miR-139-5p
Tumor-suppressor role of miR-139-5p in endometrial cancer
... example, miR-10b inhibits apop- tosis and promotes proliferation and invasion of EC cells via targeting HOXB3 ...[7]. MiR-135b can target FOXO1 to promote cell proliferation in EC cells ...
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<p>Knockdown of lncRNA TUG1 Enhances Radiosensitivity of Prostate Cancer via the TUG1/miR-139-5p/SMC1A Axis</p>
... TUG1, miR-139-5p and SMC1A expres- ...of miR-139-5p, overexpres- sion SMC1A could restore the effects of TUG1 knockdown on proliferation, apoptosis and radiosensitivity of PCa ...
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MiR-139-5p reverses CD44 /CD133 -associated multidrug resistance by downregulating NOTCH1 in colorectal carcinoma cells
... as miR-139-5p treatment (Figure ...that miR-139-5p reverses CD44+/ CD133+-associated MDR by downregulating ...of miR-139-5p mimics and NOTCH1 siRNA in ...
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MiR-139-5p/SLC7A11 Inhibits the Proliferation and Migration of Pancreatic Carcinoma via PI3K/Akt Signaling Pathway
... overexpressed miR-139-5p and Solute Carrier Family 7, Member 11 (SLC7A11) was established, and has been used to detect cell proliferation, migration, invasion and colony formation in ...of ...
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<p>Long Noncoding RNA X-Inactive Specific Transcript Facilitates Cellular Functions in Melanoma via miR-139-5p/ROCK1 Pathway</p>
... between miR-139-5p level and XIST ...of miR-139-5p in melanoma samples and reveals decreased miR-139-5p expression in melanoma tissues as compared with ...
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<p>LncSNHG3/miR-139-5p/BMI1 axis regulates proliferation, migration, and invasion in hepatocellular carcinoma</p>
... while miR-139-5p was ...or miR-139-5p overexpression could inhibit the proliferation, migration, and invasion in HCC ...that miR-139-5p was a target of ...
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Original Article MiR-139-5p protect against myocardial ischemia and reperfusion (I/R) injury by targeting autophagy-related 4D and inhibiting AMPK/mTOR/ULK1 pathway
... After treatment of H/R, the cell viability was sig- nificantly reduced, and the ratio of cell apopto- sis was noticeably increased as compared to the untreated cells (all P < 0.05, Figure 1A, 1B). The expression ...
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<p>miR-139-5p functions as a tumor suppressor in cervical cancer by targeting TCF4 and inhibiting Wnt/β-catenin signaling</p>
... of miR-139- ...of miR-139-5p and its negative impact on the Wnt/ β -catenin ...of miR-139-5p was fi rst constructed. We found that miR-139-5p ...
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LINC00152 promotes the growth and invasion of oral squamous cell carcinoma by regulating miR-139-5p
... In summary, the present study provided evidence that LINC00152 is upregulated in OSCC tissues, and its expres- sion is associated with TNM stage, lymph node metastasis, and poor survival of patients with OSCC. Knockdown ...
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Hsa-miR-139-5p inhibits proliferation and causes apoptosis associated with down-regulation of c-Met
... of miR-139-5p on A549 cells migration and ...of miR-139-5p on the ability of A549 and SK-MES-1 cells ...contrast, miR-139-5p-expressing cells migrated toward ...
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Targeting the Notch1 oncogene by miR-139-5p inhibits glioma metastasis and epithelial-mesenchymal transition (EMT)
... these, miR-139 inhibits the growth and metastasis of several cancers including myeloid leukaemia [12], laryngeal squamous carcinoma [13] and liver cancer through targeting, for example, c-Fos and CXCR4 [13, ...
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Original Article miR-139-5p suppresses the proliferation of oral squamous cellcarcinoma cells and targeting TPD52
... [7]. miR-139 is located on chromosome ...gene. MiR-139-5p is a common type of mature miRNA generated from a miR-139 pre-cursor ...of miR-139-5p in ...
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miR-139-5p regulates proliferation, apoptosis, and cell cycle of uterine leiomyoma cells by targeting TPD52
... incubated at 37 ° C for 24 hours. Medium was removed and 500 μ L of fresh medium was added, then 500 μ L of serum- and antibiotics-free medium containing miR-139- 5p mimics, NC or TPD52 siRNA and ...
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The “melanoma-enriched” microRNA miR-4731-5p acts as a tumour suppressor
... identified miR-4731-5p (miR-4731) as a melanoma-enriched microRNA following comparison of melanoma with other cell lines from solid ...Additionally, miR-4731 has been found in serum from ...
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<p>Long Non-Coding RNA LINC00511 Mediates the Effects of ESR1 on Proliferation and Invasion of Ovarian Cancer Through miR-424-5p and miR-370-5p</p>
... for miR-424-5p and miR-370-5p with Ago immunoprecipitation was calculated using the comparative Ct method, with samples normalized to input and compared to IgG ...
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Identification and validation of a four-miRNA(miRNA-21-5p, miRNA-9-5p, miR-149-5p, and miRNA-30b-5p) prognosis signature in clear cell renal cell carcinoma
... Four samples were removed because of lack of survival record in the training set. For each of the 138 differentially expressed miRNAs, we used the median expression level as a cutoff to stratify the remaining 237 ...
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Association of miR-497-5p and miR-4417 Expression in Oral Squamous Cell Carcinoma and Clinical Parameters
... of miR-21, miR- 125b-2*, miR-134, miR-155, miR-184, and miR-205 in oral squamous cell carcinoma and association with clinicopathological ...
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Epigenetic silencing of miR-145-5p contributes to brain metastasis
... of miR-145-5p expression (Supplementary Figure ...the miR-145- 5p precursor (Supplementary Figure S4D), implying that methylation release of the miR-145-5p regulatory region ...
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Decreased miR-155-5p, miR-15a, and miR-186 Expression in Gastric Cancer Is Associated with Advanced Tumor Grade and Metastasis
... of miR-186 in GC compared to GD and NG ...that miR-186 dysregulation is a late molecular change in GC ...that miR-186 acts as a tumor suppressor in several human cancers and also could modulate ...
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Prognostic value of miR-17-5p in cancers: a meta-analysis
... high miR-17-5p expression, rate of high miR-17-5p expression, follow-up period, age, gender, tumor depth, lymph node invasion, metastasis, vein invasion, histology differentiation, tumor size, ...
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