Microsatellite instability
MRI Downstaging, Pathological Response and Microsatellite Instability Status in Patient’s with Signet Ring Cell Carcinoma Rectum undergoing Preoperative Long Course Chemo Irradiation
... AND MICROSATELLITE INSTABILITY STATUS IN PATIENT’S WITH SIGNET RING CELL CARCINOMA RECTUM UNDERGOING PREOPERATIVE LONG COURSE CHEMO IRRADIATION’ is a bonafide work done by ...
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H. pylori infection is related to mitochondrial microsatellite instability in gastric carcinogenesis
... Genetic instability plays a key role in neoplastic trans- formation and progression [17, ...etic instability may be classified into two different forms, in which hypermutability occurs by means of either ...
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Microsatellite instability: a review of what the oncologist should know
... the microsatellite loci detected in tumor tissues with normal ...as microsatellite markers to determine the status of MSI ...The instability of one site is called low microsatellite ...
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Spontaneous regression of transverse colon cancer with high frequency microsatellite instability: a case report and literature review
... 13. Jung J, Kang Y, Lee YJ, Kim E, Ahn B, Lee E, et al. Comparison of the mismatch repair system between primary and metastatic colorectal cancers using immunohistochemistry. J Pathol Transl Med. 2017;51(2):129 – 36. 14. ...
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Clinical Implications of Microsatellite Instability in T1 Colorectal Cancer
... High-frequency microsatellite instability (MSI-H) is likely to decrease the possibility of metastasis to either regional lymph nodes or distant organs in colorectal ...Five microsatellite markers, ...
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Original Article Absence of microsatellite instability in mucinous carcino- mas of the breast
... Subsets of colorectal [24], gastric [31], pancre- atic [31], ovarian [32] and endometrial tumours [22,31,33], and particularly those occurring in the hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome ...
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Microsatellite instability as prognostic marker in bladder tumors: a clinical significance
... high grade recur early and progress to invasive bladder cancer very soon. This behavior of same stage of the tumor but with varied grades is attributed to genetic alterations. Bladder cancer manifesting from superficial ...
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No Change in Frequency of Microsatellite Instability in Colorectal Cancers over a Period of 15 or More Years
... Microsatellite instability (MSI) is a molecular change resulting from inactiva- tion of DNA mismatch repair systems, occurring with a reported incidence between 15% - 20% of all sporadic colorectal ...of ...
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Microsatellite instability at a tetranucleotide repeat in type I endometrial carcinoma
... 2. Microsatellite instability at mono- or dinucleotide repeat markers was noted in eight of 39 tumors ...1) Microsatellite instability at tetranucle- otide repeat markers was observed in 15 of ...
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<p>Microsatellite Instability-Related <em>ACVR2A</em> Mutations Partially Account for Decreased Lymph Node Metastasis in MSI-H Gastric Cancers</p>
... Tumour metastasis is a very complex process involving both the intrinsic properties of tumour cells and the host response. 3 Traditional thought holds that the more gene mutations accumulate in cancer cells, the more ...
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Clinical Significance of Microsatellite Instability in Sporadic Epithelial Ovarian Tumors
... of microsatellite instability (MSI) in sporadic ovarian tumors using 5 standard and 9 new MSI markers to determine the clinical significance of MSI in sporadic epithelial ovarian ...
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Chemotherapy induced microsatellite instability and loss of heterozygosity in chromosomes 2, 5, 10, and 17 in solid tumor patients
... In reviewing the incidence of MSI and LOH in differ- ent solid tumors (Table 4), we observed that gastric, lung, ovarian, nasopharyngeal, pancreatic, squamous cell carcinoma, and prostate cancers (which together form 78% ...
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The immunogenicity of colorectal cancers with high degree microsatellite instability
... high-degree microsatellite instability, that gener- ate large numbers of abnormal proteins with consequent misfolding, might excite a heat shock protein ...
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Subtyping of microsatellite instability-high colorectal cancer
... tem, microsatellite instability-high (MSI-H) samples be- long to the CMS1 subtype and are characterized by hypermutation and CpG island methylator phenotype ...
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Is microsatellite instability high really a favorable prognostic factor for advanced colorectal cancer? A meta analysis
... “microsatellite instability,” “advanced stage,” and ...(((((Microsatellite Instability) OR Microsatellite Repeats) OR MSI) OR Mismatch repair) OR dMMR)) AND (((((((Neoplasm Metastasis) ...
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Microsatellite instability in Marek’s Disease Virus infected primary chicken embryo fibroblasts
... [6]. Microsatellite sequences are stably inherited with high accuracy mak- ing them excellent genetic ...of microsatellite sequences is unique to each individual and distinct among ...identical ...
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Original Article The relation of microsatellite instability to expression of hTERT in human gastric carcinoma
... 5 microsatellite loci in gastric carcinoma (MSI, microsatellite instability; MSS, microsatellite stability; N, paraneoplastic normal tissue; T, gastric ...
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Mutational profiling of colorectal cancers with microsatellite instability
... Microsatellite instability (MSI) is caused by defective mismatch repair in 15–20% of colorectal cancers (CRCs). Higher mutation loads in tumors with mismatch repair deficiency can predict response to ...
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Prognostic value of the combination of microsatellite instability and <em>BRAF</em> mutation in colorectal cancer
... OR microsatellite instability OR MSI”, “B-type Raf kinase OR BRAF”, and “prognosis OR survival OR overall survival OR recurrence-free survival OR RFS OR progression-free survival OR ...
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Mismatch repair deficiency/microsatellite instability-high as a predictor for anti-PD-1/PD-L1 immunotherapy efficacy
... The inactivation of MMR genes and MMR protein dysfunction may be the results of germline mutations or spontaneous hypermutation alterations, which may in- duce microsatellite instability (MSI). More than ...
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