miR-200b
Overexpression of lncRNA HOXA11-AS promotes cell epithelial–mesenchymal transition by repressing miR-200b in non-small cell lung cancer
... In the study, we found that lncRNA HOXA11-AS expression was up-regulated in NSCLC tissues and patients who had increased lncRNA HOXA11-AS expression had a shorter survival time. Furthermore, we demonstrated that ...
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Original Article Effect of miR-200b on retinal endothelial cell function under high glucose environment
... determine miR-200b mimics transfection effect on VEGF and TGFβ1 protein expression in hRECs and similar results with mRNA expression was ...after miR-200b mimics transfection (P < ...
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The tumor suppressive miR-200b subfamily is an ERG target gene in human prostate tumors
... of miR-200b/a/429 primary transcript after ERG knockdown, VCaP cells were transiently transfected with 50 nM of ERG ...of miR-200b/a/429 was determined by real-time qPCR using TaqMan Pri-miRNA ...
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miR 200b as a prognostic factor in breast cancer targets multiple members of RAB family
... of miR-200b between tumor tissues and para- carcinoma tissues was examined by independent samples ...between miR-200b expression and clinico-pathological parameters were examined by chi-square ...
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miR-200b is a key regulator of tumor progression and metabolism targeting lactate dehydrogenase A in human malignant glioma
... [26-28]. miR-200b, like the other members of the miR-200 family, is found to be dysregulated in multiple ...of miR-200b largely influences cell proliferation, cell cycle, cell invasion, ...
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miR-200b downregulates CFTR during hypoxia in human lung epithelial cells
... for miR-200b/200c at position 529 bases from the stop codon in the 3′UTR of CFTR mRNA ...of miR-200b and miR-200c was previously reported to be hypoxia-dependent in human endothelial ...
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Original Article miR-200b is associated with reduced lysyl oxidase in cervical portion of uterosacral ligaments in women with pelvic organ prolapse
... for miR-200b level by real-time quantitative PCR (RT-qPCR) method with Takara One Step RT-PCT kit (Takara, Tokyo, Japan) (for mRNA) or with mirVana™ qRT-PCR miRNA Detection Kit (Th- ermo Scientific, ...
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Long non-coding RNA ZEB1-AS1 regulates miR-200b/FSCN1 signaling and enhances migration and invasion induced by TGF-β1 in bladder cancer cells
... BLCA. miR-200b exerts a similar function in other types of cancer [26, ...of miR-200 family were increased in BLCA samples compared with normal tissues but de- creased in high grade and stage tumors ...
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Adipocyte miR-200b/a/429 ablation in mice leads to high-fat- diet-induced obesity
... The miR-200b/a/429 cluster has been functionally characterized in mammalian reproduction; however, the potential role of the miR-200 family in adipocytes is poorly ...of miR-200b/a/429 ...
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Loss of miR-200b promotes invasion via activating the Kindlin-2/integrin β1/AKT pathway in esophageal squamous cell carcinoma: An E-cadherin-independent mechanism
... of miR-200b [11], is one of the key molecules mediating the inside-out activation of integrin β1 [20, 21], and integrin β1 has been shown to activate the PI3K-AKT pathway [18, 19, 22, 23], we hypothesized ...
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Knockdown of circDENND4C inhibits glycolysis, migration and invasion by up-regulating miR-200b/c in breast cancer under hypoxia
... vector, miR-200b mimic (miR-200b) (5′-UAAUACUGCCUGGUAAUGAUGA-3′), miR-200c mimic (miR-200c) (5′-UAAUACUGCCGGGUAAUG AUGGA-3′), mimic negative control (miR-NC) (5′- ...
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Polycomb Repressive Complex 2 Regulates miR-200b in Retinal Endothelial Cells: Possible Implications in Diabetic Retinopathy
... the miR-200b promoter region in HG compared to NG controls (Figure ...the miR-200b promoter region in HG compared to NG controls (Figure ...and miR-200b at the level of chromatin ...
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Original Article Up-regulation of miR-200b by baicalin to inhibit migration of MCF-7 breast cancer cells
... Baicalin and MTT were purchased from Aladdin (Shanghai, China). MCF-7 cell was purchased from ATCC (MA, US). Real-time qPCR kit was purchased from TransGen (Beijing, China). Primers for miR-200b were ...
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Disruption of the c Myc/miR 200b 3p/PRDX2 regulatory loop enhances tumor metastasis and chemotherapeutic resistance in colorectal cancer
... of miR-200b-3p, we established LoVo/miR cells stably expressing miR-200b-3p, LoVo/ miR + PRDX2 cells stably co-expressing miR-200b-3p and nontargetable PRDX2 and ...
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Label free quantitative proteomics reveals the role of miR-200b in androgen-independent prostate cancer cells
... AIPC cell line PC3 and androgen-dependent prostate cancer (ADPC) cell line LnCap were obtained from the Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (Shanghai, China). A sub-line of LnCap named ...
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Role of AP-2α and MAPK7 in the regulation of autocrine TGF-β/miR-200b signals to maintain epithelial-mesenchymal transition in cholangiocarcinoma
... of miR-34a repressed the level of SNAIL via the miR-34a/b/c seed-matching sequence in the SNAIL 3′- UTR to induced EMT ...cancer, miR- 125a was found to be a negative regulator of EMT. miR- ...
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Diagnostic and prognostic relevance of circulating exosomal miR-373, miR-200a, miR-200b and miR-200c in patients with epithelial ovarian cancer
... exosomal miR-373 (p = 0.0001,), miR-200a (p = 0.0001), miR-200b (p = ...and miR-200c (p = ...whereas miR-141 and miR-429 were undetectable in exosomes (data not ...
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MiR-200b/200c/429 subfamily negatively regulates Rho/ ROCK signaling pathway to suppress hepatocellular carcinoma metastasis
... the miR-200 family can be categorized into two groups based on the chromosomal locations in which two different up- stream promoters are involved ...the miR- 200 family members are categorized into two ...
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Reduced miR-200b and miR-200c expression contributes to abnormal hepatic lipid accumulation by stimulating JUN expression and activating the transcription of srebp1
... of miR-200b and miR-200c might contribute to the sitagliptin-induced reduction of hepatic lipid accumulation in HFD-fed ...of miR-200b and miR-200c were increased in the livers ...
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Original Article Exosomal miR-200 family as serum biomarkers for early detection and prognostic prediction of cholangiocarcinoma
... that miR-200a/c-3p were not only diagnostic biomarkers but also signs representing the disease ...between miR-200a/c-3p and tumor ...exosomal miR-200a/c-3p levels than those with early stage ...
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