mixed-lineage kinase
Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosis.
... to Mixed Lineage Kinase 3 via a Conserved Poly- proline Motif—NS5A interacts with a range of host cell proteins to modulate their function and promote virus replication and ...
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Pivotal Role of Receptor-Interacting Protein Kinase 1 and Mixed Lineage Kinase Domain-Like in Neuronal Cell Death Induced by the Human Neuroinvasive Coronavirus OC43
... protein kinase 1 (RIP1) and RIP3 interacting with each other ...of mixed lineage kinase domain-like (MLKL) and ultimately in cell death ...
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Genetic Analysis of Slipper/Mixed Lineage Kinase Reveals Requirements in Multiple Jun-N-Terminal Kinase-Dependent Morphogenetic Events During Drosophila Development
... Previously, we identified Drosophila slipper (slpr), en- coding a mixed lineage kinase (MLK), as an upstream kinase stimulating the JNK pathway controlling the mor- phogenetic process of ...
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Low expression of mixed lineage kinase domain-like protein is associated with poor prognosis in ovarian cancer patients
... Our study demonstrated that expression of a protein involved in necroptosis exhibits prognostic value in ovarian cancer patients, suggesting that necroptosis may play an important rol[r] ...
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The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-β degradation
... as mixed glial cultures in Dulbecco’s modified eagle medium supplemented with heat-inactivated 10 % fetal bovine serum, 50 μg/ml penicillin/streptomycin (Life Technologies, Carlsbad, CA, USA) and macrophage ...
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Mixed-lineage kinase 3 pharmacological inhibition attenuates murine nonalcoholic steatohepatitis
... that URMC099 treatment exerts a direct inhibition of MLK3 downstream targets, we demonstrate signifi- cant reduction of the FFC diet–induced phosphorylation of the mitogen-activated prot[r] ...
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The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders
... URMC-099’s kinase se- lectivity using a kinome-wide scanMAX assay, which revealed that URMC-099 potently inhibits tens of kinases with > 99% inhibition at 1 μM ...
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Conditional knockout of TGF-βRII /Smad2 signals protects against acute renal injury by alleviating cell necroptosis, apoptosis and inflammation
... chemotactic protein-1; MLKL: mixed lineage kinase domain like pseudokinase; RIPK: Receptor- interacting serine/threonine-protein kinase; S2FF: Smad2 flox/flox mouse; S2 KspCre: cond[r] ...
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Necroptosis: a new link between cell death and inflammation
... DAMPs: damage associated molecular patterns; MLKL: mixed lineage kinase domain-like protein; TNF: tumour necrosis factor; TNFR: tumour necrosis factor receptor; cIAP: calf intestinal al[r] ...
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JNK-signaling: A multiplexing hub in programmed cell death
... Protein Kinase or RIP3. Activated RIP3 and the downstream pseudokinase Mixed-Lineage kinase domain Like (MLKL) oligomers form a necrosome complex and translocate to mitochondria-associated ...
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O-GlcNAc transferase suppresses necroptosis and liver fibrosis
... Worldwide, over a billion people suffer from chronic liver diseases, which often lead to fibrosis and then cirrhosis. Treatments for fibrosis remain experimental, in part because no unifying mechanism has been identified ...
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Mixed Genome Microarrays Reveal Multiple Serotype and Lineage Specific Differences among Strains of Listeria monocytogenes
... As illustrated in this study, mixed-genome microarrays present several unique advantages for characterizing clinically relevant microbes. First, these arrays are relatively simple to construct and use, making them ...
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Roles for common MLL/COMPASS subunits and the 19S proteasome in regulating CIITA pIV and MHC class II gene expression and promoter methylation
... Janus kinase/signal transducer and activator of tran- scription 1 (JAK/STAT) pathway is triggered, leading to pIV accumulation of the requisite transcription factors, and the initiation of CIITA transcription ...
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A SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesis
... with mixed-lineage leukemia (MLL) and co-occupied the HOXA9 promoter region with MLL in AML leuke- mic cells, which suggests that a SALL4/MLL pathway may control HOXA9 ...
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Modern social structure and social organization in Upper Mandailing, Sumatra
... X Chapter 6 : THE LINEAGE SYSTEM Sibling groups The ompu Property and the lineage Jural unity and the lineage The minimal lineage as the paradigm of social relations within the descent g[r] ...
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Whole genome sequencing reveals high-resolution epidemiological links between clinical and environmental Klebsiella pneumoniae
... The detection of carbapenem-resistant isolates in pre- treated hospital wastewater reiterates the importance of the treatment of hospital wastewater prior to release into the environment [40, 41]. Our study also ...
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Epidemiology of Acute Lymphoblastic Leukemia with reference to prevalence and genetics
... Mixed phenotype is rare 4% in ambiguous lineage co-exist with two separate blast cells T-or B-cells acute lymphoblastic leukemia either myeloid or monocytic blast cells [r] ...
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The stem cell factor SALL4 is an essential transcriptional regulator in mixed lineage leukemia-rearranged leukemogenesis
... isolated lineage negative (Lin-) BM cells from 5-fluorouracil- primed Sall4 f/f CreER T2 mice and transduced them with a retroviral pMSCV-IRES-MLL-AF9 vector by spinocu- lation on three consecutive ...
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MicroRNA-205 downregulates <em>mixed-lineage-AF4</em> oncogene expression in acute lymphoblastic leukemia
... Abstract: Myeloid/lymphoid or mixed-lineage AF4 acute lymphoblastic leukemia (MLL-AF4 ALL) is a pediatric leukemia that occurs rarely in adults. MLL-AF4 ALL is typically character- ized by the presence of ...
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The Histone Methyltransferase Mixed Lineage Leukemia (MLL) 3 May Play a Potential Role in Clinical Dilated Cardiomyopathy
... There is accumulating evidence demonstrating that histone methylation and HMTs contribute to heart develop- ment and to congenital and adult heart diseases (26,27). Lysine methyltrans- ferase G9a and G9a-like protein ...
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