Mitochondrial morphology
Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice
... the mitochondrial network through mitochondrial fission ...increase mitochondrial length and branching complexity ...processes, mitochondrial dynamics and morphology transitions also ...
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Heterogeneity in Mitochondrial Morphology and Membrane Potential Is Independent of the Nuclear Division Cycle in Multinucleate Fungal Cells
... in morphology and membrane potential and therefore can serve as a reporter of the cell cycle state of the ...local mitochondrial morphology and membrane potential in ...both morphology and ...
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Maintenance of Mitochondrial Morphology in Cryptococcus neoformans Is Critical for Stress Resistance and Virulence
... However, mitochondrial fusion beyond WT levels (in the context of FZO1 overexpression or defects in fission) did not promote cell survival in either of these ...enhanced mitochondrial fusion leads to defects ...
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Neither respiration nor cytochrome c oxidase affects mitochondrial morphology in Saccharomyces cerevisiae
... that mitochondrial morphology can be affected by cellular energy metabolism (see Bereiter-Hahn and Voth, ...the mitochondrial volume in non-repressed cells accounts for up to 12 % of the cell volume, ...
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Maintenance of Mitochondrial Morphology Is Linked to Maintenance of the Mitochondrial Genome in Saccharomyces cerevisiae
... of mitochondrial DNA migration to the nucleus, carbon-source-dependent alterations in mitochondrial morphology, and increased rates of mitochondrial DNA ...requiring mitochondrial ...
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Two Dictyostelium Orthologs of the Prokaryotic Cell Division Protein FtsZ Localize to Mitochondria and Are Required for the Maintenance of Normal Mitochondrial Morphology
... work together in some organisms. C. merolae not only pro- duces FtsZs that are targeted to the interior of its mitochon- drion (46, 62) and plastid (41, 43, 44) but also contains two dynamins. The first, CmDnm1, is ...
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Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells
... regulate mitochondrial dynamics in mammalian cells (43, 44), to our knowledge no F-box protein has been previously reported to target MFN for ubiquitylation and ...triggered mitochondrial fission-to-fusion ...
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Lipopolysaccharide-induced alteration of mitochondrial morphology induces a metabolic shift in microglia modulating the inflammatory response in vitro and in vivo
... Real-time measurements of oxygen consumption rates (OCRs) and extracellular acidification rates (ECARs), a measure of lactate produc- tion, were performed on an XFe96 Seahorse extracellular flux analyser (Seahorse ...
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The control of mitochondrial morphology and dynamics in Arabidopis thaliana
... cerevisiae CluA homologue, Clul p 20%identical, 34% similar to the Arabidopsis protein; 24% identical, 39% similar to CluA has also been shown to be involved in the maintenance of normal[r] ...
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Rab32 connects ER stress to mitochondrial defects in multiple sclerosis
... and mitochondrial dysfunction, our observation that ER stress leads to Rab32 induction and subse- quently alters mitochondrial dynamic as well as neuronal apoptosis induction identifies Rab32 as a protein ...
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The Role of Mitofusin Proteins in Mitochondrial Fusion and Disease
... alter mitochondrial morphology, expression knock-down approaches are amenable to identifying putative fusion ...identifying morphology factors, as visual screens of knock-out yeast libraries have ...
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Bot1p Is Required for Mitochondrial Translation, Respiratory Function, and Normal Cell Morphology in the Fission Yeast Schizosaccharomyces pombe
... some mitochondrial proteins are essential for mtDNA stability ...disrupt mitochondrial structure and function. (A) Mitochondrial morphology and ...of mitochondrial gene ...
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A γ-Secretase Independent Role for Presenilin in Calcium Homeostasis Impacts Mitochondrial Function and Morphology in Caenorhabditis elegans
... to mitochondrial morphology defects as observed in SEL-12-deficient ...impacting mitochondrial function is independent of g-secretase ...the mitochondrial defects that we observe in ...
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Quantitative Proteomics Analysis Identifies Mitochondria as Therapeutic Targets of Multidrug-Resistance in Ovarian Cancer
... compare mitochondrial protein expression in doxorubicin sensitive OVCAR8 cells and its doxorubicin-resistant variant NCI_ADR/RES ...a mitochondrial protein participated in DNA repair, was involved in ...
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A novel mutation in SPART gene causes a severe neurodevelopmental delay due to mitochondrial dysfunction with Complex I impairments and altered pyruvate metabolism
... n=35 live cells measured for each cell line using ImageJ Mitochondrial Morphology plugin.... OXPHOS complex activity measurements.[r] ...
66
Deleted in cancer 1 (DICE1) is an essential protein controlling the topology of the inner mitochondrial membrane in C elegans
... In summary, the DICE1 homolog in C. elegans is essential for normal mitochondrial morphology and function, and its deficiency induces apoptosis and inhibits development at a number of stages. The major ...
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Regulation of mitochondrial dynamics in adipose tissue
... functional mitochondrial DNA is retained whilst com- promised mitochondrial DNA is selectively eliminated (Ren, Pulakat et ...conditions, mitochondrial biogenesis is impaired thereby contribut- ing ...
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Bezafibrate improves mitochondrial fission and function in DNM1L deficient patient cells Liza Douiev 1*, Ruth Sheffer1 , Gabriella Horvath 2, Ann Saada 1,3
... [10] mitochondrial morphology in patient fibroblasts is aberrant with markedly elongated mitochondria compared to normal fibroblasts grown under the same conditions ...on mitochondrial ...
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Original Article Mitochondrial biogenesis in ventral spinal cord and nerve following sciatic nerve axotomy
... whether mitochondrial biogenesis is involved in post-injury nerve degradation and regeneration ...that mitochondrial biogenesis was down-regulated in spinal cord and up-regulated in proximal nerve after ...
8
Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK
... For Western blot analysis of phospho (p)-p47phox, p- ERK, p-p38, p-JNK, Iba-1, cleaved caspase 3, and TH, striatal tissues were lysed in buffer containing a 200 mM Tris–HCl (pH 6.8), 1 % SDS, 5 mM EGTA, 5 mM EDTA, 10 % ...
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