mitochondrial transcription factor 1
Original Article Inhibition of microRNA-182 reduces hypoxia/re-oxygenation-induced HL-1 cardiomyocyte apoptosis by targeting the nuclear respiratory factor-1/mitochondrial transcription factor A (NRF-1/mtTFA) pathway
... respiratory factor-1 (NRF-1) is a transcriptional activator of nuclear genes that encode a range of mitochondrial proteins that sensitize cells to ...of mitochondrial ...
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Human Cytomegalovirus Infection Upregulates the Mitochondrial Transcription and Translation Machineries
... regulatory factor 3 (IRF3) pathway, was also ...virus 1 (HSV1) infection ...scramblase 1, a restriction factor of hepatitis B virus (41), was shown to augment the IFN response by increasing ...
18
Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site
... hyperglycemia-induced mitochondrial superoxide overproduction increases O- linked N-acetylglucosamine modification and decreases O-linked phosphorylation of the transcription factor Sp1, the effect ...
9
Aberrant Nucleo-cytoplasmic Cross-Talk Results in Donor Cell mtDNA Persistence in Cloned Embryos
... oocyte mitochondrial DNA persisting through to blastocyst and being transmitted to the ...dilution factor or directly related to the transcriptional status of the donor cell in respect of ...
13
p53 increase mitochondrial copy number via up-regulation of mitochondrial transcription factor A in colorectal cancer
... incubation was performed with p53 antibody (1:100, Santa Cruz Biotechnology, Santa Cruz, CA, USA) and TFAM antibody (1:100, Abcam, Cambridge, UK) overnight at 4°C, for assessment of p53 and TFAM, ...
15
Protein sliding and DNA denaturation are essential for DNA organization by human mitochondrial transcription factor A
... uman mitochondrial DNA (mtDNA) is a ...the mitochondrial genome can cause profound problems that are linked to a variety of multisys- tem disorders 1 ...
9
Dysfunction of various organelles provokes multiple cell death after quantum dot exposure
... activating transcription factor 4; ATF6, activating transcription factor 6; Bak, Bcl-2 antagonist/killer 1; Bax, Bcl-2-associated X protein; Bcl-2, B-cell lymphoma-2; Bcl-xl, B-cell ...
14
Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways
... In examining the effect of atfs-1 deletion on the expres- sion of genes involved in known stress response path- ways, we observed a dramatic upregulation of hsp-16.11 and hsp-16.2, two genes involved in the ...
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Human Mitochondrial Transcription Factor A Reduction and Mitochondrial Dysfunction in Hashimoto’s Hypothyroid Myopathy
... To evaluate oxidative metabolism in contracting muscle, resting blood lactate concentration and the anaerobic lactate threshold (LT) during isometric in- cremental arm exercise were assessed, as previously described (3), ...
8
Controlling muscle mitochondrial content
... stimulates transcription by acting as a transcriptional ...to transcription factors already bound to DNA at specific recognition sequences, or elements ...of transcription factors from the nuclear ...
7
Protein-protein interactions of transcription factor CREB 1
... coupled transcription- translation from linearized DNA templates with strikingly uniform efficiency between related templates (that is, templates which share common control sequences and are of a similar length), ...
197
The role of osmotic stress transcription factor 1 in fishes
... stress transcription factor 1 (Ostf1) was first discovered by subtractive hybridization in the gills of Mozambique tilapia (Oreochromis mossambicus) transferred from fresh water (FW) to seawater ...
6
Pharmacological inhibition of the transcription factor PU 1 in leukemia
... To gain structural insight into the mechanism by which the diamidines inhibit PU.1 binding to the λB site, we performed a molecular dynamics simulation of the DB2313-λB complex. The λB-bound complex showed the ...
18
Sirtuin 1 Regulates Hepatitis B Virus Transcription and Replication by Targeting Transcription Factor AP-1
... risk factor for liver cirrhosis and hepatocellular ...targeting transcription factor AP-1. The c-Jun subunit of AP-1 was bound to the HBV core promoter region, as demonstrated by using ...
10
Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Factor Requires Cellular Transcription Factor JunD To Upregulate HTLV-1 Antisense Transcription from the 3′ Long Terminal Repeat
... ATF/CREB transcription factors are ubiquitously ex- pressed in mammalian cells (51), the expression of AP-1 tran- scription factors is regulated by the cell activation status (9, 21, ...activate ...
9
A manually curated network of the PML nuclear body interactome reveals an important role for PML-NBs in SUMOylation dynamics
... The dynamic regulation of key point proteins at the PML-NBs supports this hypothesis since the regulatory function of SUMOylation on PML-NB re- lated processes such as transcription [14, 113, 114], cell ...
17
Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF 1α/Jagged2/Notch Axis
... The activation of Notch licenses the tandem cleavage of Notch receptor by metalloprotease and ␥-secretase to release its intracel- lular domain (NICD) that is required for its cellular function (16, 17). We postulated ...
11
Uterine receptivity and implantation: The regulation and action of insulin-like growth factor binding protein-1 (IGFBP-1), HOXA10 and forkhead transcription factor-1 (FOXO-1) in the baboon endometrium
... nuclear transcription factors and cause repression or transactivation of ...nuclear transcription factor which then acts cooperatively to increase the IGFBP-1 promoter activ- ity ...
6
Direct, Interferon-Independent Activation of the CXCL10 Promoter by NF-κB and Interferon Regulatory Factor 3 during Hepatitis C Virus Infection
...  1 construct was also less than that observed during PAMP stimulation, although it remained significantly higher than that observed with the wild- type construct (P ⬍ ...
9
The significance of alternative transcripts for Caenorhabditis elegans transcription factor genes, based on expression pattern analysis
... distinct transcription factor isoforms would be generated if alternative transcripts arose from inclusion versus exclusion of optional introns or ...a transcription factor ...for ...
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