molecular chaperone
Involvement of the molecular chaperone BiP in maturation of Sindbis virus envelope glycoproteins.
... the molecular chaperone BiP to reversibly bind to regions of polypeptide and prevent them from interacting with other regions gives BiP the potential to guide the formation or reshuffling of disulfide bonds ...
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The Archaeal Molecular Chaperone Machine: Peculiarities and Paradoxes
... and molecular chaperones has been the demonstration that, while some species have the stress (heat-shock) gene hsp70(dnaK ), others do ...essential molecular chaperone in bacteria and ...the ...
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The ATPase activity of molecular chaperone HSP60 is inhibited by immunosuppressant mizoribine
... The molecular chaperone HSP60 is a chaperonin ho- molog of GroEL. We had previously shown that the immunosuppressant mizoribine is bound directly to HSP60 and inhibited its chaperone activity. ...
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A Role for Molecular Chaperone Hsc70 in Reovirus Outer Capsid Disassembly
... of molecular chaperones, it is not surprising that they play numerous roles in the life cycles of different ...ular chaperone expression and/or relocalization, and in some cases, this induction has been ...
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Molecular Chaperone Hsp90 Is Important for Vaccinia Virus Growth in Cells
... constitutive molecular chaperone present in eu- karyotes and bacteria (39, ...the chaperone function of Hsp90 and for conformational changes involved in refolding protein substrates or client ...
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Molecular chaperone GRP78 enhances aggresome delivery to autophagosomes to promote drug resistance in multiple myeloma
... The molecular chaperone GRP78 is induced under stress conditions such as glucose starvation, hypoxia and oxidative stress, which are characteristic of the tumor ...
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The potent bone resorbing mediator of Actinobacillus actinomycetemcomitans is homologous to the molecular chaperone GroEL
... chromatography and the NH2-terminal sequence shows > 95% homology to E. coli GroEL. This GroEL homologue is found in the SAM of A. actinomycetemcomitans but is not found in the osteolytically active SAM from other ...
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Lead identification of beta lactam and related imine inhibitors of the molecular chaperone heat shock protein 90
... 21. Woodhead, A. J.; Angove, H.; Carr, M. G.; Chessari, G.; Congreve, M.; Coyle, J. E.; Cosme, J.; Graham, B.; Day, P. J.; Downham, R.; Fazal, L.; Feltell, R.; Figueroa, E.; Frederickson, M.; Lewis, J.; McMenamin, R.; ...
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Calnexin acts as a molecular chaperone during the folding of glycoprotein B of human cytomegalovirus.
... that molecular chaperones such as BiP/GRP78 as well as folding enzymes play an important role in the quality control system in the ER (24, ...a chaperone in the ER ...a molecular chaperone ...
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Temperature interactions of the molecular chaperone Hsc70 from the eurythermal marine goby Gillichthys mirabilis
... the chaperone cycle: the non-native protein and the ...the molecular chaperone, temperature will interact with both the rate of the chaperone cycle and the nature of substrate ...a ...
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A Targetable Molecular Chaperone Hsp27 Confers Aggressiveness in Hepatocellular Carcinoma
... ATP-independent molecular chaperone and confers survival advantages and resistance to cancer cells under stress ...and molecular mechanisms of Hsp27 in HCC invasion and metastasis are still ...
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Molecular Chaperone Hsp90 Is a Therapeutic Target for Noroviruses
... Using a riboproteomics-based approach, we recently identified heat shock protein 90 (Hsp90) as one component of a network of host proteins that interact directly or indirectly with the 5= and 3= extremities of the MNV-1 ...
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Alteration of the Protein Kinase Binding Domain Enhances Function of the Saccharomyces cerevisiae Molecular Chaperone Cdc37
... The CDC37 gene product is thought to function as a protein kinase-specific molecular chaperone that functions in associa- tion with Hsp90. Accordingly, the CDC37 dominant mutations may suppress the ...
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The Molecular Chaperone Calnexin Interacts with the NSP4 Enterotoxin of Rotavirus In Vivo and In Vitro
... Calnexin is an endoplasmic reticulum (ER)-associated molecular chaperone proposed to promote folding and assembly of glycoproteins that traverse the secretory pathway in eukaryotic cells. In this study we ...
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A molecular chaperone for mitochondrial complex I assembly is mutated in a progressive encephalopathy
... the molecular chaperones required for assembly of the mammalian enzyme remain ...fide molecular chaperone that is essential for the assembly of complex I and for the normal function of the nervous ...
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Endothelial cell α globin and its molecular chaperone α hemoglobin–stabilizing protein regulate arteriolar contractility
... tures rapidly in cells and is eliminated by protein quality control mechanisms (18) or forms toxic precipitates (22, 25). During RBC formation, AHSP acts as a molecular chaperone to stabilize α-globin ...
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Expression of the endoplasmic reticulum molecular chaperone (ORP150) rescues hippocampal neurons from glutamate toxicity
... extract of the hippocampal region 8 hours after the administration of kainate (c). Upper and lower arrowheads indicate the preactivated and activated forms of µ -calpain, respectively. Migration of molecular ...
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Steroid resistance in COPD is associated with impaired molecular chaperone Hsp90 expression by pro-inflammatory lymphocytes
... For both COPD groups and controls, a significantly lower percentage of CD28nullCD8+ T and NKT-like cells expressing Hsp90 was found, compared with CD28+ T and NKT-like cells (data for T [r] ...
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The molecular chaperone dnak is a source of mutational robustness
... Hsp70 chaperone DnaK helps cells cope with mutational load and completely avoid the extinctions we observe in lineages evolving without chaperone ...major chaperone classes can buffer mutations and ...
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An erythroid chaperone that facilitates folding of α globin subunits for hemoglobin synthesis
... the molecular chaperone BiP ...the molecular chaperone activities of ...protein–specific molecular chaperones func- tion in the assembly of tubulin (54, 55) and collagen (56, 57), mul- ...
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