molecular subtype
Impact of established prognostic factors and molecular subtype in very young breast cancer patients: pooled analysis of four EORTC randomized controlled trials
... and molecular sub- type were significantly associated with overall survival and distant metastasis free survival (Supplementary Table S2 in Additional file ...of molecular subtype, histological grade ...
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Molecular subtype analysis determines the association of advanced breast cancer in Egypt with favorable biology
... to molecular subtype, tumors from Minia represented the majority of Luminal B and basal-like tumors and also demonstrated significantly fewer unclassified cases than ones from ...tological subtype ...
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Baseline staging tests based on molecular subtype is necessary for newly diagnosed breast cancer
... Molecular subtype classification is a breakthrough in breast cancer research [9-11]. Different subtypes have different epidemiological risk factors, natural histories, and responses to treatment, which ...
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Prognosis Comparison Molecular Subtype Breast Cancer between Young and Adult Women at General Hospital Dr. M Djamil Padang
... certain molecular subtype from old aged breast cancer patient compared to young aged breast cancer patient is remains ...cancer molecular subtype has distribution and prognostic effect ...
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<p>Molecular subtype classification of papillary renal cell cancer using miRNA expression</p>
... However, the roles of miRNAs in constructing new subtypes of KIRP remain to be explored. In the present study, we performed unsupervised clustering using aberrant miRNA expression data to analyze molecular ...
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Metabolic syndrome-breast cancer link varies by intrinsic molecular subtype
... Results: Data analysis suggests that MS per se represents a modifiable risk factor for BC in postmenopausal [OR 6.28 (95% CI 2.79-14.11) p < 0.00001]. MS per se prevalence is higher among Luminal breast cancers in ...
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Breast cancer laterality and molecular subtype likely share a common risk factor
... of molecular subtypes with different risk factors were ...in molecular subtypes within ...of molecular subtypes and estimate ORs and 95% CIs for the correlation between risk factors and each ...
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Is the future of personalized therapy in triple-negative breast cancer based on molecular subtype?
... MEK inhibitors appear to be a promising agents in ML-TNBC because the ERK1/2 pathway is overexpressed in this subtype [5]. If only 2% and 5% of all breast cancers have BRAF and KRAS mutations, respectively, a ...
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ABC transporter activity linked to radiation resistance and molecular subtype in pediatric medulloblastoma
... As molecular sub-typing data was unavailable for the majority of our patient cohort, we turned to a large and well annotated public medulloblastoma dataset for further investigations ...significant ...
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DNA methylation data-based molecular subtype classification and prediction in patients with gastric cancer
... in molecular level make the same patho- logical staging with the same treatment scheme get dif- ferent treatment results [9, ...the molecular mechanisms of the occurrence, progres- sion and metastasis of ...
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Molecular epidemiology of 58 new African human T-cell leukemia virus type 1 (HTLV-1) strains: identification of a new and distinct HTLV-1 molecular subtype in Central Africa and in Pygmies.
... thus allowing better phylogenetic discrimination among highly related strains than with gp21 sequence data (55). (ii) Despite the fact that only 38 complete HTLV-1 and STLV-1 LTR sequences were available compared to more ...
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Luminal B tumors are the most frequent molecular subtype in breast cancer of North African women: an immunohistochemical profile study from Morocco
... Background: Breast cancer may be classified into luminal A, luminal B, HER2+/ER-, basal-like and normal-like subtypes based on gene expression profiling or immunohistochemical (IHC) characteristics. The aim of our study ...
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Comparison of molecular subtype distribution in triple negative inflammatory and non inflammatory breast cancers
... appropriate molecular-based therapies. In breast cancer, five molecular subtypes have been re- peatedly described in non-IBC [30-32], and these subtypes have been strongly associated with clinical outcome ...
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Coexpression analysis of CD133 and CD44 identifies Proneural and Mesenchymal subtypes of glioblastoma multiforme
... pipeline at http://gdac.broadinstitute.org/. Patients that were profiled on both RNAseq and Agilent platforms were removed from the Agilent and retained in the RNAseq dataset. An independent GBM data set was accessed ...
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High expression of NR1D1 is associated with good prognosis in triple negative breast cancer patients treated with chemotherapy
... Results: One hundred thirty-nine of these samples exhibited high NR1D1 expression, mostly in the nucleus of breast cancer cells. NR1D1 expression correlated significantly with histological grade and estrogen receptor ...
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Genome driven integrated classification of breast cancer validated in over 7,500 samples
... in subtype assignment for cell lines ac- cording to the origin of the data for all ...into molecular subtypes. Details of molecular subtype assignment for each cell line by data source are ...
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Thesis
... The METS-processed data is marked with known PAM50 molecular subtype (see Figure 6 legend). Comparing the clustering between the left panel (unprocessed tumor sample) and the right panel (METS processed ...
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Breast cancer in Ethiopia: evidence for geographic difference in the distribution of molecular subtypes in Africa
... A subtype was the most prevalent followed by luminal B subtype, Triple Negative, and HER2-enriched derived ...common molecular subtype (43–82%) of breast cancer ...common molecular ...
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... Overall, our results on 217 invasive BCs indicate that ALDH1 is an important, poor prognostic factor associated with high histological grade, ER/PR negativity and HER2 pos- itivity. We observed a significant correlation ...
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Structural Comparison of Diverse HIV-1 Subtypes using Molecular Modelling and Docking Analyses of Integrase Inhibitors
... At present, first-line antiretroviral regimens for HIV-1 are expected to include the INSTI DTG according to World Health Organisation (WHO) recommendations [10], because it has been shown to possess a higher genetic ...
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