miR-129
Down-regulation of miR-129-5p via the Twist1-Snail feedback loop stimulates the epithelial-mesenchymal transition and is associated with poor prognosis in breast cancer
... of miR-129-5p on cell proliferation by transfecting miR-129-5p inhibitor or mimic in MCF7 and MDA-MB-231 cell lines (Figure ...1B). miR-129-5p inhibition resulted in a higher ...
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Original Article Downregulation of miR-129 in peripheral blood mononuclear cells is a diagnostic and prognostic biomarker in prostate cancer
... the miR-221 is also progressively down-regulated in prostate cancer patients with lymph node-metastasis and is employed as a biomarker for clinical prognosis of prostate cancer patients at high-risk ...the ...
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Original Article Role of miR-129 in myocardial cells of hypertensive heart disease mouse
... of miR-129 in cardiomyocytes from hy- pertensive heart disease mouse was signifi- cantly higher than that of sham-operated ...of miR-129 resulted in apoptosis of cardiomyocytes from ...
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LncARSR sponges miR-129-5p to promote proliferation and metastasis of bladder cancer cells through increasing SOX4 expression
... Emerging evidences have indicated that long non-coding RNAs (lncRNAs) are potential biomarkers, playing important roles in the development of cancer. LncRNA Activated in RCC with Sunitinib Resistance (lncARSR) is a novel ...
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Autophagic digestion of Leishmania major by host macrophages is associated with differential expression of BNIP3, CTSE, and the miRNAs miR 101c, miR 129, and miR 210
... As outlined in Fig. 11, the experimental results of the current study clearly demonstrated that (1) autophagy was induced in L. m.-infected BMDM in the early and in the late infection phase; (2) autophagy induction was ...
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<p>miR-129-5p inhibits prostate cancer proliferation via targeting ETV1</p>
... detect miR-129-5p expression in tumor tissues and adjacent normal tissues from patients with prostate ...of miR-129-5p in mediating prostate cancer cell ...of miR-129-5p. ...
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miR-129 as a novel therapeutic target and biomarker in gastrointestinal cancer
... of miR-129 expression is significantly associ- ated with disease progression in colo rectal cancer, gastric cancer, and liver ...result, miR-129 has the potential to be used as a companion ...
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<p>LINC00501 Inhibits the Growth and Metastasis of Lung Cancer by Mediating miR-129-5p/HMGB1</p>
... (miR- 129-5p-mimics), inhibitors (miR-129-5p-inhibit), and their respective controls (miR-NC) were all processed by RiboBio (Guangzhou, ...
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<em>MALAT1 </em>promotes proliferation, migration, and invasion of MG63 cells by upregulation of <em>TGIF2 </em>via negatively regulating <em>miR-129</em>
... of miR-129 mimics group, they had markedly lower cell viability, migration, and invasive cell numbers than miR-129 NC group ...(P,0.01). miR-129 was targetedly and negatively ...
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miR-129-3p controls centrosome number in metastatic prostate cancer cells by repressing CP110
... miR-129-3p is overexpressed in metastatic PCa To identify miRNAs involved in PCa metastasis, we used the Dunning rat PCa progression model [20]. Two successive stages of progressive PCa were selected, i.e. ...
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LncRNA KCNQ1OT1 promotes cell proliferation, migration and invasion via regulating miR-129-5p/JAG1 axis in non-small cell lung cancer
... and miR- 129-5p or miR-129-5p and JAG1 were predicted by LncBase Predicted ...of miR-129-5p were inserted into pGL3 luciferase reporter plasmids (Promega, Madison, WI, USA), and ...
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Original Article Activation of NF-кB by miR-129 and enhancement of neuroglioma growth
... NF-кB is one nuclear transcription factor exist- ed in multiple cells with pluripotent regulatory functions, and is usually formed in homo-/het- ero-dimer in cytoplasm. P50/p65 heterodimer is the most common binding way ...
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Long noncoding RNA LINC00314 facilitates osteogenic differentiation of adipose-derived stem cells through the hsa-miR-129-5p/GRM5 axis via the Wnt signaling pathway
... putative miR-129-5p targeting site was amplified by chemical synthesis and was inserted into the psi- CHECK2 vector (Promega, Madison, WI, ...plasmids, miR-129-5p mimics, or ...
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Original Article miR-129-3p inhibits NHEJ pathway by targeting SAE1 and represses gastric cancer progression
... of miR-129-3p in GC tumor when compared with adja- cent non-tumor tissues, and the peripheral blood exosome miR-129-3p level was also reduced when compared with healthy ...that ...
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Methylation-associated silencing of microRNA-129-3p promotes epithelial-mesenchymal transition, invasion and metastasis of hepatocelluar cancer by targeting Aurora-A
... them, miR- 129-3p was one of the most downregulated ...Meanwhile, miR- 129-5p and 3p are originated from ...of miR-129 family members is a frequent event in many human ...three ...
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Inactivation of the Wnt/β-catenin signaling pathway underlies inhibitory role of microRNA-129-5p in epithelial–mesenchymal transition and angiogenesis of prostate cancer by targeting ZIC2
... database, miR-181a, miR-181b, and miR-181c were all found to bind to ZIC2 at the same location, and they were found to have multiple binding sites on ...of miR-96-5p and ZIC2 was − 0.3957, ...
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Methylation-mediated repression of microRNA-129-2 suppresses cell aggressiveness by inhibiting high mobility group box 1 in human hepatocellular carcinoma
... in miR-129-2- overexpressing ...in miR-129-2- overexpressing cells (Figure ...in miR-129-2-overexpressing cells (Figure 7B), which validated that miR-129-2 ...
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Inhibition of ZEB1-AS1 confers cisplatin sensitivity in breast cancer by promoting microRNA-129-5p-dependent ZEB1 downregulation
... that miR-34a overexpression attenuated cell proliferation and migration which critically enhanced apoptosis in breast cancer by decreasing Bcl-2 expres- sion ...that miR-129 overex- pression inhibits ...
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<p>Targeting ZEB2 By microRNA-129 In Non-Small Cell Lung Cancer Suppresses Cell Proliferation, Invasion And Migration Via Regulating Wnt/β-Catenin Signaling Pathway And Epithelial–Mesenchymal Transition</p>
... example, miR-411 was found to inhibit the malignant behaviors in colorectal carcinoma via regulation of PIK3R3; 7 dysregulation of miR-567 could contribute to carci- nogenesis of breast cancer; 8 ...
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A novel role for microRNA-129-5p in inhibiting ovarian cancer cell proliferation and survival via direct suppression of transcriptional co-activators YAP and TAZ
... the miR-34a mimic compound, MRX34, which has successfully advanced into a Phase I human clinical trial for liver cancer ...that miR-129-5p robustly downregulates endogenous YAP and TAZ expression and ...
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