Mitochondrial respiratory chain complexes
Coenzyme Q10 defects may be associated with a deficiency of Q10-independent mitochondrial respiratory chain complexes
... of mitochondrial respiratory chain activity, increased mitochondrial oxidative stress and reversal of ATP synthase activity: implications for pathogenesis and ...
9
Studies on the genetics and molecular pathogenesis of mitochondrial respiratory chain disorders
... Five mitochondrial respiratory chain complexes lying in the inner mitochondrial membrane are responsible for energy production by oxidative phosphorylation [Cooper and Clark ...of ...
161
Lysine Restriction and Pyridoxal Phosphate Administration in a NADK2 Patient
... of mitochondrial respiratory chain complexes III and IV was slightly low in muscle, other cofactors such as ubidecarenone, idebenone, vitamin E, and creatine were added to the ...
8
Mitochondrial function in diaphragm of emphysematous hamsters after treatment with nandrolone
... preventing respiratory failure only in patients receiving ...of mitochondrial respiratory chain complexes in the diaphragm in both normal and emphysematous hamsters was equal, and that ...
8
Pioglitazone leads to an inactivation and disassembly of complex I of the mitochondrial respiratory chain
... Our study shows that PGZ affects the stability of complex I as indicated by the presence of its subunits in the mature holoenzyme and four additional lower molecular weight subcomplexes with apparent molecular masses of ...
15
Mitochondrial genome variability: the effect on cellular functional activity
... the respiratory chain complexes I and II, ...re-oxidized. Respiratory chain complex III reduces cytochrome c, which in turn transfers the electrons to complex IV, where oxygen is ...
9
Decoding Warburg’s hypothesis: tumor-related mutations in the mitochondrial respiratory chain
... in mitochondrial membrane potential, which leads to the dysfunction of the entire organelle [26, 31, 32, ...the complexes exhibit reduced expression from both nDNA or mtDNA [85, ...the mitochondrial ...
18
Ubiquinone reacts with nitric oxide to prevent the activity of purified complex 1
... electron-transport chain involved in cellular respiration and photosynthesis [Nohl et ...from complexes I and II to complex in and the translocation of protons in the mitochondrial respiratory ...
138
Reduction of apoptosis and preservation of mitochondrial integrity under ischemia/reperfusion injury is mediated by estrogen receptor β
... the mitochondrial inner membrane ...of mitochondrial structure and integrity by activating ER β ...The respiratory chain in the inner mitochondrial membrane is responsible for ...
9
Mitochondrial dysfunction in Autism Spectrum Disorders
... of mitochondrial dysfunction in a number of diseases such as Alzheimer’s [8,29] and cancer [27], research groups have regained interest in field of mitochondrial genetics and ...of mitochondrial gene ...
8
Clinical Reasoning: A 58-year-old man with progressive ptosis and walking difficulty
... of respiratory chain function. Respira- tory chain enzyme assay might also reveal decreased activity in single or multiple complexes, or even nor- mal ...tologic mitochondrial ...
6
The mitochondria mediate the induction of NOX1 gene expression by aldosterone in an ATF-1-dependent manner
... the mitochondrial respiratory chain as well as NADPH oxidase ...of complexes I and III respectively, blocked the induction of NOX1 by Ald almost ...the mitochondrial respiratory ...
10
Mitochondrial dysfunction in some triple negative breast cancer cell lines: role of mTOR pathway and therapeutic potential
... the mitochondrial respiratory chain activity in four differ- ent cell lines, two triple-negative lines (MAD231 and MDA468) and two receptor-positive lines (BT474 and MCF7), showed that TNBC cells ...
16
Complex I and energy thresholds in the brain
... transport chain complexes, their supramolecular organization into ‘ respirasomes ’ is relatively an under-studied ...these complexes are functionally active even when isolated as individual ...
6
Involvement of an Alternative Oxidase in Oxidative Stress and Mycelium-to-Yeast Differentiation in Paracoccidioides brasiliensis
... and mitochondrial isolation were performed according to the method of Magnani et ...for mitochondrial isolation using an Elvehjem- Potter homogenizer with the addition of a protease inhibitor cocktail ...
12
De novo CTBP1 variant is associated with decreased mitochondrial respiratory chain activities
... Whole-exome sequencing, analysis, and interpretation. Exome capture was attained using the Illumina TruSeq 62 Mb capture kit, sequenced using the Illumina HiSeq 2000 system in 100 base pair (bp) reads, and aligned to the ...
6
Platelet mitochondrial dysfunction in critically ill patients: comparison between sepsis and cardiogenic shock
... platelet mitochondrial physiology, such as oxygen consumption or membrane potential, were not ...Platelet mitochondrial density was evaluated in terms of citrate synthase activity (normal even in critically ...
8
Myocardial Layer Specific Strain Analysis in Children with Mitochondrial Disease
... Many questions still remain to be answered, however. The reason why CMP is the most common form of cardiac involve- ment in MD may be due to the close relationship between myocardial function and mitochondrial ...
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EFFECT OF HONEY BEE AND COQ10 SUPPLEMENTED TO CRYOPRESERVATION SOLUTION ON FREEZE THAWED HUMAN SPERM PARAMETERS
... damage in human spermatozoa, mitochondrial enzymatic activities were shown to be correlated with spermatozoal motility. [29, 30] In present study results showed significant increased (P<0.05) in the percentage ...
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Preserved endothelium-dependent dilatation of the coronary microvasculature at the early phase of diabetes mellitus despite the increased oxidative stress and depressed cardiac mechanical function ex vivo
... Animal weight, heart dry weight, glycemia, activity of respiratory chain complexes, aconitase-to-fumarase and lactate-to-pyruvate ratios and data describing the oxidative stress and the [r] ...
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