mitomycin-C
New Method to Prepare Mitomycin C Loaded PLA Nanoparticles with High Drug Entrapment Efficiency
... Mitomycin C (MMC) is a bifunctional alkylating agent which has been extensively used as an anti-tumor agent for a long time. Because of MMC’s enhanced activity in hypoxic environments [1], it has great ...
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Consecutive bilateral decompression retinopathy after mitomycin C trabeculectomy: a case report
... Three months later, she underwent an uncomplicated left eye trabeculectomy with mitomycin C (0.3 mg/ml, 3 minutes). No postoperative hypotony was registered. On the first postoperative day, the anterior ...
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Single step assembly of polymer lipid hybrid nanoparticles for mitomycin C delivery
... Mitomycin C is one of the most effective chemotherapeutic agents for a wide spectrum of cancers, but its clinical use is still hindered by the mitomycin C (MMC) delivery ...
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Resistance of uveal melanoma to the interstrand cross-linking agent mitomycin C is associated with reduced expression of CYP450R
... Here, we show that UM is resistant in vitro to treatment with the interstrand cross-linking agents MMC and cisplatin but not to the replication inhibitor HU. Mitomycin C induces DNA ICLs, such lesions ...
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Original Article Combination of cryotherapy and mitomycin C in excision for treatment of ocular surface squamous neoplasia
... Abstract: The aim of this study is to retrospectively analyze the treatment outcome of cryotherapy combined with mitomycin C (MMC) after ocular surface squamous neoplasia (OSSN) excision. Nineteen patients ...
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Efficacy and safety of preoperative 5 fluorouracil, cisplatin, and mitomycin C in combination with radiotherapy in patients with resectable and borderline resectable pancreatic cancer: a long term follow up study
... Previous studies concerning 5-FU-based NACRT have been published [17, 33–36]. According to these studies, the resection rate is approximately 60.0–80.0% and the proportion of patients who achieve complete response is ...
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Functional hyper IL 6 from vaccinia virus colonized tumors triggers platelet formation and helps to alleviate toxicity of mitomycin C enhanced virus therapy
... agent mitomycin C to improve not only the oncolytic effect but also the well being of the mice based on the observed effects of ...GLV-1h90. Mitomycin C is known to cause severe ...
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A randomized controlled trial to compare the safety and efficacy of Mitomycin C and Ologen in patients undergoing phacotrabeculectomy
... 0.2mg/ml MMC was applied for 3 minutes after making a fornix based conjunctival flap. In the latter group version 1 of Ologen implant was placed over the sclera flap before closing the conjunctiva. One difference in the ...
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Role of spirulina platensis on mitomycin c induced genotoxicity in ehrlich ascites carcinoma bearing albino mice: single cell gel electrophoresis (comet assay) and semiquantitative rt pcr analysis
... 0.5% low-melting agar (LMA) (in PBS) to prepare the final cell– agarose suspension. The comet assay was performed as described by Singh et al. (1988). From the final cell-agarose suspension, 80 µl was spread over the ...
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Nutrigenomic Study on Immunomodulatory Function of Cordyceps Mycelium Extract (Paecilomyces hepiali) in Mitomycin C–Treated Mice
... CS mycelium culture extract (Paecilomyces hepiali, CBG-CS-2) was prepared by Chebigen Inc. (Jeonju, S. Korea). The CS mycelium extract solution was dissolved in sterile water, and it was orally administered to mice for ...
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Original Article Upregulation of P27 Kip1 by mitomycin C induces fibroblast apoptosis and reduces epidural fibrosis
... To determine the exact effect of P27 on fibro- blast apoptosis, lentiviral-mediated shRNAs were used to knockdown the P27 gene in fibro- blast cells. After successfully knockdown of P27, fibroblasts were treated with 0.4 ...
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Density functional theory studies on the geometry and electronic properties of Mitomycin C, DNA Base Pairs and their complex
... molecule mitomycin C (MC) and DNA base ...intercalator mitomycin C (MC) and their stacking interactions with the adenine···thymine (AT) and guanine···cytosine (GC) nucleic acid base pairs were ...
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A Clinical Study of Pterygium and Results of Treatment by Excision and Limbal Autograft or Augmented with Post Op Mitomycin C
... Aim: To prospectively analyze the clinical profile of pterygium and to compare results of management by excision with limbal conjunctival autograft or postoperative topical Mitomycin C drops. Methodology: ...
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Comparing the cytotoxicity of taurolidine, mitomycin C, and oxaliplatin on the proliferation of in vitro colon carcinoma cells following pressurized intra peritoneal aerosol chemotherapy (PIPAC)
... Intraperitoneal chemotherapy (IPC) has gained increasing acceptance in the past 20 years and has since been fre- quently used and extensively studied. Limitations concern- ing drug delivery to solid cancer formations ...
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Pulmonary toxicity after intraperitoneal mitomycin C: a case report of a rare complication of HIPEC
... toneal mitomycin C and development of pulmonary toxicity also favors drug toxicity as the inciting cause for ...systemic mitomycin C and development of interstitial pneumonitis, the pulmonary ...
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The histopathological effects of intracavernosal mitomycin C injection in a rat Peyronie's disease model
... When compared with group 3 (sham group), previously described semiquantitative scores evaluating fibrosis were higher in both group 1 and group 2, and this finding was statistically significant (Table 1) (Fig. ...
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Study on the role of mitomycin C in the Management of ocular surface squamous neoplasia
... by C Chen, D Louis, T Dodd, J Muecke between 1998-2003(Br J Ophthalmol 2004; ...intraoperative mitomycin c was not given. Topical mitomycin c was given only ...of Mitomycin ...
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VEGF111b, a C terminal splice variant of VEGF A and induced by mitomycin C, inhibits ovarian cancer growth
... Vascular endothelial growth factor (VEGF-A) has been identified in a number of studies as a key component in tumor growth and angiogenesis [5]. It has been proved that, the positive expression of VEGF and its receptor ...
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Low Releasing Mitomycin C Molecule Encapsulated with Chitosan Nanoparticles for Intravesical Installation
... tionally, Mitomycin-C, Epirubicin and Doxorubicin can be used for a single, im- mediate, post-operative intravesical instillation after resection of the tumor [6] ...
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The histopathological effects of intracavernosal mitomycin C injection in a rat Peyronie's disease model
... staining can be used for evaluating the fibrosis level. Mitomycin-C (MMC), a chemotherapeutic agent, shows antitumoural and antifibrotic activity. Occleston et al report- ed that MMC reduced fibrosis on ...
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