miR-125a
MiR-125a suppresses tumor growth, invasion and metastasis in cervical cancer by targeting STAT3
... that miR-125a directly targeted STAT3 and inhibited its ...by miR- 125a overexpression. Moreover, a high expression level of miR-125a was correlated with less aggressive behavior ...
15
lncRNA CASC9 regulates cell migration and invasion in hemangioma endothelial cells by targeting miR-125a-3p/Nrg1
... Total RNA was extracted from HA tissues and normal skin tissue using the TRIzol reagent (Thermo Fisher Scientific, Inc.) according to the manufacturer’s instructions. For miRNA analysis, RT-qPCR was performed using the ...
10
IL-16/miR-125a axis controls neutrophil recruitment in pristane-induced lung inflammation
... of miR-125a mimic reduces neutrophil recruitment and IL-16 expression and attenuates pristane-induced lung ...a miR-125a mimic or negative control (n = 10 for each treatment group) for 1 day ...
16
The E2F3/miR-125a/DKK3 regulatory axis promotes the development and progression of gastric cancer
... example, miR‑31 inhib‑ its tumour invasion and metastasis by targeting RhoA in human GC [11]; miR‑6852 suppresses cell prolifera‑ tion and invasion by targeting forkhead box J1 (FOXJ1) in GC [12]; and ...
12
Original Article MiR-125a suppresses ovarian cancer proliferation and motility by targeting HDAC4
... that miR- 125a was down-regulated in ovarian cancer. Furthermore, miR-125a targets HDAC4 and inhibited the expression of HDAC4 both at the mRNA and protein ...of miR-125a ...
7
Circular RNA circVAPA knockdown suppresses colorectal cancer cell growth process by regulating miR-125a/CREB5 axis
... of miR-125a and CREB5 were involved in the development of CRC [17, 22, ...modulating miR-125a/CREB5 axis. Rescue assays verified that miR-125a silencing or CREB5 overexpression ...
11
miR-125a-5p suppresses colorectal cancer progression by targeting VEGFA
... All experiments were performed in triplicate, and statis- tical analysis was performed using SPSS 19.0 software (Chicago, IL, USA). Differences between the two groups were evaluated using Student’s t-test (two-tailed), ...
15
Inhibition of HAX-1 by miR-125a reverses cisplatin resistance in laryngeal cancer stem cells
... of miR-125a in laryngeal cancer stem cells. We demonstrated that miR-125a was decreased in laryngeal cancer stem cells and the absence of miR-125a was responsible for the ...
11
<p>Epigenetics mechanisms mediate the miR-125a/BRMS1 axis to regulate invasion and metastasis in gastric cancer</p>
... and miR-125a in data from the Chipbase datasets and by qPCR analyses of 31 paired GC ...potential miR-125a target. Moreover, overexpression or inhibition of miR-125a did not in fl ...
13
<p>Upregulation of TRIAP1 by the lncRNA MFI2-AS1/miR-125a-5p Axis Promotes Thyroid Cancer Tumorigenesis</p>
... 4 miR-125a-5p targets TRIAP1 directly. (A) Binding site with miR-125a-5p in TRIAP1 and strategy for luciferase reporter ...C) miR-125a-5p inhibited the luciferase activity of ...
8
<p>The lncRNA HOXA11-AS regulates Rab3D expression by sponging miR-125a-5p promoting metastasis of osteosarcoma</p>
... of miR-125a-5p was negatively cor- related with that of HOXA11-AS and ...while miR-125a-5p had a negative regulatory effect on the invasiveness of OS cell ...
14
<p>FNDC3B, Targeted by miR-125a-5p and miR-217, Promotes the Proliferation and Invasion of Colorectal Cancer Cells via PI3K/mTOR Signaling</p>
... Meanwhile, miR-125a-5p and miR-217 were proved to regulate FNDC3B expression by directly binding to the 3`UTR of FNDC3B, thus to involve in cell prolifera- tion and invasion of ...of ...
10
<p>The lncRNA BCYRN1 Functions as an Oncogene in Human Glioma by Downregulating miR-125a-5p in vitro</p>
... on miR-125a-5p (Figure ...with miR-125a-5p in U251 cells (Figure 3B and ...of miR-125a-5p, the same negative relationship was found between BCYRN1 and miR-125a-5p ...
11
<p>LncRNA miR143HG Up-Regulates p53 In Endometrial Carcinoma By Sponging miR-125a</p>
... that miR-125a can bind miR143HG (Figure 2A). Expression levels of miR-125a and its downstream target p53 mRNA were in EC cells were measured by ...and miR-125a/p53 were analyzed ...
7
miR-125a restrains cell migration and invasion by targeting STAT3 in gastric cancer cells
... with miR-125a mimic groups, but no significant difference had been found in SGC7901 ...between miR- 125a and STAT3, MKN45 and NCI-N87 were chosen and transfected with miR-125a ...
11
Original Article Role of miR-125a in intervertebral degenerative disc disease and related mechanisms
... functions. MiR has multiple functional mechanisms and can regulate body growth/development, cell growth, proliferation and ...forms, miR can be regulated by physiological and developmental signals [13, ...
8
miR-125a suppresses viability and glycolysis and induces apoptosis by targeting Hexokinase 2 in laryngeal squamous cell carcinoma
... of miR-125a and HK2 mRNA in LSCC tissues, total RNA of LSCC tissues form 23 patients (11 Stage 1, 2 and 12 Stage 3, 4) was extracted and reverse-transcripted into cDNA, then qRT-PCR anal- ysis was ...that ...
11
miR-125a-5p post-transcriptionally suppresses GALNT7 to inhibit proliferation and invasion in cervical cancer cells via the EGFR/PI3K/AKT pathway
... of miR-125a-5p, we transfected miR-125a-5p mimic and NC-mimic into HeLa and Caski cells and detected the expression levels of ...that miR-125a-5p levels were mark- edly ...
13
<p>miR-125a-5p inhibits colorectal cancer cell epithelial–mesenchymal transition, invasion and migration by targeting TAZ</p>
... Total RNA was extracted from LoVo and SW480 cells using Trizol reagent (Invitrogen, USA) and miRNeasy extraction kit (Qiagen; Germantown, MD) according to the manufacturer ’ s instructions. Single-stranded cDNA was ...
9
miR-125a-5p is a prognostic biomarker that targets HDAC4 to suppress breast tumorigenesis
... of miR-125a-5p induces apoptosis through p53 activation in lung cancer ...inhibiting miR- 125a-5p increases MMP11 and VEGFA protein expression, while restoring miR-125a-5p ...
16