miR-137
HEY2, a target of miR-137, indicates poor outcomes and promotes cell proliferation and migration in hepatocellular carcinoma
... HEY2, a bHLH transcription factor, has been implicated in the progression of human cancers. Here, we showed that HEY2 expression was markedly increased in HCC, compared with the adjacent nontumorous tissues. High HEY2 ...
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Original Article Upregulation of miR-137 protects anesthesia-induced hippocampal neurodegeneration
... of miR-137 was modulated during the process of ketamine-induced hippocampal neu- ...hippocampal miR- 137 messenger RNA was examined by qRT- PCR, and compared with the expression level of ...
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MiR 137 derived polygenic risk: Effects on cognitive performance in patients with schizophrenia and controls
... higher miR-137 polygene scores at all P-value ...single miR-137 risk SNP rs1702294 only showed signi fi cant in fl uence on three domains: IQ, attention, and a ToM measure (Table 3; P-values ...
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Epigenetic silencing of miR-137 contributes to early colorectal carcinogenesis by impaired Aurora-A inhibition
... of miR-137 was found in many cancers, such as melanoma, head and neck carcinoma, breast cancer, gastric cancer and CRC, by inhibiting cancer cell proliferation, metastasis and invasion [16, ...of ...
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miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells
... lineages: miR-7 during pho- toreceptor differentiation [23]; miR-124 and miR-137 during erythropoiesis [24]; miR-124 and miR-218 during neuronal differentiation of embryonal ...
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MiR-137 and miR-34a directly target Snail and inhibit EMT, invasion and sphere-forming ability of ovarian cancer cells
... of miR-137 and miR-34a and increased expression of Snail when compared to their adjacent normal tissues, and lower miR-137 and miR-34a expression correlates with worse patient ...
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Original Article Expression and effects of miR-137 in patients with erectile dysfunction
... (e.g., miR-137) is altered to some ...of miR-137 expression in patients with ED in an effort to find more suit- able gene therapy options or stem cell trans- plantation ...
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Original Article MiR-137 regulates the proliferation and invasion of glioma cells through EZH2/Wnt/β-catenin signaling pathway
... of miR-137 in the progression of ...of miR-137 was decreased in glio- ma tissues and cell ...of miR-137 suppressed glioma cell prolifera- tion, migration and invasion in ...of ...
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<p>miR-137-3p Modulates the Progression of Prostate Cancer by Regulating the JNK3/EZH2 Axis</p>
... reported, miR-137 was confirmed to target KDM4A and functions as a key mediator inhibiting cancer growth, migration and ...addition, miR-137 plays a key role in several cancer types, including ...
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Original Article miR-137 regulates testosterone secretion in Leydig cells of rats by Kiss-1
... of miR-137 on secretion of testosterone in Leydig cells of rats by ...that miR-137 bound to the 3’UTR region of Kiss-1 gene. Conclusion: miR-137 may inhibit the secretion of ...
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<p>OIP5-AS1/miR-137/ZNF217 Axis Promotes Malignant Behaviors in Epithelial Ovarian Cancer</p>
... 3p, miR-2682-5p and miR-137) were revealed to bind to ...result, MiR-137 exhibited a signi fi cant down-regulation in EOC tissues compared with normal tissues (Figure ...of ...
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Long noncoding RNA 00976 promotes pancreatic cancer progression through OTUD7B by sponging miR-137 involving EGFR/MAPK pathway
... of miR- NAs to ...potential miR-137 binding sites ...that miR-137 is downregulated and inhibits the growth, invasion, stem- ness in PC cell ...that miR-137 expression was ...
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Downregulation of miR-137 and miR-6500-3p promotes cell proliferation in pediatric high-grade gliomas
... by miR-137, while KIF14 and NCAPG expression are inhibited by miR-6500-3p, and an anti-tumor effect was achieved by combining TMZ with either miR137 or ...
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Original Article MiR-137 silencing of BRD4 suppresses oral squamous cell carcinoma cells proliferation, migration and invasion
... of miR-137 in oral squamous cell carcinoma ...of miR-137 was detected in OSCC tissues and cell lines by using ...with miR-137 mimics and mimic ...of miR- 137 was ...
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Original Article miR-137 functions as a tumor suppressor gene in pituitary adenoma by targeting AKT2
... All data were expressed as the mean ± standard deviation. All statistical analyses were per- formed using Graphpad Prism version 7.0 (GraphPad Sof- tware, Inc., La Jolla, CA, USA). The differences between two groups were ...
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<p>Knockdown Of lncRNA NCK-AS1 Regulates Cisplatin Resistance Through Modulating miR-137 In Osteosarcoma Cells</p>
... that miR-137 acted as a tumor suppressor by targeting enhancer of zeste homolog 2 in ...Furthermore, miR-137 was proved to be downregulated in osteosarcoma and regulate cell proliferation and ...
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<p>LncRNA HOTTIP Participates in Cisplatin Resistance of Tumor Cells by Regulating miR-137 Expression in Pancreatic Cancer</p>
... HOTTIP), miR-137 low expression vector (miR-137-inhi- bitor), miR-137 over-expression vector (miR-137 mimic), blank vector miR-NC, blank vector si-NC, sh-NC, ...
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A contrasting function for miR-137 in embryonic mammogenesis and adult breast carcinogenesis
... gland. MiR-137 was expressed prominently in the developing mammary ...the miR-137 was over-expressed in the embryo, the mammary epithelium became ...that miR-137 induces gland ...
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Overexpression of mircoRNA-137 inhibits cervical cancer cell invasion, migration and epithelial–mesenchymal transition by suppressing the TGF-β/smad pathway via binding to GREM1
... of miR-137 binding to GREM1 on behaviors of CC cells, namely: blank (without transfection); NC (trans- fected with NC), miR-137 mimic (transfected with miR- 137 mimic), ...
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Repurposing phenformin for the targeting of glioma stem cells and the treatment of glioblastoma
... of miR-124, miR-137 and let-7 in the GSCs and that let-7 and miR-124 played a role in the inhibitory effect of phenformin on the self-renewal of these ...
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