Mitotic spindle
Transient defects of mitotic spindle geometry and chromosome segregation errors
... the mitotic spindle have a dramatic impact on chromosome ...the spindle defects are only transient. Indeed, whereas permanent spindle defects typically lead to cell death in the pro- geny, ...
8
Mitotic spindle destabilization and genomic instability in Shwachman Diamond syndrome
... Deficiencies in the SBDS gene result in Shwachman-Diamond syndrome (SDS), an inherited bone marrow failure syndrome associated with leukemia predisposition. SBDS encodes a highly conserved protein previously implicated ...
9
FGFR3–TACC3 cancer gene fusions cause mitotic defects by removal of endogenous TACC3 from the mitotic spindle
... the mitotic spindle was lower compared with CD8- mCherry alone (figure ...mal mitotic figures in the presence of CD8-TACC3-mCherry compared with CD8-mCherry (figure ...4c). Mitotic progression ...
12
Molecular pathways regulating mitotic spindle orientation in animal cells
... 1. Spindle positioning regulates oriented/asymmetric cell division during metazoan ...(A) Spindle orientation regulates asymmetric cell divisions in early ...(red). Spindle orientation is coupled to ...
14
Plk2 regulates mitotic spindle orientation and mammary gland development
... altered mitotic spindle orientation, unfortunately these two phenomenon are observed simultaneously, which makes it difficult to decipher which arises ...
10
Effect of SP600125 on the mitotic spindle in HeLa Cells, leading to mitotic arrest, endoreduplication and apoptosis
... Faithful transmission of genetic information during mi- tosis is ensured by the spindle assembly checkpoints [1]. Cell cycle progression to the G1, S, and G2/M phases is controlled by those cell cycle checkpoints ...
7
Hsp72 is targeted to the mitotic spindle by Nek6 to promote K fiber assembly and mitotic progression
... attach spindle poles to ...the mitotic spindle ...from mitotic cells with TACC3 and ch-TOG but not the spindle-associated Cep55, whereas their association with Hsp72, but not their ...
10
Molecular Analysis Reveals Localization of Saccharomyces cerevisiae Protein Kinase C to Sites of Polarized Growth and Pkc1p Targeting to the Nucleus and Mitotic Spindle
... The activities of many proteins are regulated through their subcellular localization; directing enzymes to specific struc- tures or compartments affects their proximity to both upstream regulators and substrates. The ...
10
Kinetochore dynamics and their attachment to the mitotic spindle
... The SAC is required in all cells to ensure that every chromosome is aligned at the spin- dle equator and correctly attached to the mitotic spindle. Once all chromosomes are bi- orientated, the SAC becomes ...
268
The mitotic spindle protein SPAG5/Astrin connects to the Usher protein network postmitotically
... correct mitotic spindle formation, sister chromatid cohe- sion and centrosome integrity ...and spindle assembly, and NINL abnormalities may contribute to genomic instability and tumorigenesis ...
12
The mesh is a network of microtubule connectors that stabilizes individual kinetochore fibers of the mitotic spindle
... a mitotic spindle which, in concert with hundreds of different motors and non- motor proteins, segregates the duplicated sister chromatids to the two daughter ...the spindle pole (McDonald et ...
22
Regulated Assembly of the Mitotic Spindle: A Perspective from Two Ends
... A second component linking two half spindles together involves chromosome interactions with microtubules via the kinetochore. Kinetochores are unique protein complexes assembled onto the single centromere DNA region of ...
15
Human Papillomavirus Oncoproteins E6 and E7 Independently Abrogate the Mitotic Spindle Checkpoint
... the metabolic inhibitor PALA as well as CAD gene amplifica- tion (64). In contrast, E7-expressing cells display massive cell death with the rare appearance of PALA-resistant aneuploid cells, which occurs by a ...
7
Mitotic Spindle Form and Function
... and spindle poles through the mitotic and meiotic ...“omics”), spindle dynamics in live cells, and a glimpse of what would be forthcoming from green fluorescent protein fusions (through tubulin-GFP) ...
28
Characterization of Skeletor: a novel nuclear protein implicated in mitotic spindle assembly
... This interpretation is supported by our findings that I multiple antibodies generated against Skeietor sequences identify a dynamic, cell cycle specific nuclear structure that has many o[r] ...
158
Regulation of Mitotic Spindle Disassembly by an Environmental Stress-Sensing Pathway in Budding Yeast
... in spindle disas- sembly even under unstressed conditions, but also raise the question of how the HOG pathway, which depends on hier- archical activation of kinases Pbs2 and Hog1 via a MAPK signaling cascade, ...
24
Spindle Assembly and Chromosome Segregation Requires Central Spindle Proteins in Drosophila Oocytes
... in mitotic spindle midzone formation and stabilization leading to cytokinesis is well documented (Guse et ...acentrosomal spindle assembly, however, has not been ...meiotic spindle assembly, ...
32
Characterization of three spindle matrix proteins, Megator, EAST and Asator, in Drosophila
... The mitotic spindle consists of microtubules and a variety of microtubule-associated ...the spindle is an antiparallel array of microtubules ...
143
Dual mechanism controls asymmetric spindle position in ascidian germ cell precursors
... how spindle orientation is maintained until the cytokinetic furrow is established and cell fate determinants have been ...the mitotic spindle (midzone and/or astral microtubules) late during ...
11
PubMedCentral-PMC5101839.pdf
... Recently, the concept of the “histone code” has been parlayed into a “tubulin code” hypothesis to describe how PTMs distinctly mark subsets of microtubules in the cytoskeleton (Verhey and Gaertig, 2007). The cytoskeleton ...
24