miR-148a
MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer
... of miR- 148a have been identified in various cancers, they mainly function in regulating cancer cell-autonomous behaviors [43, ...addition, miR-148a has been reported to suppress angiogenesis ...
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miR-148a Promoted Cell Proliferation by Targeting p27 in Gastric Cancer Cells
... for miR-148a ...of miR-148a ...whether miR-148a could directly regulate p27, p27 mRNA 3’UTR encompassing the predicted binding site with or without mutation that would disrupt ...
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Original Article miR-148a-3p exhaustion inhibits necrosis by regulating PTEN in acute pancreatitis
... and miR-148a-3p, uncovering that PTEN might be a direct target of miR-148a-3p (Figure ...and miR-148a-3p compared with the NC group, whereas there was little change of the ...
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Original Article MiR-148a suppresses invasion and induces apoptosis of breast cancer cells by regulating USP4 and BIM expression
... with miR- 148a or NC for 72 ...co-transfected miR-148a and BIM siRNA or control siRNA into MDA-MB-231 cells for 72 h, and detected BIM protein expression, survival and ...fected ...
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Original Article The effects of mesenchymal stem cell exosome with an overexpression of miR-148a on hepatic ischemia-reperfusion injury
... group, the model group, the experimental gr- oup, and the blank group. Moreover, the expr- essions of TLR4, CaMKII mRNA, and protein in the liver tissue of the overexpressing group were significantly lower than they were ...
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Dysregulation of NCAPG, KNL1, miR-148a-3p, miR-193b-3p, and miR-1179 may contribute to the progression of gastric cancer
... of miR-148a-3p can promote cell migration and proliferation in patients with laryn- geal squamous cell carcinoma ...addition, miR-148a is detected to be downregulated in human breast cancer ...
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Original Article miR-148a overexpression inhibits cell proliferation and induces cell apoptosis by suppressing the Wnt/β-catenin signal pathway in breast cancer MCF-7 cells
... that miR-148a expression was correlated to the breast cancer biological processes including cell viability and apoptosis, we therefore ana- lyzed the possible mecha- nism of its action (Figure ...
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Decreased expression and clinical significance of miR-148a in hepatocellular carcinoma tissues
... of miR-148a in the HCC tissues was detected than that in the adjacent noncan- cerous hepatic tissues (Table 1, Figure ...of miR-148a level in HCC. The area under the curve (AUC) of ...
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<p>miR-148a Regulates the Stem Cell-Like Side Populations Distribution by Affecting the Expression of ACVR1 in Esophageal Squamous Cell Carcinoma</p>
... Introduction: Esophageal squamous cell carcinoma (ESCC) is a malignant tumor disease with high mortality and morbidity rates, especially for a terminal cancer. At present, the prognosis and treatment of ESCC cannot ...
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Original Article miR-148a regulates inflammation in microglia induced by oxygen-glucose deprivation via MAPK signal pathways
... that miR-424 is significantly decreased in circulating lymphocytes of patients with isch- emic strokes ...Moreover, miR-146a is considered to be an intrinsic regulator of NF-κB, through which it ...
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Original Article Tumor-suppressive effect of miR-148a on salivary adenoid cystic carcinoma via down-regulation of MTA2
... mutant miR-148a tar- get sequences were cloned into the luciferase vectors ...mutant miR-148a (Mu) respectively. Co-transfection with miR- 148a, the luciferase activity of the ...
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Estradiol induces HOTAIR levels via GPER mediated miR 148a inhibition in breast cancer
... RNA was extracted using TRIzol. Total RNA (1 μg) was reverse-transcribed using a RevertAid First Strand cDNA Synthesis Kit (Fermentas). HOTAIR and miR-148a were measured using qRT-PCR (Roche). The ...
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Original Article Down regulation of miR-148a is related to enhanced pancreatic cancer pathogenesis through targeting GLUT1
... found miR-148a had a significantly down regulated expression and miR-148a level has an inverse correlation with the ex- pression of GLUT1 in PC ...that miR-148a suppressed GLUT1 ...
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Original Article MiR-148ainduces apoptosis by upregulating BIM expression in gastric cancer cells
... of miR-148a sensitized cells to TRAIL and reduced lung tumorigenesis in vitro and in vivo through the down-modula- tion of matrix metalloproteinase 15 (MMP15) and Rho-associated kinase 1 (ROCK1) ...of ...
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Investigating the mechanism of hepatocellular carcinoma progression by constructing genetic and epigenetic networks using NGS data identification and big database mining method
... (mir-148a, mir-374a and mir-494) in the MAPK and ErbB pathways cause cell proliferation, adhesions and migration and the immune cell infiltration to cancer cells during early ...and ...
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MicroRNA-148a suppresses proliferation and invasion potential of non-small cell lung carcinomas via regulation of STAT3
... Cells were seeded in 24-well plates and then co-transfected with miR-148a mimics or negative control and the mutant or wild type 3 ′ UTR of STAT3 using Lipofectamine 2000. Forty-eight hours after the ...
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Late-phase miRNA-controlled oncolytic adenovirus for selective killing of cancer cells
... from miR-148a binding to the inserted target sites but also from the recognition by all the miR-148/152 family members, since miR148a, miR-148b and miR-152 can recognize ...
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Clinical significance of promoter region hypermethylation of microRNA-148a in gastrointestinal cancers
... of miR-148a and clinicopathologic characteristics, which are associated with the proliferative and invasive behavior of ...of miR-148a in gastrointestinal cancers, and especially in gastric ...
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Hepatitis B virus X protein represses miRNA 148a to enhance tumorigenesis
... increased miR-148a expression ...that miR-148a expres- sion was downregulated in HCC tissue as compared with nontu- morous liver ...of miR-148a expression as well as miR- ...
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LncCCAT1 Promotes Breast Cancer Stem Cell Function through Activating WNT/β-catenin Signaling
... For MS2-based RIP assays, MCF-7 cells were co-transfected with pcDNA3.1-MS2, pcDNA3.1-MS2- CCAT1, pcDNA3.1-MS2-CCAT1-MUT and pMS2- GFP (Addgene). After 48h, cells were used to perform RNA immunoprecipitation (RIP) ...
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