microvascular endothelial cell
Cytokine-induced changes in the gene expression profile of a human cerebral microvascular endothelial cell-line, hCMEC/D3
... Cerebral endothelial cells (CEC) constitute the major element of the highly specialized vasculature of the central nervous system (CNS) that contributes to the blood–brain barrier ...cerebral microvascular ...
6
Uptake of Neisserial autotransporter lipoprotein (NalP) promotes an increase in human brain microvascular endothelial cell metabolic activity
... increase in human brain microvascular endothelial cell metabolic activity.. Dufailu, Jafar Mahdavi, Dlawer A.[r] ...
20
TWEAK/Fn14 pathway modulates properties of a human microvascular endothelial cell model of blood brain barrier
... The importance of TWEAK in brain pathology is fur- ther evidenced by data proving that TWEAK blocking antibodies or Fn14 decoy receptors are efficient in ani- mal models of ischemic stroke and brain edema [17-19]. ...
14
Original Article ASK1 induces retinal microvascular endothelial cell apoptosis through ER stress-associated pathway
... major microvascular complication in patients with diabetes mellitus; it can cause a variety of eye problems in a high percentage of diabetic ...in microvascular endothelial ...Apoptotic cell ...
9
Niacin and microvascular endothelial cell response to fatty acid excess and hypoxia
... improves endothelial cell function under lipotoxic and low oxygen conditions, as seen in ischemic conditions during metabolic syndrome, and investigated the potential mechanism ...Human microvascular ...
96
The influence of capsaicin on the integrity of microvascular endothelial cell monolayers
... epithelial cell layers ...open endothelial cell ...the microvascular system can increase after application ...murine microvascular endothelial cells to capsaicin and its ...
10
Hydrocortisone enhances the barrier properties of HBMEC/ciβ, a brain microvascular endothelial cell line, through mesenchymal-to-endothelial transition-like effects
... Considering that GR is a transcription factor, it is rea- sonable to assume that GR activation enhances EPAC and RAP1 mRNA levels in order to expand their poten- tial activity upon stimulation, but it is difficult to ...
15
The Metalloproteinase-Dependent Role of TIMPs in Regulation of Pulmonary Microvascular Endothelial Cell Barrier Function During Sepsis
... Solely male murine PMVEC were used for the current study; however, there is much evidence of sex specific differences in human sepsis (i.e. septic females are less susceptible to organ dysfunction and death). Men are ...
138
Growth-factor reduced Matrigel source influences stem cell derived brain microvascular endothelial cell barrier properties
... stem cell-based models of the human BBB brought a com- plementary approach to other in vitro models based on human primary cultures or on the hCMEC/D3 immor- talized cell line [7–9, 11, ...
7
Role of pulmonary microvascular endothelial cell apoptosis in murine sepsis-induced lung injury in vivo
... septic microvascular/ MVEC ...pulmonary microvascular/PMVEC barrier dysfunction and PMVEC death/apoptosis followed parallel time courses; (b) there were strong correlations between in vivo septic pulmonary ...
13
Septic Murine Pulmonary Microvascular Endothelial Cell Barrier Dysfunction is Regulated by Tissue Inhibitor of Metalloproteinases 3
... juxtamembrane domain of VE-cadherin, is a very important determinant of VE-cadherin stabilization. p120 phosphorylation results in cadherin disassembly and internalization, along with increased cytoplasmic p120 content ...
119
Comparison of apoptosis in human primary pulmonary endothelial cells and a brain microvascular endothelial cell line co cultured with Plasmodium falciparum field isolates
... Apoptosis was measured with an enzyme immunoassay (Cell Death Detection ELISA plus, Roche Diagnostics) as recommended by the manufacturer. This ELISA detects cytoplasmic nucleosomes released from apoptotic cells ...
10
<p>The role of tissue inhibitors of metalloproteinases in microvascular endothelial cell barrier dysfunction during sepsis</p>
... cytokines, cell surface leukocyte receptors, such as ICAM1 and VCAM1, and of extracellular enzymes known to regulate inflammatory signaling pathways, such as the matrix metalloproteinases (MMPs) and closely ...
12
Regulation of β-Adrenergic Receptor Trafficking and Lung Microvascular Endothelial Cell Permeability by Rab5 GTPase
... the cell surface receptors, including G protein-coupled β-adrenergic receptors ...lung microvascular endothelial cells (LMECs) and in maintaining the integrity and permeability of endothelial ...
11
RIPK3 Regulates Microvascular Endothelial Cell Necroptosis and Cardiac Allograft Rejection
... Apoptotic cell death has been extensively studied in cancer, infectious disease, autoimmune disease and transplantation 117, 118 ...otherwise. Endothelial cell apoptosis has been shown to be an ...
108
Role of chemerin, a novel adipochemokine, in the human microvascular endothelial cell (HMEC) 1 line
... HMEC-1 cell supernatants in a concentration-dependent manner after 24 hours HMEC-1 cells were treated with chemerin (21-157) [0-10nM] for 24 hours and cell supernatants were ...of cell supernatants ...
352
Brain microvascular endothelial cell association and distribution of a 5 nm ceria engineered nanomaterial
... Light and electron microscopy were used to confirm BBB integrity and determine the localization of ceria ENM in the endothelial cells and/or brain parenchyma. Light microscopy examination of the choroid plexus ...
14
The effects of hyperoxia on microvascular endothelial cell proliferation and production of vaso-active substances
... Furthermore, hyperoxia can cause significant hemodynamic alterations [2, 3] and has been reported to induce vasoconstriction in several (cerebral, coronary, skeletal muscle, and retinal) [14 – 17], but not all (renal, ...
17
Role of iNOS in septic pulmonary microvascular endothelial cell activation
... Evidences suggested that there is an interaction between iNOS, cytoskeleton and junctional proteins and protein leak. iNOS is induced by LPS and cytokines TNF alpha and IFN gamma. iNOS plays an important role in ...
218
CD4+ T-cell Mediated Microvascular Endothelial Cell Death and Chronic Cardiac Allograft Rejection Involves Necroptosis
... In contrast, necrosis has historically been regarded as passive or accidental cell death as a result of nonspecific stress factors such as extreme heat, freeze-thawing, or osmotic shock. Upon membrane rupture, ...
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