mitochondria permeability transition pore
Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease
... There is evidence that pathological cytosolic calcium in- crease can activate the mitochondrial permeability tran- sition pore (mPTP) [30]. In general, the opening of mPTP has been associated with the ...
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Modulation of Mitochondrial Permeability Transition Pore Affects Multidrug Resistance in Human Hepatocellular Carcinoma Cells
... dithiothreitol, 0.1 mM phenylmethylsulfonyl fluoride, and 10 μg/ml each leupeptin, aprotinin, and pepsta- tin A) containing 250 mM sucrose. To lyse the cells, cell suspension was passed five times through a 26-gauge ...
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Influence of Tl(+) on the Ca(2+) and Na(+) movement across rat neonatal cardiomyocytes and rat heart mitochondria membranes
... mitochondrial permeability transition pore (MPTP) in the inner membrane ...liver mitochondria in medium with TlNO 3 , 125 mM nitrates (KNO 3 , NH 4 NO 3 , NaNO 3 ) and 100 μM Ca ...
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a-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
... PTP opening in mitochondria can be triggered by two major stimuli, calcium and reactive oxygen species (ROS). First we tested whether a physiological calcium stimulus, low concentra- tion of glutamate (1 μM), ...
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Ubisol-Q10 Prevents Glutamate-Induced Cell Death by Blocking Mitochondrial Fragmentation and Permeability Transition Pore Opening
... HT22 cells were grown on Lab-Tek II Chamber Slide (Thermoscientific). Mitochondrial staining was carried out with MitoTracker®Red CM-XRos (Invitrogen) as described previously [5]. DAPI was used to label nuclei. Minimum 3 ...
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The membrane permeability transition in liver mitochondria of the great green goby Zosterisessor ophiocephalus (Pallas)
... MPT pore opening in non-mammalian organisms (Szabò et ...‘giant mitochondria’ could be utilized as a marker for monitoring cell damage by environmental ...liver mitochondria isolated from the teleost ...
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Effect of Fish and Flaxseed Oil Supplementation on Isoprenaline-Induced Myocardial Infarction in Rats: Inhibition of Mitochondrial Permeability Transition Pore Opening
... Materials and Methods: The study was conducted on 40 male Wistar rats which were included in control, ISO, FO + ISO, and FLO + ISO groups (each containing 10 rats). In ISO rats, acute myocardial ischemia was induced by ...
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Mitochondria in energy limited states: mechanisms that blunt the signaling of cell death
... the permeability transition pore, to assemble additional protein release channels, and to release pro-apoptotic ...of mitochondria-based pathways for the signaling of apoptotic and necrotic ...
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<p>Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening</p>
... The change of ΔΨ m was detected by using Mitochondrial Membrane Potential Assay Kit with JC-1 (Beyotime Institute of Biotechnology, Shanghai, China) according to the manufacturer ’ s protocol. To be speci fi c, JC-1 is an ...
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Anoxia mediated calcium release through the mitochondrial permeability transition pore silences NMDA receptor currents in turtle neurons
... mitochondrial pore formation is intracellular/matrix pH, as isolated mitochondria exposed to solutions of pH ...mitochondrial permeability of those exposed to pH ...mitochondrial permeability ...
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Glycogen synthase kinase 3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore
... cellular mitochondria by the local photoproduction of ROS (by laser photoexcitation of a precise area within a cell loaded with TMRM) causes approximately two-thirds of the population of cells exposed in this ...
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Vaccinia Virus Infection Disarms the Mitochondrion-Mediated Pathway of the Apoptotic Cascade by Modulating the Permeability Transition Pore
... infection. Mitochondria were purified and incubated at 37°C with 5, 10, or 15 mM atractyloside ...into mitochondria-containing and soluble fractions, and translocation of cytochrome c was analyzed by ...
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Regulation of mitochondrial permeability transition pore by PINK1
... intact mitochondria in PINK1 − / − cells recapitulate the respiratory defect in isolated mitochondria from PINK1 − / − mouse brains, suggesting that these PINK1 − / − cells are a valid experimental system ...
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Protective effects of potassium transport in mitochondria from rat myometrium under activation of mitochondrial permeability transition pore
... M itochondria play an important role in regulation of cell life and death as they are involved in realization of the most important functions, such as providing of energy substrates and control over cell death [1]. The ...
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ACTIVITY OF APIGENIN AND QUERCETIN ON RAT HEPATIC MITOCHONDRIAL PERMEABILITY TRANSITION PORE
... the mitochondria. The brown mitochondria pellet obtained after the supernatant was discarded, was washed and re-suspended in sucrose and re- centrifuged at 12000rpm (9000g) for 10 ...
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The influence of ATP-dependent K(+)-channel diazoxide opener on the opening of mitochondrial permeability transition pore in rat liver mitochondria
... Возврат Са 2+ в матрикс после перевода поры в закрытое со- стояние с помощью циклоспорина А также по- казывает, что при открывании поры происхо- дит активация циклического транспорта С[r] ...
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The effect of permeability transition pore opening on reactive oxygen species production in rat brain mitochondria
... Fig. 1. The influence of membrane potential on the rate of rOS formation in the rat brain mitochondria. A: Dependence of membrane potential (1) and the rates of oxygen consumption (2) and rOS formation (3) on the ...
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Increased susceptibility of striatal mitochondria to calcium-induced permeability transition
... of mitochondria from cortex, hip- pocampus, and cerebellum did not vary and thus could not ex- plain differences in susceptibility to the mPT among these brain regions (Friberg et ...striatal mitochondria ...
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The effects of compression on single and multiphase flow in a model polymer electrolyte membrane fuel cell gas diffusion layer
... of permeability and partly to observe the effects on the flow to enable comparisons with the multiphase ...of pore and throat sizes but can be thought of as representing the average properties of the ...
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Studying Pore Structure of Nonwovens with 3D Imaging and Modeling Permeability.
... As seen in Chapter 4, taking 2D images from continuous layers of a nonwoven media through DVI or micro CT and transferring the images to Avizo ® , after applying any required image pre-processings, results in obtaining ...
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