molecular determinants
Molecular determinants of acute inflammatory responses to biomaterials
... Thus, this is by no means the first indication of a possible causal connection between the deposition of fibrin(ogen) and promotion of inflammation. However, to the best of our knowledge the present results constitute ...
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Molecular Determinants of Virulence, Cell Tropism, and Pathogenic Phenotype of Infectious Bursal Disease Virus
... the molecular determinants for the virulence, pathogenic phenotype, and cell tropism of IBDV, we prepared full-length cDNA clones of a virulent strain, Irwin Moulthrop (IM), and constructed several chimeric ...
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Molecular determinants of uterine receptivity
... Molecular determinants of uterine receptivity ZHAOWEI TU#,1,2, HAO RAN#,1,3, SHUANG ZHANG1, GUOLIANG XIA3, BINGYAN WANG*,1 and HAIBIN WANG*,1 1State Key Laboratory of Reproductive Biology, Institute o[.] ...
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Identification of molecular determinants of cell culture growth characteristics of Enterovirus 71
... main determinants for the attenuated phenotype (C274U in IRES, C2034U in VP3, and U2493C in VP1) ...the molecular deter- minants of cell culture growth, in vitro construction of polioviruses with ...
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Molecular Determinants for Subcellular Localization of the Severe Acute Respiratory Syndrome Coronavirus Open Reading Frame 3b Protein
... The molecular mechanism regulating the timing of nucleo- mitochondrial translocation of ORF 3b protein remains to be determined. We have been unable to detect any evidence of posttranslational modifications of ORF ...
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Molecular determinants for virulence in coxsackievirus B1 infection.
... the molecular determinant(s) for the difference in virulence between these two viruses, we prepared chimeras between the cDNAs and investigated the 50% lethal dose (LD 50 ) of the recombinant ...
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Clinical and molecular determinants of extrahepatic disease progression in patients with metastatic colorectal cancer with liver-limited metastases deemed initially unresectable
... We acknowledge some limitations of our work, including the relatively small sample size and the retro- spective collection of clinical data. Moreover, given the strong impact of a post-baseline variable, such as surgical ...
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Molecular Determinants of Antiviral Potency of Paramyxovirus Entry Inhibitors
... Hendra virus (HeV) and Nipah virus (NiV) constitute the Henipavirus genus of paramyxoviruses, both fatal in humans and with the potential for subversion as agents of bioterrorism. Binding of the HeV/NiV attachment ...
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Unravelling the molecular determinants of bee sensitivity to neonicotinoid insecticides
... the molecular and biochemical basis of pesti- cide selectivity [15, 25–29], can facilitate the development of compounds that show high efficacy against crop pests but low toxicity to nontarget beneficial ...
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The molecular determinants and consequences of recombination in the evolution of human enteroviruses
... precursor protein before cleavage to make VP2 and VP4 capsid protein capsid protein capsid protein capsid protein virus protease precursor protein, interacts with cellular membranes inte[r] ...
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Molecular determinants of rotavirus virulence
... Diarrhoea produced by B223 strain of rotavirus in 7 day old suckling pups of various mice strains... Replication of OSU strain of rotavirus in 7 day X..[r] ...
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Discovering early molecular determinants of leukemogenesis
... early molecular steps in this and other neoplastic processes represent adaptations in which, through somatic mutations, “unfit” stem cells gain a measure of fitness by altering their relationships with ...
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Molecular Determinants of Sporulation in Ashbya gossypii
... In kar3 mutants sporulation is severely reduced, while deletion of KAR4 as well as of homologs of central Saccharomyces cerevisiae regulators of sporulation, IME1 , IME2 , IME4 , and NDT[r] ...
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A review of soft-tissue sarcomas: translation of biological advances into treatment measures
... many molecular aberrations are prevalent within specific sarcomas, very few are therapeutically ...utilizing molecular signatures, first-line sarcoma treatment options are still limited to traditional ...
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Molecular Analysis of an Echovirus 3 Strain Isolated from an Individual Concurrently with Appearance of Islet Cell and IA 2 Autoantibodies
... of islet cells. Over the past few years, a number of studies have reported an association between enteroviruses and diabetes on the basis of reverse transcription (RT)-PCR amplification from clinical material, using ...
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Viral determinants of simian immunodeficiency virus (SIV) virulence in rhesus macaques assessed by using attenuated and pathogenic molecular clones of SIVmac.
... In this study, infection of rhesus macaques with recombinant viruses showed a spectrum of virulence between the parent viruses, SIVmaclA1l and SIVmac239; thus, molecular determinants of [r] ...
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Roles Played by Capsid-Dependent Induction of Membrane Curvature and Gag-ESCRT Interactions in Tetherin Recruitment to HIV-1 Assembly Sites
... HIV-1 encodes four accessory genes that have been implicated in combating host defense responses (Vif, Vpr, Vpu, and Nef) (82), exemplifying the necessity for immune evasion by successful viral pathogens. Such ...
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Stimulation of histamine release from human basophils by human platelet factor 4
... That a similar maximal release of histamine from human basophils was evoked by PF4 and PF459-70 suggested that the molecular determinants critical for basophil activation are located in [r] ...
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Identification of a single amino acid residue in the capsid protein VP1 of coxsackievirus B4 that determines the virulent phenotype.
... 4797 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest To identify the molecular determinants of virulence for coxsackievirus B4, a panel of recombinant, chimeric viruses [r] ...
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Characterization of the Self-Resistance Mechanism to Dityromycin in the Streptomyces Producer Strain
... the molecular determinants of the dityromycin resistance identified in Streptomyces can be transferred to Escherichia coli ribosomes, where they can trigger the same antibi- otic resistance mechanism found ...
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