Molecular Chaperones
A REVIEW ON MOLECULAR CHAPERONES AND CHAPERONE OVERLOAD
... The molecular chaperones are the molecules that help the cell in effective refolding of misfolded proteins and also removal of proteins that cannot be refolded ...These chaperones are produced in the ...
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Polyomavirus T Antigens: Molecular Chaperones for Multiprotein Complexes
... domain, after which two T-antigen hexamers associate at ori in an ATP-dependent reaction. T antigen then recruits cellular proteins such as DNA polymerase a, primase, topoisomerase, and RPA to the complex via direct ...
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Molecular chaperones and protein folding as therapeutic targets in Parkinson’s disease and other synucleinopathies
... [16-18,21,22]. Molecular chaperones are crucially involved in protein folding and refolding and thus are promising targets that have the potential to alter early pathological changes in synucleinopathies, ...
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Congenital hypothyroid goiter with deficient thyroglobulin Identification of an endoplasmic reticulum storage disease with induction of molecular chaperones
... the molecular pathogen- esis of congenital hypothyroid goiter in cog / cog mice, have raised important questions concerning the maturation of thyroglobulin (the thyroid prohormone) in certain human kindreds with ...
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Sikor, Martin (2011): Single-molecule fluorescence studies of Protein Folding and Molecular Chaperones. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... A huge machinery of specialized proteins, the molecular chaperones, has evolved to assist protein folding in the cell. Using single molecule fluorescence spectroscopy, I have studied several members of this ...
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Oolemmal proteomics – identification of highly abundant heat shock proteins and molecular chaperones in the mature mouse egg and their localization on the plasma membrane
... alone did not result in any antibody reactivity (Fig. 3B). It is not clear from these preliminary results what common feature this subpopulation of positively staining eggs shared in common, but there does not appear to ...
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Prion protein PrPc interacts with molecular chaperones of the Hsp60 family.
... the molecular chaperones which mediate ATP-depen- dent folding of polypeptide chains (13, 18, 22, 23) and which are widely distributed and conserved between prokaryotes and ...
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Why Molecular Chaperones Buffer Mutational Damage: A Case Study With a Yeast Hsp40/70 System
... 2002). Molecular chaperones seem to be an especially plausible example of such ...the chaperones GroEL or DnaK are overexpressed (F ares et ...of chaperones were enhanced, there is no evidence ...
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Behrends, Christian (2007): Proteotoxicity of polyglutamine expansion proteins: Cellular mechanisms and their modulation by molecular chaperones. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... pathways. Molecular chaperones might counteract these aberrant protein interactions, presumably by shielding hydrophobic ...of chaperones frequently relieves toxicity associated with aggregation ...
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Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function
... these molecular chaperones in the pathome- chanism of myopathy subtypes, which are presenting with reduced contractile force generation and increased muscle ...
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Molecular chaperones and selection against mutations
... and molecular mechanisms is especially difficult if complex traits, such as fitness or health, are ...of chaperones at the level of whole cells or organisms is hardly possible considering the present state ...
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The redox switch that regulates molecular chaperones
... The endoplasmic reticulum (ER) hosts a network of highly regulated mechanisms governed by molecular chaperones and folding enzymes that facilitate the translation and correct folding of proteins. The ...
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BiP and Multiple DNAJ Molecular Chaperones in the Endoplasmic Reticulum Are Required for Efficient Simian Virus 40 Infection
... Cells and viruses. CV1 cells, 293T cells, BKV, and SV40 DNA were pur- chased from the American Type Culture Collection (ATCC). HeLa/E6 cells are a clonal line of HeLa cells constitutively expressing an exogenous HPV16 E6 ...
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Fellerer, Christine (2012): Molecular chaperones involved in preprotein targeting to plant organelles. Dissertation, LMU München: Fakultät für Biologie
... The molecular chaperone HSP70 is the most prominent representative of the heat shock protein family ubiquitously found in pro- and eukaryotes. It plays a crucial role in stress protection and protein folding. ...
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RNAi-dependent heterochromatin assembly in fission yeast Schizosaccharomyces pombe requires heat-shock molecular chaperones Hsp90 and Mas5
... As molecular chaperone proteins, Hsp90 and Mas5 may contribute to effector complex formation in the RNAi pathway. To examine this possibility, we first tested whether the protein level of Ago1 is altered in the ...
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Polier, Sigrun (2009): Structural Basis for the Cooperation of Hsp110 and Hsp70 Molecular Chaperones in Protein Folding. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... upstream chaperones such as the ribosome-bound folding helpers and downstream components such as the chaperonins, Hsp90, Hsp100, the proteasome, or the mitochondrial import receptor TOM70 (70 kDa translocase of ...
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The evolution of molecular chaperones and their clients
... both group I and group II sequences are present in certain bacteria; GroEL and its homologues buffer the accumulation of mutations in their client proteins, at least among the gamma-prot[r] ...
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The involvement of heat shock protein molecular chaperones in MHC class II antigen processing and presentation
... understanding the nature of the converse chaperone function, i.e., antigen release are now discussed. As described in Introduction (section 4.2.1), one of the most compelling scenarios for chaperone action in APCs is ...
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A family of cyclophilin like molecular chaperones in Plasmodium falciparum
... We assessed the molecular chaperone ability of the recombinant cyclophilins using.. two model substrates: rhodanese from bovine liver mitochondria and citrate synthase from.[r] ...
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Intracellular protozoan parasites of humans: the role of molecular chaperones in development and pathogenesis
... Expression of Toxoplasma gondii -specific heat shock protein 70 during in vivo. 1326[r] ...
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