Microsomal Triglyceride-transfer Protein
Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue specific knockout mice
... Received for publication February 17, 1999, and accepted in revised form March 25, 1999. A deficiency in microsomal triglyceride transfer protein (MTP) causes the human lipoprotein deficien- ...
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Inhibition of hepatic microsomal triglyceride transfer protein – a novel therapeutic option for treatment of homozygous familial hypercholesterolemia
... of microsomal triglyceride transfer protein Background The microsomal triglyceride transfer protein (MTTP) is obligatory for the formation of very-low-density ...
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Genetic variation in the microsomal triglyceride transfer protein (−493G/T) is associated with hepatic steatosis in patients infected with hepatitis C virus
... Keywords: Hepatic steatosis, Chronic hepatitis C, Microsomal triglyceride transfer protein (MTTP), Single nucleotide polymorphism (SNP) * Correspondence: [email protected] 1 ...
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JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, ameliorates lipid metabolism and attenuates atherosclerosis in hyperlipidemic animal models
... Microsomal triglyceride transfer protein (MTP) has been known to take part in the mobilization and secretion of triglyceride-rich lipoprotein, such as chylomicrons in enterocytes and ...
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Microsomal triglyceride transfer protein gene -493G/T polymorphism and its association with serum lipid levels in Bama Zhuang long-living families in China
... [4]. Microsomal triglyceride transfer protein (MTP, or MTTP) is a heterodimeric lipid transfer protein mainly present in hepatocytes, enterocytes and myocytes which transfers ...
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Supplementary site interactions are critical for the regulation of microsomal triglyceride transfer protein by microRNA-30c
... Com- parative analysis of the miR-30 family members and their possible interactions with MTTP mRNA revealed that these two molecules could form complementary base pairing involving dispa[r] ...
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Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function
... Interestingly, while group 1 CD1 expression is considerably reduced in ABL as shown here, the CD1 molecules that pre- sumably escape proteasomal degradation exhibit a normal intracellular distribution of expression. It ...
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Hepatic steatosis in hepatitis C is a storage disease due to HCV interaction with microsomal triglyceride transfer protein (MTP)
... core protein induces hepatic fat accumulation in mice by inhibiting MTP activity, leading to impaired secretion of VLDL ...and protein activity in liver biopsy specimens from a series of untreated patients ...
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Cholesterol absorption status and fasting plasma cholesterol are modulated by the microsomal triacylglycerol transfer protein −493 G/T polymorphism and the usual diet in women
... eride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene ...(2006) Microsomal triglyceride transfer protein -493T variant reduces IDL plus ...
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FoxO3 regulates hepatic triglyceride metabolism via modulation of the expression of sterol regulatory-element binding protein 1c
... and microsomal triglyceride transfer protein (MTTP) are the key regulators ...SCD1 protein expression ...the protein levels of SREBP1c and SCD1 ...
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Lipid Transfer Protein
... An Novel Enzyme-linked Immunosorbent Assay for Barley Lipid Transfer Protein as a Quality Control System of Beer Yukie Murakami-Yamaguchi, Junko Hirose*, Wataru Fujii** and Hiroshi Narit[r] ...
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The adipsin acylation stimulating protein system and regulation of intracellular triglyceride synthesis
... stimulates triglyceride synthesis in cultured human skin fibroblasts and human ...purified protein is a fragment of the third component of plasma complement, ...of triglyceride synthesis in ...
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Human ApoA II inhibits the hydrolysis of HDL triglyceride and the decrease of HDL size induced by hypertriglyceridemia and cholesteryl ester transfer protein in transgenic mice
... ester transfer protein (CETP) mediates the exchange of HDL cholesteryl esters with triglycerides of other ...the triglyceride-enriched HDL by hepatic lipase leads to reductions of HDL size and apoA-I ...
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Characterization and isolation of thyroid microsomal antigen
... We investigated the structure of the 107-kD thyroid protein recognized as microsomal antigen. Solubilized microsomes were incubated with affinity gels consisting of IgG, from thyroiditis patients or ...
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An extrahepatic receptor-associated protein-sensitive mechanism is involved in the metabolism of triglyceride-rich lipoprotein.
... the protein mass and catalytic activity of hepatic lipase and lipoprotein lipase in RAP overexpressing ...large triglyceride- rich chylomicrons to smaller remnants by interfering with LPL activation in the ...
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The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins.
... Results: PID1 co-localized in perinuclear endosomes and was found associated with LRP1 under fasting conditions. We identi fied the distal NPxY motif of the intracellular C-terminal domain (ICD) of LRP1 as the site ...
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Apolipoprotein CIII may mediate the impacts of angiopoietin-like protein 8 on triglyceride metabolism
... (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), HDL-C, apoAI, apoB, free fatty acid (FFA), were evalu- ated via an automated analyzer (Hitachi ...C-reactive protein (hsCRP) were ...
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Reductive metabolism of oxymatrine is catalyzed by microsomal CYP3A4
... The embedded figures are Eadie–Hofstee plots for the same data. Rhombuses and smooth lines denote the observed and predicted rates of OMT metabolism, respectively. Microsomal protein concentration was 0.1 ...
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Is Transfer Learning Necessary for Protein Landscape Prediction?
... In this paper, we show that CNN models trained solely using supervised learning both compete with and sometimes outperform the best models from TAPE that leverage expensive pretraining on large protein datasets. ...
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Regulation of microsomal prostaglandin E2synthase 1 and 5 lipoxygenase activating protein/5 lipoxygenase by 4 hydroxynonenal in human osteoarthritic chondrocytes
... Results: Single addition of 10 μ M HNE to cultured chondrocytes induced PGE 2 release as well as COX-2 and mPGES-1 expression at the protein and mRNA levels, with a plateau reached respectively at 8 and 16 hours ...
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