Mitogenic activity
Stress and Atherogenesis: Smooth Muscle Cell Mitogenic Activity and other Biochemical Changes Associated with Sera of "Stressed" Subjects
... for mitogenic activity after the subjects were exposed to one of 2 "stress" ...2). Mitogenic activity was determined by studying the growth stimulatory effects of PDGF-depleted plasma ...
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Effector protease receptor 1 mediates the mitogenic activity of factor Xa for vascular smooth muscle cells in vitro and in vivo
... the mitogenic effect of pro- teolytic enzymes (such as thrombin) for vascular cells is due to the autocrine release of growth factors such as bFGF or PDGF by the ...the activity of several neutralizing mAbs ...
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Platelet factor 4 modulates the mitogenic activity of basic fibroblast growth factor
... Basic fibroblast growth factor (bFGF) has been shown to stimulate cell proliferation after vascular injury. The mitogenic activity of bFGF requires interactions with both a high affinity receptor and a ...
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17 beta estradiol increases mitogenic activity of medium from cultured preadipocytes of massively obese persons
... estradiol, and during the last 24 h the conditioned medium was prepared in the absence of serum. Media from cells of 8 of 13 subjects contained significantly higher mitogenic activity when grown in the ...
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Mechanical strain and collagen potentiate mitogenic activity of angiotensin II in rat vascular smooth muscle cells
... the mitogenic activity of angiotensins I and II (AI and AII) were examined in cultured rat vascular smooth muscle (VSM) ...strain. Mitogenic activity of AI was blocked by ramiprilat (10(-5) ...
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Relationship between mitogenic activity of influenza viruses and the receptor-binding specificity of their hemagglutinin molecules.
... The ability of anti-I-E MAb to block H2 influenza virus-induced mitogenesis and the ability of H2 virus to inhibit the binding of anti-I-E MAb to spleen cells indicate that the B-cell re[r] ...
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The mitogenic activity of human T-cell leukemia virus type I is T-cell associated and requires the CD2/LFA-3 activation pathway.
... Therefore, we evaluated the contribution of viral particles and cell contact to T-lymphocyte activation by examining the ability of purified HTLV-I particles and infected T-cell and non-[r] ...
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Mitogenic activity of the adenovirus type 12 E1A gene induced by hormones in rat cells.
... The variation may merely reflect differences in the amounts of EGF receptor in these clonal cell lines, but it is likely that some other cellular factors besides ElA proteins are require[r] ...
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N-terminal deletion in the src gene of Rous sarcoma virus results in synthesis of a 45,000-Mr protein with mitogenic activity.
... 8 0022-538X/87/082523-07$02.00/0 Copyright © 1987, American Society for Microbiology N-Terminal Deletion in the src Gene of Rous Sarcoma Virus Results in Synthesis of a 45,000Mr Protein [r] ...
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Mitogenic Component in Polar Lipid-Enriched Anaplasma phagocytophilum Membranes
... possessed mitogenic activity ...this activity could not be accounted for by either Msp2 or other ...lymphoproliferative activity beyond that with purified mem- branes ...lymphoproliferative ...
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Biologically active fibroblast growth factor 1 tagged with various epitopes
... Mitogenic activity of FGF1s towards FGFR1c-Ba/F3 ...No mitogenic activity was seen in the absence of heparin (open ...no activity was observed, despite the presence of ...
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Gastrin releasing peptide is a selective mitogen for small cell lung carcinoma in vitro
... immunoreactivity found in SCLC cells. Among four lung cancer cell lines examined in vitro, GRP exhibited mitogenic activity for two SCLC subtypes, but not for a squamous carcinoma or adenocarcinoma lung ...
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Attenuated hypoxic pulmonary hypertension in mice lacking the 5 hydroxytryptamine transporter gene
... mitogenic activity is increased during hypoxia. Here, we report that mice deficient for 5-HTT (5-HTT –/– ) developed less hypoxic pulmonary hypertension and vascular remodeling than paired 5-HTT +/+ ...
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Ascitic fluid from human ovarian cancer patients contains growth factors necessary for intraperitoneal growth of human ovarian adenocarcinoma cells
... vitro mitogenic activity including at least one unique growth ...factor activity, suggesting that the tumors eventually produced autologous growth ...the activity of these growth ...
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A study of Schwann cell survival, proliferation and interaction with neurons
... Following serum exposure for 5 days the mitogenic activity of FGF-2 plus forskolin is more potent in adult Schwann cells than in neonatal cells. The experiments above [r] ...
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Production of platelet derived growth factorlike protein by rat mesangial cells in culture
... competitor activity in mesangial cell conditioned medium (MCCM) is reversible, trypsin sensitive, and inhibited by anti-PDGF ...potent mitogenic activity to ...the mitogenic activity of ...
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Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity A model for intracellular glycosylation in diabetes
... In this study, we have evaluated the effect of in vitro nonenzymatic glycosylation on bFGF heparin-binding activity and its mitogenic activity; characterized the effect of high extracell[r] ...
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Molecular determinants of context-dependent progesterone receptor action in breast cancer
... The mitogenic activity of estrogen is well established, but an under-studied ovarian steroid hormone, progester- one, is emerging as a primary mitogen in the breast, con- tributing significantly to genetic ...
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Antagonistic regulation of the second mitotic wave by Eyes absent Sine oculis and Combgap coordinates proliferation and specification in the Drosophila retina
... terminate mitogenic activity and permit differentiation, while Eya and So, operating as a bipartite transcription factor, take control of the cell cycle by activating a burst of string (stg) transcription ...
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Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice
... transfectants) mitogenic activity for endothelial cells in parallel with enhanced transcription of vascular permeability factor/vascular endothelial cell growth ...
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