Mitochondrial metabolism
NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation
... to mitochondrial DNA (mtDNA), and mtDNA-encoded respira- tory chain components are upregulated in the manner dependent on ...and mitochondrial respiration lead to enhanced mitochondrial oxidative ...
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SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis
... two mitochondrial sirtuins function as sensing, watchdog, or TS proteins in vitro, in vivo, and in human tumor ...the mitochondrial anti-aging or fidelity/sensing proteins, SIRT3 and SIRT4, respond to ...
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Defects in mitochondrial metabolism and cancer
... the mitochondrial (IDH2) NADPH-dependent isoforms have been found in vari- ous human cancers, including colon cancer [22], glio- blastoma [23], glioma [24], acute myeloid leukemia [25], prostate cancer [26], ...
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Mitochondrial metabolism in pulmonary hypertension: beyond mountains there are mountains
... that mitochondrial changes may provide context for these spatiotemporal ...p53, mitochondrial biogenesis gene expression, and gly- colytic flux, resulting in a proinflammatory state that predisposes to ...
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Synthesis and evaluation of frentizole based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer’s disease treatment
... Several mitochondrial proteins have been shown to interact directly with Aβ, possibly influencing mitochondrial ...and mitochondrial and synaptic ...Aβ-induced mitochondrial and neuronal ...
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Mitochondrial energy metabolism in heart failure: a question of balance
... cardiac mitochondrial biogenesis and respiratory function PGC-1α: an inducible integrator of transcriptional circuits regulating mito- chondrial biogenesis and ...regulating mitochondrial metabolism ...
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Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death
... defective mitochondrial bioenergetics [12, ...the mitochondrial polymorphisms found in C13 cells are not causative of the different mitochondrial asset previously ...C13 mitochondrial ...
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Hypothesis of Opposite Interplay Between the Canonical WNT/beta-catenin Pathway and PPAR Gamma in Primary Central Nervous System Lymphomas
... PCNSLs are angiocentric neoplasia which are infiltrative and extend beyond the primary lesion. ABC-DLBCL subtype represents more than 90% of PCNSLs and is the most aggressive subtype with a cure rate of only 40%. ...
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Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms
... energy metabolism, and heart mitochondria process the highest amount of oxygen to meet the energy requirments for the proper functioning of the ...Therefore, mitochondrial dysfunction can play an important ...
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Effects of carnitine on oxidative stress response to intravenous iron administration to patients with CKD: impact of haptoglobin phenotype
... kidney disease [49]. In the last decade there are increasing reports describing the beneficial use of carnitine for a bet- ter energy metabolism (mitochondrial metabolism). In this context Carnitine ...
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Transcriptome analysis of mRNA and miRNA in skeletal muscle indicates an important network for differential Residual Feed Intake in pigs
... to metabolism, particularly energy and lipid metabolism, as well as biosynthetic processes and muscle cell growth and ...energy metabolism were down-regulated, whereas quite a few miRNAs that target ...
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Series Introduction: The expanding network of redox signaling: new observations, complexities, and perspectives
... oxidative metabolism is central to the biology and health of all humans, how we respond to conditions of low and high oxygen stress has become a critical consideration in biology and ...to mitochondrial ...
5
Mitochondria in lung disease
... toms. Mitochondrial dysfunction is rapidly advancing as a key patho- logical feature that appears early and consistently in the development of lung ...abnormal mitochondrial signatures, including metabolic ...
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PPARs modulate cardiac metabolism and mitochondrial function in diabetes
... acid metabolism [13, ...glucose metabolism and are thus likely to be impacted by metabolic derange- ments in ...Proper mitochondrial function is critical for maintaining optimal cardiac ...
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Original Article Effects of PPARα/PGC-1α on the energy metabolism remodeling and apoptosis in the doxorubicin induced mice cardiomyocytes in vitro
... substrate metabolism were ...group. Mitochondrial dysfunction was found in doxorubicin group including lower content of high-energy phosphates, significantly decreased mitochondrial ANT transport ...
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Sawyeria marylandensis (Heterolobosea) Has a Hydrogenosome with Novel Metabolic Properties
... N-terminal mitochondrial/hydrogenosomal targeting pep- tide (HydE is a partial sequence) in Sawyeria marylandensis suggests this organism truly possesses ...
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In silico experimentation with a model of hepatic mitochondrial folate metabolism
... folate metabolism allows one to conduct in silico experiments to test ideas and hypotheses about how the system as a whole ...the mitochondrial model in this paper show that its behavior is consistent with ...
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Recreating Bioenergetic Elements In Protein Maquettes
... Physiological ET reactions involving mitochondrial cyt c extend beyond the protein complexes of the ETC. In yeast, cyt c supports peroxide reduction by providing electrons to cytochrome c peroxidase. Cyt c release ...
158
Brain mitochondrial bioenergetics change with rapid and prolonged shifts in aggression in the honey bee, Apis mellifera
... brain mitochondrial activity as bees age, we compared ‘ old ’ adult worker bees with ‘ young ’ adult worker bees collected from the same ...brain mitochondrial respiration for bees that show strong ...
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Cold and Heat Stress Diversely Alters Both Cauliflower Respiration and Distinct Mitochondrial Proteins Including OXPHOS Components and Matrix Enzymes
... appeared that the majority of cauliflower mitochondrial protein spots responsive to cold and heat 211.. stress, belonged to the class participating in carbohydrate metabolism, including[r] ...
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