Microsatellite Instability (MSI)
Microsatellite instability: a review of what the oncologist should know
... the microsatellite loci detected in tumor tissues with normal ...as microsatellite markers to determine the status of MSI ...The instability of one site is called low microsatellite ...
13
Spontaneous regression of transverse colon cancer with high frequency microsatellite instability: a case report and literature review
... There are two predominant forms of genomic instabil- ity characterized by CRC: chromosome instability (CIN) and microsatellite instability (MSI). The MSI-H CRCs account for approximately 15% of all ...
6
The immunogenicity of colorectal cancers with high degree microsatellite instability
... node positive cancers, and the link to improved survival has now been confirmed in a systematic review [34]. One explanation offered for the improved survival of MSI- H colorectal cancer patients has been that these ...
9
No Change in Frequency of Microsatellite Instability in Colorectal Cancers over a Period of 15 or More Years
... Several limitations should be noted. Prospective accrual for the later cases was poor, reflecting the general difficulty of patient accrual to clinical studies. The early group patients were all Stage 3, while the later ...
7
Clinical Significance of Microsatellite Instability in Sporadic Epithelial Ovarian Tumors
... The lack of MSI in this study could possibly be due to the small number of samples. In addition, the variation in the apparent MSI frequency might have been due to the choice of microsatellites an- alyzed, analytical ...
7
Clinical Implications of Microsatellite Instability in T1 Colorectal Cancer
... High-frequency microsatellite instability (MSI-H) is likely to decrease the possibility of metastasis to either regional lymph nodes or distant organs in colorectal ...Five microsatellite markers, ...
7
Original Article Absence of microsatellite instability in mucinous carcino- mas of the breast
... Subsets of colorectal [24], gastric [31], pancre- atic [31], ovarian [32] and endometrial tumours [22,31,33], and particularly those occurring in the hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome ...
16
H. pylori infection is related to mitochondrial microsatellite instability in gastric carcinogenesis
... Genetic instability plays a key role in neoplastic trans- formation and progression [17, ...etic instability may be classified into two different forms, in which hypermutability occurs by means of either ...
8
Microsatellite instability at a tetranucleotide repeat in type I endometrial carcinoma
... 2. Microsatellite instability at mono- or dinucleotide repeat markers was noted in eight of 39 tumors ...1) Microsatellite instability at tetranucle- otide repeat markers was observed in 15 of ...
8
<p>Microsatellite Instability-Related <em>ACVR2A</em> Mutations Partially Account for Decreased Lymph Node Metastasis in MSI-H Gastric Cancers</p>
... Tumour metastasis is a very complex process involving both the intrinsic properties of tumour cells and the host response. 3 Traditional thought holds that the more gene mutations accumulate in cancer cells, the more ...
13
Microsatellite instability as prognostic marker in bladder tumors: a clinical significance
... high grade recur early and progress to invasive bladder cancer very soon. This behavior of same stage of the tumor but with varied grades is attributed to genetic alterations. Bladder cancer manifesting from superficial ...
7
Chemotherapy induced microsatellite instability and loss of heterozygosity in chromosomes 2, 5, 10, and 17 in solid tumor patients
... [20,21]. Microsatellite instability (MSI) and loss of heterozygosity (LOH) are frequently described abnormalities known to be some of the early steps in the tumorigenesis pathway [22-24], and correction of ...
9
Original Article The relation of microsatellite instability to expression of hTERT in human gastric carcinoma
... Abstract: Objective: To investigate the role of microsatellite instability (MSI) in the pathogenesis of gastric carcinoma and its relationship with the expression of hTERT gene. Methods: 75 cases of gastric ...
7
Microsatellite instability in Marek’s Disease Virus infected primary chicken embryo fibroblasts
... [6]. Microsatellite sequences are stably inherited with high accuracy mak- ing them excellent genetic ...of microsatellite sequences is unique to each individual and distinct among ...identical ...
5
Mismatch repair deficiency/microsatellite instability-high as a predictor for anti-PD-1/PD-L1 immunotherapy efficacy
... The inactivation of MMR genes and MMR protein dysfunction may be the results of germline mutations or spontaneous hypermutation alterations, which may in- duce microsatellite instability (MSI). More than ...
14
Prognostic value of the combination of microsatellite instability and <em>BRAF</em> mutation in colorectal cancer
... OR microsatellite instability OR MSI”, “B-type Raf kinase OR BRAF”, and “prognosis OR survival OR overall survival OR recurrence-free survival OR RFS OR progression-free survival OR ...
19
Is microsatellite instability high really a favorable prognostic factor for advanced colorectal cancer? A meta analysis
... Unlike microsatellite-stable (MSS) CRCs, MSI-H not only had a much more active immune microenvironment with greater tumor-infiltrating lymphocytes (TIL), but also showed cancer-specific upregulation of inhibitory ...
13
Mutational profiling of colorectal cancers with microsatellite instability
... Microsatellite instability (MSI) is caused by defective mismatch repair in 15–20% of colorectal cancers (CRCs). Higher mutation loads in tumors with mismatch repair deficiency can predict response to ...
11
Subtyping of microsatellite instability-high colorectal cancer
... with microsatellite instability low (MSI-L) or microsatellite stable (MSS) CRC ...to microsatellite instabil- ity in predicting patients ’ disease-specific recurrence ...
10
MRI Downstaging, Pathological Response and Microsatellite Instability Status in Patient’s with Signet Ring Cell Carcinoma Rectum undergoing Preoperative Long Course Chemo Irradiation
... AND MICROSATELLITE INSTABILITY STATUS IN PATIENT’S WITH SIGNET RING CELL CARCINOMA RECTUM UNDERGOING PREOPERATIVE LONG COURSE CHEMO IRRADIATION’ is a bonafide work done by ...
104