Mitochondrial translation
The mitochondrial translation machinery as a therapeutic target in Myc-driven lymphomas
... a Mitochondrial Ribosomal Protein (MRP) ...the mitochondrial translation apparatus, and in particular other MRP-coding genes, were activated in a concerted manner in lymphomagenesis, extending ...
16
Mitochondrial Translation
... The translation elongation factor EF-Tu is a GTPase that delivers amino-acylated tRNAs to the ribosome during the elongation step of ...both translation factors are found in ...that mitochondrial ...
12
FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders
... primary mitochondrial myopathy, especially in patients with mitochondrial translation defects or mitochondrial DNA (mtDNA) dele- tions (675 and 347 pg/mL, respectively; controls: 66 pg/mL, p , ...
12
Bot1p Is Required for Mitochondrial Translation, Respiratory Function, and Normal Cell Morphology in the Fission Yeast Schizosaccharomyces pombe
... to mitochondrial fragmentation, and to decreased cell respiration, we asked whether Bot1p overexpression would also affect these param- ...the mitochondrial network is not significantly altered ...of ...
11
Complete Repopulation of Mouse Mitochondrial DNA-less Cells With Rat Mitochondrial DNA Restores Mitochondrial Translation but Not Mitochondrial Respiratory Function
... caused mitochondrial dysfunction, even though rat mtDNA could restore normal mitochondrial translation in the ...that mitochondrial respiratory complexes consist of nuclear DNA- and ...
7
Site-directed mutagenesis of a Saccharomyces cerevisiae mitochondrial translation initiation codon.
... Residual translation of the cox3-1 mutant mRNA was dependent upon the three nuclearly coded mRNA-specific activators PET494, PET54 and PET122, known from previous [r] ...
10
Impaired activity of CCA-adding enzyme TRNT1 impacts OXPHOS complexes and cellular respiration in SIFD patient-derived fibroblasts
... in mitochondrial tRNASer (AGY) CCA addition associ- ated with TRNT1 mutation that leads to impairment of mitochondrial translation and decreased abundance in 13 mitochondrial subunits of ...
7
Novel homozygous RARS2 mutation in two siblings without pontocerebellar hypoplasia – further expansion of the phenotypic spectrum
... PCH6 due to mutations in the RARS2 gene is a rare mitochondrial translation defect, and only 29 patients from 15 families have been reported so far, including the 2 patients in this report. Giving an ...
8
Human Cytomegalovirus Infection Upregulates the Mitochondrial Transcription and Translation Machineries
... of mitochondrial biogene- sis have been identified (reviewed in reference 76), to our knowl- edge, there is no transcription factor yet known to specifically regulate the genes encoding mitochondrial ...
18
MrpL36p, a Highly Diverged L31 Ribosomal Protein Homolog With Additional Functional Domains in Saccharomyces cerevisiae Mitochondria
... Many mitochondrial ribosomal components are clearly homologous to eubacterial ribosomal proteins, but others appear unique to the mitochondrial ...of mitochondrial ribosomal proteins appear to be ...
12
AFG3L2 supports mitochondrial protein synthesis and Purkinje cell survival
... inner mitochondrial membrane, exposing the catalytic domains to the matrix (2, ...the mitochondrial ribosomal component MRPL32 ...for mitochondrial translation and the synthesis of ...
12
Highly Diverged Homologs of Saccharomyces cerevisiae Mitochondrial mRNA-Specific Translational Activators Have Orthologous Functions in Other Budding Yeasts
... 1994) are not highly conserved in the other species. The mitochondrially coded targets of the mRNA-spe- lational activation system uncovered in S. cerevisiae may cific translational activators in the COX2 and COX3 be ...
14
Divergence of Erv1-Associated Mitochondrial Import and Export Pathways in Trypanosomes and Anaerobic Protists
... cerevisiae, mitochondrial swelling is seen in a variety of mutants defective in mitochondrial protein import, including Erv1-deficient yeast (42, ...of mitochondrial and cytosolic Fe-S cluster ...
13
Regulation of muscle mitochondrial design
... of mitochondrial proteins in vertebrates in response to physiological signals, other than those occurring during differentiation and development (Stepien et ...
9
The Design of the SauLTC application for the English Arabic Learner Translation Corpus
... the translation genres and the ...draft translation, and final translation with the translation learner ...the translation and how the student modifies the final version compared to the ...
9
Mitochondrial disorders: aetiologies, models systems, and candidate therapies
... demonstrated mitochondrial dysfunction, xenomitochondrial mice exhibited no phenotype, suggest- ing compensatory mechanisms at play ...of mitochondrial depletion can result in cellular damage, ...
10
Translation Studies Orientations: A Case Study on Asian and European Journals
... As for some Asian countries, the pace of knowledge distribution seems to have been slower, compared with European and American countries. Machine Translation (MT), interpretation, translation as a ...
13
Decreased expression of mitochondrial miR-5787 contributes to chemoresistance by reprogramming glucose metabolism and inhibiting MT-CO3 translation
... cisplatin-sensitive TSCC patients had high expression of miR-5787 and MT-CO3 compared to cisplatin- resistant patients (Figure 6A and 6B). Furthermore, Spearman order correlation analysis indicated that miR-5787 was ...
16
The point mutations of mitochondrial tRNA threonine and proline in idiopathic repeated pregnancy loss
... Our data showed that the Mean±SD age of the women with RPL was 28.73±5.86 years and the mean±SD for the gestational age at the time of miscarriages was 10.35±3.75 weeks. These women had the history of 3 to 11 ...
6
“Mitochondrial remodeling” in coronary heart disease
... of mitochondrial calcium extrusion and inhibition of mitochondrial calcium accumulation by temporal ∆Ψ m depolarization, and can confer resistance against subsequent long-lasting mPTP opening in the ...
12