microRNA-150
MicroRNA-150 enhances radiosensitivity by inhibiting the AKT pathway in NK/T cell lymphoma
... [10–12]. MicroRNA-150 (miR-150) has been va- lidated as an oncogene or tumor suppressor in several human malignancies [13, ...miR- 150 in NKTL therapeutic effects remain ...
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Prognostic role of microRNA-150 in various carcinomas: a meta-analysis
... We carefully searched the online PubMed and EMBASE databases until August 31, 2015, to identify relevant studies. For literature retrieval, combinations of the keywords, such as microRNA-150, ...
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Constitutive expression of microRNA 150 in mammary epithelium suppresses secretory activation and impairs de novo lipogenesis
... Global mRNA profiling identified significant gene expression changes due to constitutive expression of miR-150 in MECs (analyzed data in Table S5). In agreement with the bioinformatic predictions shown in Fig. 2C, ...
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Opposite Prognostic Significance of Cellular and Serum Circulating MicroRNA-150 in Patients with Chronic Lymphocytic Leukemia
... results). MicroRNA-16 (normalized to the exogenous control) was not used as a normalizer in this experiment because miR-16 itself is influenced by the centrifu- ...
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<em>MicroRNA-150</em> suppresses triple-negative breast cancer metastasis through targeting HMGA2
... prediction using both TargetScan and miRWalk2.0 soft- ware (Table S3). Among these mRNAs, the 10 most down-regulated ones were further analyzed by qRT-PCR, and the result shows that only five out of 10 mRNAs are down- ...
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Original Article Increased expression of microRNA-150 is associated with poor prognosis in non-small cell lung cancer
... Abstract: Objectives: The aim was to evaluate the clinical significance and prognostic value of tissue miR-150 ex- pression in non-small cell lung cancer (NSCLC) patients. Materials and methods: Quantitative ...
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Wnt/β-catenin pathway transactivates microRNA-150 that promotes EMT of colorectal cancer cells by suppressing CREB signaling
... The above results prompted us to determine whether the downregulation of CREB signaling mediated the effects of miR-150 overexpression: EMT and the subsequent increased migration of CRC cells. As expected, ...
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Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration
... We performed an a priori power calculation with G*Power 3.1 (54) to determine the appropriate sample size for our human studies. To detect a significant difference between AMD patients and control subjects (allocation ...
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microRNA-150: a promising novel biomarker for hepatitis B virus-related hepatocellular carcinoma
... TaqMan MicroRNA Assay Kits (Applied Biosystems, Foster City, ...TaqMan MicroRNA Reverse Transcription kit (Applied Biosys- tems, Foster City, ...TaqMan MicroRNA assay protocol, real-time PCR was ...
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Reversal of microRNA 150 silencing disadvantages crizotinib resistant NPM ALK(+) cell growth
... miR- 150 in these NK/T cell lymphoma cells reduces cell proliferation, suggesting that miR-150 functions as a tumor suppressor in these cells ...miR- 150 is downregulated in various NPM-ALK(+) ...
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Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663
... granulocytic differentiation. Both miR-107 and miR-223 are postulated to downregulate their target gene NFI-A, and mediate a regulatory loop during cell differentiation [22]. This data suggests miRNAs can function as ...
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Identifying MicroRNA Precursors Using Linear Dimensionality Reduction With Explicit Feature Mapping
... The authors obtained a total number of 2,241 pre-microRNAs from miRBase 8.2. They used 200 human pre-microRNAs and 400 randomly selected pseudo hairpins for training and finding parameters of miPred and called it TR-H. ...
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Prediction and Analysis of SARS-CoV-2-Targeting microRNA in Human Lung Epithelium
... that microRNA can mediate an intracellular defence mechanism against some RNA ...identify microRNA with predicted binding sites in the SARS-CoV- 2 genome, compare these to their microRNA expression ...
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Characterization and potential role of microRNA in the Chinese dominant malaria mosquito Anopheles sinensis (Diptera: Culicidae) throughout four different life stages
... Results: In total, 164 miRNAs were obtained out of 107.46 million raw sequencing reads. 99 of them identified as known miRNAs, and the remaining 65 miRNAs were considered as novel. By analyzing the read counts of miRNAs ...
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MicroRNA 889 Inhibits Autophagy To Maintain Mycobacterial Survival in Patients with Latent Tuberculosis Infection by Targeting TWEAK
... FIG 1 Increased microRNA-889 (miR-889) levels in patients with latent tuberculosis infection (LTBI). (A) Differentially expressed miRNAs in peripheral blood mononuclear cells (PBMCs) from rheumatoid arthritis (RA) ...
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Differences in microRNA expression between melanoma and healthy adjacent skin
... KEGG pathway analysis based on microRNA signature was performed with DIANA-mirPath v.3.0. MicroRNA targets were predicted with the use DIANA-microT-CDS computational tool. The threshold (P ≤ 0.05) and false ...
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The Intestinal Microbiota Interferes with the microRNA Response upon Oral Listeria Infection
... ABSTRACT The intestinal tract is the largest reservoir of microbes in the human body. The intestinal microbiota is thought to be able to modulate alterations of the gut induced by enteropathogens, thereby maintaining ...
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Early MicroRNA Expression Profile as a Prognostic Biomarker for the Development of Pelvic Inflammatory Disease in a Mouse Model of Chlamydial Genital Infection
... of microRNA (miRNA) sequencing and quantitative real-time PCR (qRT-PCR) analysis of 134 inflammation-related miRNAs was performed 24 h postinfection to determine if the chemokine/cytokine responses would also be ...
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Noncanonical MicroRNA (miRNA) Biogenesis Gives Rise to Retroviral Mimics of Lymphoproliferative and Immunosuppressive Host miRNAs
... Noncanonical MicroRNA (miRNA) Biogenesis Gives Rise to Retroviral Mimics of Lymphoproliferative and Immunosuppressive Host miRNAs Noncanonical MicroRNA (miRNA) Biogenesis Gives Rise to Retroviral Mimi[.] ...
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Original Article microRNA profiling in the hippocampus of isoflurane-anesthetized mice
... the microRNA profil- ing in the hippocampus of isoflurane-anesthetized mice with microRNA microarray profiling and real-time quantita- tive PCR methods, and the molecular signaling pathway enrichment ...
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