Mitochondrial transcription
Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation
... a mitochondrial transcriptional program that enhanced hepatic ...increased mitochondrial transcription and OXPHOS in ...of mitochondrial transcription and OXPHOS by the KR mutant ...
18
Protein sliding and DNA denaturation are essential for DNA organization by human mitochondrial transcription factor A
... The mitochondrial transcription factor A (TFAm), a protein that regulates mitochondrial transcription, is abundant in these ...for mitochondrial DnA compaction, yet the exact mechanism ...
9
p53 increase mitochondrial copy number via up-regulation of mitochondrial transcription factor A in colorectal cancer
... In colorectal cancer, no study has been carried out discovering the relationship among p53, mitochondrial transcription factor A (TFAM) expression and change of mitochondrial DNA (mtDNA) copy number. ...
15
Human Mitochondrial Transcription Factor A Reduction and Mitochondrial Dysfunction in Hashimoto’s Hypothyroid Myopathy
... Human mitochondrial transcription factor A (h-mtTFA) is a nuclear encoded polypeptide with high regulatory effects on both replication and transcription of mito- chondrial DNA (mtDNA) ...mary ...
8
Human Cytomegalovirus Infection Upregulates the Mitochondrial Transcription and Translation Machineries
... of mitochondrial biogene- sis have been identified (reviewed in reference 76), to our knowl- edge, there is no transcription factor yet known to specifically regulate the genes encoding mitochondrial ...
18
Regulation of energy metabolism during early mammalian development: TEAD4 controls mitochondrial transcription
... of mitochondrial regulation and energy metabolism in trophoblast cells is extremely ...of mitochondrial energy ...that mitochondrial dysfunction in trophoblast cells is associated with ...
15
Hillen, Hauke Sven (2017): Structural basis of human mitochondrial transcription initiation and processive elongation. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... The genetic information of all life on earth is encoded in nucleic acid. With few exceptions, the molecule in which information is stored is deoxyribonucleic acid (DNA). First isolated by Friedrich Miescher in 1869, it ...
123
Principles of Exercise Prescription, and How They Influence Exercise-Induced Changes of Transcription Factors and Other Regulators of Mitochondrial Biogenesis
... induce mitochondrial biogenesis, and it is routinely used to prevent and treat chronic metabolic disorders linked with sub-optimal mitochondrial ...healthy mitochondrial pool, it is vital to better ...
53
Ringel, Eva Rieke (2011): Molecular basis of RNA polymerase III transcription repression by Maf1 & Structure of human mitochondrial RNA polymerase. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... mammalian mitochondrial transcription machineries, based on foot- printing data and functional ...Mammalian mitochondrial transcription critically depends on the presence of TFB2M and TFAM ...
111
Regulation of mitochondrial dynamics in adipose tissue
... functional mitochondrial DNA is retained whilst com- promised mitochondrial DNA is selectively eliminated (Ren, Pulakat et ...conditions, mitochondrial biogenesis is impaired thereby contribut- ing ...
291
Sequence and structural evolution of the KsgA/Dim1 methyltransferase family
... A distinct eukaryotic ortholog, mtTFB, is transported into the mitochondria where, in addition to methylating the small subunit rRNA, it has adopted the ribosomally unre- lated function of serving as a ...
9
Increase of mitochondrial DNA content and transcripts in early bovine embryogenesis associated with upregulation of mtTFA and NRF1 transcription factors
... active transcription of the mitochondrial genome starts at different developmental stages depending on the ...mtDNA transcription occurs in the late 2-cell stage, whereas it occurs in the 4/8-cell ...
8
Mitocans as Novel Agents for Anticancer Therapy: An Overview
... the mitochondrial membrane integrity is lost, a collapse in bioenergetic status, redox equilibrium and ion homeo- stasis takes place leading to cell ...between mitochondrial membrane permeabilization and ...
15
Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK
... For Western blot analysis of phospho (p)-p47phox, p- ERK, p-p38, p-JNK, Iba-1, cleaved caspase 3, and TH, striatal tissues were lysed in buffer containing a 200 mM Tris–HCl (pH 6.8), 1 % SDS, 5 mM EGTA, 5 mM EDTA, 10 % ...
22
Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage
... resolves mitochondrial PDBs (mtPDBs), thereby promoting mitochondrial gene ...of mitochondrial topo- isomerase I (TOP1mt*), which generates excessive mtPDBs, results in a TDP1-dependent compensatory ...
15
Mechanisms Underlying Cisplatin Induced Nephrotoxicity- A Review
... 2.3 Mitochondrial changes in cisplatin nephrotoxicity Varieties of research on cisplatin indicate that mitochondrial DNA, or other mitochondrial targets, could be more important than nuclear DNA ...
5
Controlling muscle mitochondrial content
... The mitochondrial Lon protease is very effective at detecting and degrading mildly damaged aconitase (Bota and Davies, ...optimal mitochondrial function, but they can also be used during periods of active ...
7
Sls1p Is a Membrane-Bound Regulator of Transcription-Coupled Processes Involved in Saccharomyces cerevisiae Mitochondrial Gene Expression
... (A) Mitochondrial petite phenotypes of the following strains (indicated at the bottom) were assessed at 37⬚: GS122, RPO41 wild type; GS129, rpo41-R129D; and RMS5-6, a strain MATERIALS AND METHODS isolated in our ...
8
Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways
... In examining the effect of atfs-1 deletion on the expres- sion of genes involved in known stress response path- ways, we observed a dramatic upregulation of hsp-16.11 and hsp-16.2, two genes involved in the cytosolic un- ...
19
Regulation of muscle mitochondrial design
... Isoform shifting provides a cell with plasticity by allowing it to respond to physiological or developmental cues by producing a protein demonstrating a more appropriate function. Evolutionary processes also give rise to ...
9