doing so, we avoided the effects of RNase and immunological surveillance systems ...
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<p>MicroRNA-145 Inhibits Cell Migration and Invasion in Colorectal Cancer by Targeting TWIST</p>
... through knockdown of mRNA translation, and also play oncogenic or tumor-suppressive roles according to the regulatory targets. 4 Recent reports have indicated that miRNAs play important roles in the occurrence and devel- ...
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Original Article Expression of microRNA (miR)-145 and miR-34a in different cervical lesion tissues of Uygur and Han females in Xinjiang, China
... In this study, the expression of miR-145 and miR-34a in different cervical lesion tissues was detected with quantitative real-time PCR. Our results showed that, compared with normal tis- sues, the expression ...
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Original Article Involvement of miR-145 in the pathogenesis of osteoarthritis by mediating the expression of osteoprotegerin
... The main reagents used in the study include: total RNA extraction kit EasyPure miRNA Kit, TransScript Green miRNA Two-Step qRT-PCR SuperMix (Beijing TransGen Biotech Corpo- ration, China, ER601-01, AQ202-01), FBS (fetal ...
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miR-145 supports cancer cell survival and shows association with DDR genes, methylation pattern, and epithelial to mesenchymal transition
... and death (apoptotic) pathway was analysed in tumour samples studied earlier [40] and under in vitro miR-145 regulation in the present study. No significant change in expression as well as methylation pattern of ...
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