mitochondrial fission
The Effect of Mangiferin on Improving Endothelial Dysfunction by Inhibiting Endoplasmic Reticulum Stress to Alleviate Mitochondrial Fission
... cytoplasm. Mitochondrial Ca 2+ overload induced ROS generation in mitochondria, and then ROS increased mitochondria fission which released the apoptosis factor thereby triggering the apoptosis program of ...
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Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice
... in mitochondrial fission in vivo and assessed the functional consequences of targeted elimination of the Drp1S600 phosphorylation site in the progression of diabetic nephropathy ...reduced ...
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Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission
... levels. Mitochondrial morphology is regulated by continuous fusion and fission events and the misbalance between these two is often accompanied by ...Moreover, mitochondrial fission ...
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Porcine reproductive and respiratory syndrome virus triggers mitochondrial fission and mitophagy to attenuate apoptosis
... The mitochondrial dynamics and mitophagy play crucial roles in metabolism, cellular differentiation and neurodegeneration [28, ...of mitochondrial dynamics and mitophagy were broadly studied in the context ...
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Mitochondrial Fission Induces Glycolytic Reprogramming in Cancer-Associated Myofibroblasts, Driving Stromal Lactate Production, and Early Tumor Growth
... Here, we used a genetic approach to stringently test this energy-transfer hypothesis. First, we generated hTERT-immortalized fibroblasts which were genetically re-programmed towards catabolic metabolism. Metabolic ...
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Mitochondrial fission and fusion in Dictyostelium discoideum: a search for proteins involved in membrane dynamics
... in mitochondrial fission or fusion There are numerous proteins, based on function or homology, which may play a role in mitochondrial fis- sion or ...[32]. Mitochondrial morphology of midA - ...
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Peroxisome derived lipids regulate adipose thermogenesis by mediating cold induced mitochondrial fission
... impaired mitochondrial fission, as observed with genetic inactivation of Drp1 ...The mitochondrial morphology was quantified by visual inspection of cells to determine the ...
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Crosstalk between Mitochondrial Fission and Oxidative Stress in Paraquat-Induced Apoptosis in Mouse Alveolar Type II Cells
... cells, mitochondrial fusion is controlled by mitochondria-shaping proteins, including the large GTPase mitofusins2 (Mfn2) and optic atrophy protein 1 (OPA1) [13], whereas the mitochondrial fission 1 ...
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TNFα promotes glioblastoma A172 cell mitochondrial apoptosis via augmenting mitochondrial fission and repression of MAPK–ERK–YAP signaling pathways
... B) Mitochondrial potential was observed via JC-1 ...normal mitochondrial potential, whereas green fluorescence of the JC-1 probe means a defective mitochondrial ...for mitochondrial ...
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RETRACTED ARTICLE: IL-2 augments the sorafenib-induced apoptosis in liver cancer by promoting mitochondrial fission and activating the JNK/TAZ pathway
... that mitochondrial fission could be controlled by TAZ through the regulation of mitochondrial lipid syn- thesis ...through mitochondrial fission ...promote mitochondrial ...
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Dynamin-Related Protein 1-Dependent Mitochondrial Fission Changes in the Dorsal Vagal Complex Regulate Insulin Action
... in mitochondrial dynamics alter insulin action and glucose homeostasis remains ...in mitochondrial fission in par- allel to an activation of dynamin-related protein 1 (Drp1) in the dorsal vagal ...
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Mitochondrial fission as a driver of stemness in tumor cells : mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling
... require mitochondrial elongation and trafficking to the periphery of the ...link mitochondrial localisation and cell motility by describing a redistribution of mitochondria toward the leading edge of cells ...
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Mitochondrial fission/fusion dynamics and apoptosis
... promotes fission by tethering to mitochondria at specific positions known as constriction ...constricting mitochondrial tubules leading to mitochondrial fission (Smirnova et ...mediating ...
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ROS-mediated activation and mitochondrial translocation of CaMKII contributes to Drp1-dependent mitochondrial fission and apoptosis in triple-negative breast cancer cells by isorhamnetin and chloroquine
... of mitochondrial fission, and its recruitment to mitochon- dria is tightly regulated by posttranslational modifica- tions such as phosphorylation, S-nitrosylation, SUMOylation, and ubiquitination ...
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Berberine Protects Glomerular Podocytes via Inhibiting Drp1-Mediated Mitochondrial Fission and Dysfunction
... on mitochondrial biology have proposed that excessive mitochondrial fission and mitochondrial dysfunction in podocytes are typical features of kidney injury, but preceding the clinical ...
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Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis
... erucin-mediated mitochondrial fission during ...of mitochondrial fission [26, ...mediates mitochondrial fission ...the mitochondrial tubule ...and mitochondrial ...
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Endothelin-1 induces LIMK2-mediated programmed necrotic neuronal death independent of NOS activity
... of mitochondrial fission at 3 days after ...of mitochondrial length in the CA1 neurons ( n = 10 per each ...increases mitochondrial length and sphere ...alleviate mitochondrial ...
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Original Article The role of mitochondrial quality control in lumbar spinal cords of SOD1-G93A transgenic mice
... (MNs). Mitochondrial dysfunction plays an important role in ALS and it is a converg- ing point of multiple pathological pathways in ...The mitochondrial quality control including mitochondrial ...
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Orgler, Christina (2019): The potential to identify and explore innovative anticancer targets by using the natural products Vioprolide A and Lagunamide A. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... targeting mitochondrial dynamics Mitochondria are extremely dynamic organelles that constantly fuse and ...the mitochondrial network undergoes moderate fission and fusion, in order to fill the ...
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Emerging role for members of the Bcl 2 family in mitochondrial morphogenesis
... of mitochondrial dynamics, how does this operate at a molecular level? This is where confusion currently reigns, because interac- tions have been reported between several Bcl-2 family proteins, both pro- and ...
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