MicroRNA expression and function
Regulation of microRNA expression and function by nuclear receptor signaling
... miRNA expression via three means: direct binding to the promoter regions of miRNAs, indirect regulation of miRNA expression through NR tar- get genes, and involvement in regulation of miRNA bio- genesis ...
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MicroRNA expression and function during porcine oocyte maturation and early embryonic development
... Abstract Seasonal infertility related to elevated temperatures has a detrimental impact on the reproductive efficiency of sows throughout the United States. Heat stress prior to ovulation, at the time of breeding, has ...
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microRNA expression and function in Embryonic Stem Cells: miR-100, miR-137 and miR-34a are required for ESC differentiation
... gene expression (Pasini, Bracken et ...premature expression of differentiation ...gene expression in a flexible manner, which can be reversed later by gene-specific and lineage- specific signals ...
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Impact of gastro-oesophageal reflux on microRNA expression, location and function
... miRNA expression is altered in the oesophageal squamous mucosa from individuals with gastro-oesophageal reflux and ulcerative ...these expression changes might influence proliferation and apoptosis and ...
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MicroRNA expression in human endometrial adenocarcinoma
... family using anti-miRs resulted in reduction of cell prolif- eration and enhanced the cytotoxic effect in endometrial cancer HEC-1A and Ishikawa cell lines [29]. One of the miRNAs that is differentially expressed in FIGO ...
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Comprehensive Analysis of Rhesus Lymphocryptovirus MicroRNA Expression
... Our study sheds light on the functional conservation of EBV and rLCV miRNAs. Since miRNAs base pair with target mRNAs in an imperfect manner, it is extremely challenging to accurately predict and validate target mRNAs. ...
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Epigenetic regulation of microRNA expression in colorectal cancer
... precise function of hsa-miR-9, hsa-miR-129, and hsa-miR-137 have not been characterized although abnormal expression has been described in tumor ...of expression in tumour tissue was .... ...
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Principles of microRNA Regulation Revealed Through Modeling microRNA Expression Quantitative Trait Loci
... The integrative analysis presented here provides new in- sights into patterns of cis-miRNA eQTLs which affect different steps of miRNA biogenesis. Several notable results emerge from our analysis. We find that both SNPs ...
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MicroRNA function and dysregulation in bone tumors: the evidence to date
... osteosarcoma and Ewing’s sarcoma. In relation to other types of primary bone tumors, there is a paucity of information regarding the role of miRNAs. Chondrosarcoma is the second most common primary bone malignancy ...
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MicroRNA-21 Exhibits Antiangiogenic Function by Targeting RhoB Expression in Endothelial Cells.
... RhoB expression in endothelial cells In order to identify putative target genes regulated by miR-21 and involved in the control of angiogenesis, we evaluated targets computationally predicted by publicly available ...
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microPrimer: the biogenesis and function of microRNA
... gene expression that control a broad range of physiological and developmental processes in plants and ...miRNA expression and maturation remains largely unknown, but many laboratories have begun to map ...
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Original Article Expression and function of microRNA-188-5p in activated rheumatoid arthritis synovial fibroblasts
... miR-188-5p expression levels compared to control cells. Re-expression of miR- 188-5p in RASF by transient transfection significantly inhibited cell ...or expression of repellent factors, which have ...
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Evolutionarily Conserved Function of a Viral MicroRNA
... the expression of reporters containing 150 nu- cleotides of complementary early gene transcripts and that our antisense inhibitors blocked JCV miRNA-mediated mRNA ...
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Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function
... miRNA expression levels in a variety of cell lines and their respective derived exosomes, and found that a subset of miRNAs ...the expression levels of let-7 miRNA family mem- bers in exosomes derived from ...
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Expression Analysis of MicroRNA-196a in Esophageal Cancer
... oncogenic function of miR-196 in cancers, few reports have indicated that the miR-196 family can act as tumor suppressors in some cancers, such as melanoma and breast cancer ...
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MicroRNA gene expression in the zebra finch brain
... to function as post-transcriptional regulators of gene expression, altering either the stability (amount) or functional readout (translation) of specific target ...and function, we used a new zebra ...
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Technical Note: Analysis of microrna function using mircury LNA TM microrna Inhibitors
... 3. MicroRNA reporter assays If suitable antibodies are not available, we instead recommend using a microRNA reporter ...studied microRNA has been introduced into the 3’-UTR of the ...the ...
7
MicroRNA-7a regulates pancreatic beta cell function
... Discussion Understanding the basic mechanism regulating the secretory response of pancreatic β cells to glucose remains a fundamental research topic for the elaboration of novel therapeutic avenues enhancing insulin ...
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Discovery and Application of Small Molecule Regulators of MicroRNA Function.
... the expression of certain miRNAs have been linked to a wide range of human diseases, including cancer and viral infections, identifying miRNAs as potential targets for drug ...the function of individual ...
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Identification of the microRNA networks contributing to macrophage differentiation and function
... miRNA expression and associated alterations in expression with putative mRNA targets that are critical during differentiation of ...with expression patterns that were differentially regulated 5-fold ...
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