Mixed Micelles
Comparative Study of Pure Micelles and Mixed Micelles in the presence of Polymer
... The mixed micelles are considered to be more versatile than single surfactants in view of their wide industrial applications and hence the evaluation of their physiochemical properties has recently ...
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SIMVASTATIN LOADED NANO MIXED MICELLES: AN APPROACH TO TREAT HORMONE DEPENDENT CARCINOMAS
... develop mixed micelles using two biocompatible copolymers, D-α-tocopheryl polyethylene- glycol 1000 succinate (TPGS) and poloxamer 188 (P188) to improve the aqueous solubility and targeting efficacy of ...
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Polymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy
... treated with MIT and MIT-PFP/PPP mixed micelles at various concentrations ranging from 2.5 to 20 μ M. After incubation for 4 h, the original medium was discarded and fresh medium containing 0.5% FBS was ...
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EVALUATION OF THE USE OF ANIONIC/ NONIONIC MIXED MICELLES IN REVERSED PHASE LIQUID CHROMATOGRAPHY OF CHLOROPHENOLS
... In MLC using SDS/Brij-35 mixed micellar eluent, a good correlation (r>0.99) between 1/K′ and total surfactant concentration was observed for all solutes (Table 4). Our results show that the solutes studied in ...
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mPEG-PLA/TPGS mixed micelles via intranasal administration improved the bioavailability of lamotrigine in the hippocampus
... between micelles and mixed micelles was the boundary of the shell, and the shell of the mixed micelle was formed by the inter- action of TPGS and mPEG-PLA, which made the shell compact and ...
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Pluronic mixed micelles overcoming methotrexate multidrug resistance: in vitro and in vivo evaluation
... the tumor-bearing mice were injected with 100 µ L DIR- labeled P105/F127 mixed micelles (DIR content: 0.2%) through the tail vein. At predetermined time points, the mice were sacrificed and major organs ...
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Preparation of ginsenoside compound-K mixed micelles with improved retention and antitumor efficacy
... CK mixed micelles, expression of the apoptosis-associated proteins caspase-3, caspase-8, and caspase-9 increased by ...CK mixed micelles exhibit low tissue toxicity and a greater antitumor ...
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Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol
... Novel mixed polymeric micelles formed from biocompatible polymers, poly(ethylene glycol)-poly(lactide) (mPEG- PLA) and polyoxyethylene-660-12-hydroxy stearate (Solutol HS15), were fabricated and used as a ...
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Ascorbyl palmitate/d-α-tocopheryl polyethylene glycol 1000 succinate monoester mixed micelles for prolonged circulation and targeted delivery of compound K for antilung cancer therapy in vitro and in vivo
... (TPGS) mixed micelles were prepared as a delivery system to increase the absorption and targeted antitumor effect of ...AP/TPGS mixed micelles significantly inhibited cell growth, induced ...
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<p>Liver-Targeting and pH-Sensitive Sulfated Hyaluronic Acid Mixed Micelles for Hepatoma Therapy</p>
... sHA-DOX micelles, HA-GA micelles, and sHA-DOX/HA-GA mixed micelles were ...sHA-DOX micelles, the particle size of mixed micelles decreased due to the hydrophobic GA group ...
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Redox-responsive F127-folate/F127-disulfide bond-D-α-tocopheryl polyethylene glycol 1000 succinate/P123 mixed micelles loaded with paclitaxel for the reversal of multidrug resistance in tumors
... is a triblock copolymer, which is composed of hydrophilic polyoxyethylene (70%) and hydrophobic polyoxypropylene (30%). The molecular weight and segment length of TPGS are obviously smaller than F127. Therefore, it is ...
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pH-sensitive and folic acid-targeted MPEG-PHIS/FA-PEG-VE mixed micelles for the delivery of PTX-VE and their antitumor activity
... (PTX-VE)-loaded mixed micelles (PHIS/FA/PM) fabricated by poly(ethylene glycol) methyl ether-poly(histidine) (MPEG-PHIS) and folic acid- poly(ethylene glycol)-(+)-α-tocopherol (FA-PEG-VE) were characterized ...
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Enhancing the oral bioavailability of biochanin A by encapsulation in mixed micelles containing Pluronic F127 and Plasdone S630
... Caco-2 transport studies were initiated by removing the medium from both sides of the monolayer, followed by replacement with apical (AP) and basolateral (BL) buffers prewarmed to 37 ° C. The cell monolayers were ...
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Poloxamer 407/TPGS mixed micelles for delivery of gambogic acid to breast and multidrug-resistant cancer
... design mixed micelles composed of Poloxamer 407 and TPGS loaded with the poorly soluble natural anticancer agent, ...The micelles have a low CMC, small particle size and high encapsula- tion ...the ...
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Effect of Polymer Concentration on the Interaction of Mixed Micelles and Polymers
... saturation of the polymere. The Brij56+CTAB show similar tensiometric profiles as shown by the individual surfactants with the same poymer. The CMC of Brij56+CTAB shows generally first increase with increase in polymer ...
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Soluplus Based Polymeric Micelles and Mixed Micelles of Lornoxicam: Design, Characterization and In vivo Efficacy Studies in Rats
... its mixed micellar systems could effectively form stable micelles with mean diameter in range of 60-70 nm and promising LNX loading ...stable mixed micelles with other micelle forming agents ...
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Comparison of bile salt/phosphatidylcholine mixed micelles in solubilization to sterols and stability
... salt/phosphatidylcholine mixed micelles ...stable mixed micelles with high drug ...drug-loaded mixed micelles is quite different, which might be related to the change in critical ...
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Nimodipine-loaded mixed micelles: formulation, compatibility, pharmacokinetics, and vascular irritability study
... was mixed with 25 µ L of internal standard (nitrendipine at a concentration of 0.0020 mg/mL in methanol), followed by vortex mixing for 1 minute. Then, 50 µ L of 1 mol/L NaOH was added and the mixture was ...
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Development of Polysorbate 80/Phospholipid mixed micellar formation for docetaxel and assessment of its in vivo distribution in animal models
... 80/Phospholipid mixed micelles and revealed the efficient encapsulation of DTX in the mixed micelles by using the self-assembly method ...centrated mixed solution containing Polysorbate ...
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Original Article Doxorubicin-loaded Pluronic P123-PEG2000-DSPE micelles reverse the drug resistance of breast cancer cells
... polymer micelles with the advantage of simple prepara- tion can improve drug distribution and prolong drug cycle ...polymer micelles are a supramo- lecular ordered aggregation of amphiphilic block ...
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