Microtubule Dynamics
Measuring microtubule dynamics
... labelled microtubule-associated proteins (MAPs) such as EB3 ...the microtubule ends can be tracked directly in the timelapse movie, but it is more common to gener- ate kymographs and trace the path of the ...
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Kinesin-13 Regulates Flagellar, Interphase, and Mitotic Microtubule Dynamics in Giardia intestinalis
... spindle microtubule dynamics but also flagellar ...of microtubule depoly- merization at the flagellar tip by kinesin-13 may be a wide- spread and evolutionarily conserved mechanism important for ...
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Sphingosine Kinase Regulates Microtubule Dynamics and Organelle Positioning Necessary for Proper G1/S Cell Cycle Transition in Trypanosoma brucei
... of microtubule dynamics in cell division, we analyzed cells for the distribution of newly polymerized tyrosi- nated ␣-tubulin in TbSPHK-depleted cells, which revealed both an accumulation of tubulin and an ...
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Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression
... Here, based on findings that mice entirely deficient of tau expression are quite viable [17,18] and the notion that generally reducing the pool of tau available for further aggregation may hold therapeutic potential ...
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PAK4 Regulates Actin and Microtubule Dynamics during Meiotic Maturation in Mouse Oocyte
... and microtubule dynamics. PAK4 inhibition impaired the microtubule stability and led to the defective kinetochore-microtubule (K-M) attachment which inevitably resulted in ...
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Regulation of microtubule dynamics by microtubule associated protein expression and phosphorylation during neuronal development
... Int J De\" BinI 38 13 25 (1994) 13 Review Regulation of microtubule dynamics by microtubule associated protein expression and phosphorylation during neuronal development JESUS AVllA*, JORGE DOMiNGUEZ[.] ...
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Adenomatous polyposis coli mutants dominantly activate Hsf1- dependent cell stress pathways through inhibition of microtubule dynamics
... of microtubule dynamics in cell stress pathway activation, we used either micromolar or nanomolar concentrations of the microtubule poison, nocodazole to differentially perturb microtubule ...
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Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics
... KIF7 interacts with the JBTS4 protein NPHP1. Since several human ciliopathy proteins function in multiprotein complexes to regu- late cilia formation, microtubule dynamics, or Golgi structure, we tested ...
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Tankyrase inhibition impairs directional migration and invasion of lung cancer cells by affecting microtubule dynamics and polarity signals
... by microtubule dynamics; regardless of context-dependent idiosyncratic differ- ences, it is apparent that during productive cell locomo- tion the centrosome relocates in front of the nucleus facing the ...
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Microtubule polyglutamylation and acetylation drive microtubule dynamics critical for platelet formation
... released. Microtubule dynamics, bundling, sliding, and coiling, drive these dramatic morphological changes whose regulation remains poorly ...understood. Microtubule properties are defined by tubulin ...
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Escape from Mitotic Arrest: An Unexpected Connection Between Microtubule Dynamics and Epigenetic Regulation of Centromeric Chromatin in Schizosaccharomyces pombe
... a microtubule-associated protein that in fl uences microtubule dynamics, lead to mitotic arrest as a result of an active SAC and consequent failure to grow at low ...
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Cytoplasmic Dynein and Dynactin Coordinate Microtubule Dynamics at the Growing Plus End
... dynactin. Microtubule dynamics are strongly influenced by microtubule-associated proteins, which bind to microtubules and bias them toward growth or ...the microtubule plus end and to the ...
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The Characterization of the Fibroblast Growth Factor Receptor Substrate 3 and its role in Regulating Microtubule Dynamics and Molecular Transport in the Brain
... a microtubule-binding protein and only a minor amount is present in membrane fractions (Hryciw et ...and microtubule stability) but also with III tubulin, a marker of post-mitotic neurons (Hryciw et ...
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Growth cone-specific functions of XMAP215 in restricting microtubule dynamics and promoting axonal outgrowth
... In this study, we identify new functions for the well- studied MT regulator XMAP215 in axon outgrowth and growth cone MT dynamics (summarized in Figure 5). While it was previously reported that axon outgrowth ...
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Supplemental Information. Daple Coordinates Planar Polarized. Microtubule Dynamics in Ependymal Cells. and Contributes to Hydrocephalus
... Wild-type or Daple-deficient mice at P21 were injected with 2% Evans Blue into the right LV under. anesthesia[r] ...
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p27kip1 at the crossroad between actin and microtubule dynamics
... Recent evidences confirm that p27 exerts an impor- tant function on cytoskeleton, controlling actin and MT dynamics (Fig. 1). This function is carried out by binding and modulating the activity of many differ- ent ...
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MICROTUBULE: A NOVEL TARGET FOR CANCER THERAPY
... therapy, microtubule network is an attractive cellular ...rapid microtubule dynamics also play a critical role for activities of the bipolar ...spindle. Microtubule targeting drugs act at ...
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The Evolution of Microtubule End Binding Protein 1 (EB1) and Roles in Regulating Microtubule Behavior
... Spindle dynamics through depolymerization or polymeriza- tion of microtubules generates the driving force required for chromosome movements in ...that microtubule arrays control the directions of cell ...
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Microtubule Motors Drive Nuclear Dynamics and Positioning in Developing Skeletal Muscle Cells
... nuclear dynamics that we observe in the immortalized C2C12 mouse muscle cell line accurately recapitulate the descriptions provided in the earlier works (Capers, 1960; Cooper and Konigsberg, 1961; Englander and ...
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Microtubule organization, dynamics and functions in differentiated cells
... Microtubule dynamics include growth rates and lifetimes at both the microtubule plus and minus ends as well as catastrophe, pause and rescue frequencies, which in addition to microtubule ...
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