mitochondrial damage
The mechanism underlying acetaminophen induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation
... when mitochondrial dam- age is involved, not just cell ...cell damage caused by furosemide, a hepatotoxicant not believed to affect mitochondria (43), resulted in ALT release, but not a statistically ...
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Airborne Particulate Matter and Mitochondrial Damage: A Cross-Sectional Study
... for damage and meet the increased respiratory demand required for ROS clearance ...oxidative damage to mitochondria and other intracellular constituents including DNA, RNA, proteins, and lipids ...[23]. ...
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Tumor-suppressive function of SIRT4 in neuroblastoma through mitochondrial damage
... Methods: Expression of SIRT4 in 158 pairs of human NB tumor tissues and adjacent normal tissues collected from March 2009 to October 2012 was analyzed by immunohistochemistry, Western blotting, and real-time fluorescence ...
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Silica nanoparticle-induced oxidative stress and mitochondrial damage is followed by activation of intrinsic apoptosis pathway in glioblastoma cells
... detected in other gene transcripts (Figure 5G). However, after 48-hour SiNP treatment, a shift toward a proapoptotic transcriptional profile was observed, with significant up- regulation of BAX, PUMA, and NOXA, ...
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Hepatic Mitochondrial Damage Aggravated By Azathioprine: Protective Effect of Quercetin
... attacks the enzyme; leading to its diminished activity thereby stopping the formation of NADH which consequently does not participates in ETC, resulting in depleted ATP levels [30]. ICDH controls he redox balance in ...
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SiO<sub>2</sub> nanoparticle-induced impairment of mitochondrial energy metabolism in hepatocytes directly and through a Kupffer cell-mediated pathway in vitro
... to damage by these ...of mitochondrial energy ...and mitochondrial damage accompanied by decreases in mitochondrial dehydro- genase activity, mitochondrial membrane potential, ...
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RETRACTED ARTICLE: LATS2 overexpression attenuates the therapeutic resistance of liver cancer HepG2 cells to sorafenib-mediated death via inhibiting the AMPK–Mfn2 signaling pathway
... the mitochondrial apoptosis pathway to promote cancer ...to mitochondrial damage, mitochondria themselves would initiate the repair sys- tem to correct excessive mitochondrial injury, which is ...
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Isocitrate Dehydrogenase Is Important for Nitrosative Stress Resistance in Cryptococcus neoformans, but Oxidative Stress Resistance Is Not Dependent on Glucose-6-Phosphate Dehydrogenase
... The opportunistic intracellular fungal pathogen Cryptococcus neoformans depends on many antioxidant and denitrosylating proteins and pathways for virulence in the immunocompromised host. These include the glutathione and ...
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Metabolic memory in mitochondrial oxidative damage triggers diabetic retinopathy
... of mitochondrial electron transport chain complex in retinal cells and effectively promote the pro- duction of ROS and suppress the activation of NF-κB and TGF-β signaling pathways, suggesting that ...
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Astragalus polysaccharides suppresses high glucose-induced metabolic memory in retinal pigment epithelial cells through inhibiting mitochondrial dysfunction-induced apoptosis by regulating miR-195
... and mitochondrial dysfunction lead to the cell apoptosis which finally causes the blindness (Kowluru ...the mitochondrial damage-induced cell apoptosis caused by the HG ...the damage of ...
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Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission
... FA mitochondrial damage? To answer that part, a cybrid technology can be applied ...DNA damage and repair machinery share common clinical phenotypes with mitochondria-related disorders ...
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Molecular Mechanisms of Cardiotoxicity: A Review on Major Side-effect of Doxorubicin
... doxorubicin-induced damage to mitochondria likely triggered respiratory chain defect at first that permitted continuous production of free radicals and mitochondrial damage, which might have led to ...
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Bax inhibitor 1 preserves mitochondrial homeostasis in acute kidney injury through promoting mitochondrial retention of PHB2
... for mitochondrial apoptosis ...between mitochondrial PHB2 import and ...PHB2 mitochondrial import may be considered a physiological process whereas the PHB2 “escape” from mitochondria could be ...
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A Novel Role of Exogenous Carbon Monoxide on Protecting Cardiac Function and Improving Survival against Sepsis via Mitochondrial Energetic Metabolism Pathway
... with mitochondrial energetic ...of mitochondrial number, effectively inhibited cardiac mitochondrial damage in septic mice by modulating glucose uptake, adenosine triphosphate and lactate ...
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Overview The Role Of Reactive Oxygen Species In Pathogenesis Of Neurodegenerative Disease
... of mitochondrial electron transport chain has also been associated with the pathophysiology of AD ...in mitochondrial electron transport enzymes in AD is a deficiency in cytochrome c oxidase [26, 27], which ...
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Biofactors in food promote health by enhancing mitochondrial function
... Hydroxytyrosol is thought to be protective because it has the ability to increase PGC-1α and improve mitochon- drial and cellular ROS-related func- tions. In cultured adipocytes (fat cells), hydroxytyrosol increases both ...
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Defects Associated with Mitochondrial DNA Damage Can Be Mitigated by Increased Vacuolar pH in Saccharomyces cerevisiae
... the mitochondrial genome prevents oxidative phosphorylation, yet there are additional biochemical con- sequences of mtDNA ...mutation. Damage to mtDNA perturbs the tricarboxylic acid cycle, a major hub for ...
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Repetitive transcranial magnetic stimulation reduces remote apoptotic cell death and inflammation after focal brain injury
... from the site of damage. Although the efficacy of rTMS in reducing apoptotic cell death in our model is quite specific, further mechanistic studies are required to identify signaling pathways of rTMS effects on ...
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Clinical review: Oxygen as a signaling molecule
... Nrf2-dependent genes are critical for the maintenance of cellular redox homeostasis. Th is transcription factor is constitutively expressed in the cytoplasm and is regulated by ubiquitinylation under the dynamic control ...
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THE HUNTING OF THE SHREW
... THE SECRET OF SHUNTING? The primary role of the vertebrate cardiorespiratory system is to deliver oxygen to tissues and transport carbon dioxide and other wastes of metabolism to the body’s excretion sites (i.e. the ...
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