MiRNA Biogenesis and Function
Critical roles of RNA-binding proteins in miRNA biogenesis in Arabidopsis
... plants. miRNA levels are transcriptionally and post-transcription- ally controlled for their proper ...tween miRNA biogenesis and other RNA ...the function of several RNA-binding pro- teins in ...
6
Terminal loop-mediated regulation of mirna biogenesis: selectivity and mechanisms
... and function. The up- or down-regulation of the processing of specific miRNA precursors to the mature active form represents one tool to control miRNA concentration and is mediated by proteins that ...
5
The widespread regulation of microrna biogenesis, function and decay
... (miRNA) biogenesis through either protein–protein or protein–RNA ...regulate miRNA processing by decreasing DCGR8 ...influence miRNA target specificity 54–57 ...
14
Dual Regulation of miRNA Biogenesis Generates Target Specificity in Neurotrophin-Induced Protein Synthesis
... synaptic function, but how BDNF selectively affects only a minority of expressed mRNAs is poorly ...mature miRNA levels and inducing RNA processing bodies in ...precursor miRNA, inhibits BDNF ...
14
Noncanonical MicroRNA (miRNA) Biogenesis Gives Rise to Retroviral Mimics of Lymphoproliferative and Immunosuppressive Host miRNAs
... FV miRNA genes in the LTR region may have applications to retroviral vector ...may function as analogs of some host immunosup- pressive or oncogenic ...
9
The miRNA Biogenesis Machinery Modulates Lineage Commitment During αβ T Cell Development
... context-‐dependent function, T cells regulate numerous pathways and processes, from enabling tissue homeostasis and maximal function of the innate immune system to direct elimination of infected cells ...
125
Functional Redundancy of DICER Cofactors TARBP2 and PRKRA During Murine Embryogenesis Does Not Involve miRNA Biogenesis.
... miRNAs function in the proper development of numerous mammalian organs, and disruptions in this small RNA biogenesis pathway can result in congenital birth defects and in extreme cases fetal ...
12
microPrimer: the biogenesis and function of microRNA
... of miRNA targets will be ...of miRNA expression and maturation remains largely unknown, but many laboratories have begun to map where miRNAs are expressed and what factors regulate their ...miRNAs ...
8
Biogenesis and function of extracellular miRNAs
... It has been shown that lipids, proteins and nucleic acids, including miRNAs, can be exchanged by MVs, giving them the ability to target recipient cells [21–25]. The membrane structure of MVs can protect miRNAs from ...
9
Biogenesis, Size and Function of Small RNAs
... from: Khraiwesh et al. 2012 Biochimica et Biophysica Acta 1819:137 Fig. 1. Biogenesis and function of miRNAs and siRNAs. (A) MIR genes are initially transcribed by PolII into a single-stranded RNA that ...
12
Biogenesis and Function of Circular RNAs in Health and in Disease
... sponging function was elegantly demonstrated by Memczak et ...sponging function of a circRNA CDR1as or ...its function in an in vitro study using HEK293 cellls ( Hansen et ...
11
Mouse mirna-709 directly regulates mirna-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microrna hierarchy system
... and miRNA function-required argonaute family proteins in the cell nucleus have prompted us to hypothesize that miRNAs may also have regula- tory functions in the cell ...one miRNA can control the ...
12
Regulation of Plant miRNA Biogenesis
... miRNA* duplex of 20-22-nt length by DCL1 with the help of few accessory proteins. It is not known why only one or rarely more than one miRNA results from these long dsRNA precursors. In this review, we ...
15
Computational modeling of mirna Biogenesis
... of miRNA biogeneis, from transcriptional regulation to post-transcriptional ...predicted miRNA promoters from PROmiRNA, a miRNA promoter prediction tool, can be used to identify the most probable ...
13
Plant peroxisomes: biogenesis and function
... contributions from the Arabidopsis Peroxisome 2010 project (www.peroxisome.msu.edu; for review see (Kaur et al., 2009; Kaur and Hu, 2011; Reumann, 2011). Protein identification by experimental proteomics is only the ...
67
Hypoxia Mediated Downregulation of miRNA Biogenesis Promotes Tumor Progression
... . miRNA or siRNA for in vivo intratumour delivery was incorporated into DOPC, as previously described 43 ...injection. miRNA microarray and deep sequencing ...using miRNA microarray (Agilent ...
13
Alternative use of miRNA biogenesis co factors in plants at low temperatures
... as miRNA processing have to be adjusted to fluctuating environmental ...plant miRNA biogenesis machinery becomes more robust, producing miRNAs even in the absence of the key DCL1 co-factors HYL1 and ...
7
A Baculovirus-Encoded MicroRNA (miRNA) Suppresses Its Host miRNA Biogenesis by Regulating the Exportin-5 Cofactor Ran
... an miRNA (bmnpv-miR-1) that downregulates the expression of the host GTP- binding nuclear protein Ran, an essential component of the exportin-5-mediated nucleocytoplasmic transport machinery mainly involved in ...
13
miRNA-221 and miRNA-222 synergistically function to promote vascular calcification
... Through the transfection of calcifying VSMCs with mimics of these miRs, we show that there are no signi fi cant changes in Runx2 and Msx2 expressions between different miR treat- ments. These data indicate that the ...
8
mirna Regulons Associated with Synaptic Function
... one miRNA binding site with, approximately, half being targeted by more than five ...that miRNA regulation is widespread among synaptic proteins and that multiple miRNAs ensure tight control of synaptic ...
14