microRNA biogenesis
Dysregulation of microRNA biogenesis in cancer: the impact of mutant p53 on Drosha complex activity
... miRNA biogenesis pathway, such as genomic mutation or aberrant expression/localization of enzymes and cofactors responsible of miRNA ...miRNA biogenesis machinery impact on the establishment and development ...
9
Review, Hypothesis The Meaning of the Microprocessor: Accounting for Evolution of Structural-Functional Novelty in the Canonical microRNA Biogenesis Pathway.
... It is standard to identify and compare predicted protein sequence of the Drosha and Pasha genes subsidiary to detection and identification of novel microRNAs in newly sequenced taxa or review of previous deep sequencing ...
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In vivo Monitoring of microRNA Biogenesis Using Reporter Gene Imaging
... specific microRNA promoter can be used for monitoring the pri-miRNA expression during microRNA ...of microRNA is controlled by its own promoter [6]. To constitute a microRNA promot- ...
8
Adenovirus VA1 Noncoding RNA Can Inhibit Small Interfering RNA and MicroRNA Biogenesis
... Physiological levels of adenovirus VA1 RNA can inhibit miRNA biogenesis and function. Zeng et al. have previously described (41) the indicator construct pCMV-Luc-miR-30(P), containing the firefly luciferase (Luc) ...
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Impact of polymorphisms in microRNA biogenesis genes on colon cancer risk and microRNA expression levels: a population-based, case-control study
... miRNA biogenesis, as well as SNPs within bio- genesis genes that alter cancer risk, by searching PubMed and standard search engines for peer-reviewed articles containing keywords “miRNA” and “biogenesis”, ...
14
Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex
... miRNA biogenesis requires a series of sequential enzy- matic processing reactions, and key among these is DGCR8 (DiGeorge syndrome critical region gene 8), an RNA-binding protein that partners with the RNase III ...
10
MicroRNA Biogenesis and Hedgehog-Patched Signaling Cooperate to Regulate an Important Developmental Transition in Granule Cell Development
... A bistable phenotype was induced in Atoh1-Cre;Ptch1flox/ flox;Dicer1flox/flox mice, which strongly suggests that miRNA biogenesis and Hedgehog-Patched signaling together regu- late an important developmental ...
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Trans splicing of the C elegans let 7 primary transcript developmentally regulates let 7 microRNA biogenesis and let 7 family microRNA activity
... Trans-splicing is the act of joining two separate RNAs. In C. elegans, ∼ 70% of all transcripts (including mRNAs and microRNA primary transcripts) are trans-spliced with an SL RNA. The outcomes of trans-splicing ...
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A novel p70 S6 kinase-microRNA biogenesis axis mediates multicellular spheroid formation in ovarian cancer progression
... Furthermore, p70S6K overexpression in breast, colon, liver, and ovarian tumors are found to be related to aggressive malignant phenotypes [11, 42–44], suggesting that the role of p70S6K [r] ...
14
MicroRNA biogenesis and regulation of bone remodeling
... While the mechanisms regulating miRNA biogenesis have been well studied, the regulation of miRNA stability, particularly in vertebrates, is not well understood. It is known that mature miRNA abundance is sensitive ...
11
Regulation of MicroRNA Biogenesis: A miRiad of mechanisms
... miRNA biogenesis has increased dramatically since the discovery of miRNA, little is known about the mecha- nisms which control degradation and turnover of miR- ...miRNA biogenesis, the degradation of ...
22
The regulation of let-7 microRNA biogenesis in early embryogenesis
... knockout mice, coincidentally, are also upregulated by the DNA damaging agent Doxorubicin (Dox). As Dox strongly stimulates p53 activity, leading to induction of p53 responsive genes, it was perhaps not surprising that ...
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MicroRNA biogenesis and their functions in regulating stem cell potency and differentiation
... potency. MicroRNA analysis defined that embryonic stem cells (ESCs) and iPSCs have a distinct miRNA expression pattern as compared to the differentiated somatic cells ...
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MicroRNA Biogenesis is enhanced by Liposome- Encapsulated Pin1 Inhibitor in Hepatocellular Carcinoma
... Considering that XPO5 is an indispensable nucleus-to-cytoplasm transport vehicle for pre- miRNAs, we subsequently investigated whether API-LP could affect the biogenesis of mature miRNAs. Based on the abundance ...
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In Depth Analysis of the Interaction of HIV 1 with Cellular microRNA Biogenesis and Effector Mechanisms
... ABSTRACT The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in ...
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MicroRNA Deregulations in Head and Neck Squamous Cell Carcinomas
... Two microRNA biogenesis pathways have been described (Figure ...the microRNA genes are intergenic and utilize a canonical microRNA biogenesis pathway for their ...mature microRNA ...
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Role of the Trypanosoma brucei HEN1 Family Methyltransferase in Small Interfering RNA Modification
... and comparative modeling of HEN1, a methyltransferase involved in plant microRNA biogenesis. Unique 2 = -O-methylation by Hen1 in eukaryotic RNA interference and bacterial RNA repair. Vi[r] ...
10
Species Specificity in Ribosome Biogenesis: a Nonconserved Phosphoprotein Is Required for Formation of the Large Ribosomal Subunit in Trypanosoma brucei
... Ribosome biogenesis is a highly conserved process, although differences in rRNA processing are evident in many ...in biogenesis of the 60S subunit, with concurrent defects in processing of the large-subunit ...
6
Noncanonical MicroRNA (miRNA) Biogenesis Gives Rise to Retroviral Mimics of Lymphoproliferative and Immunosuppressive Host miRNAs
... We first confirmed that these SFV miRNAs are active in RISC (Fig. 4B). As expected, luciferase reporters bearing perfectly com- plementary sequences in their 3= UTRs were specifically and ro- bustly downregulated when ...
9
The role of Pex11-beta in peroxisome biogenesis, intracellular relationship to reactive oxygen species levels and redox-sensitive cell signaling
... Pex11 proteins were first identified in yeast as peroxisomal membrane proteins that could increase peroxisome number when overexpressed and significantly reduce peroxisome number when interrupted (Karnati and ...
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