monocarboxylate transport
A Novel Monocarboxylate Transporter 8 Gene Mutation as a Cause of Severe Neonatal Hypotonia and Developmental Delay
... 7. Dumitrescu AM, Liao XH, Best TB, Brockmann K, Refetoff S. A novel syndrome combining thyroid and neurological abnor- malities is associated with mutations in a monocarboxylate transporter gene. Am J Hum Genet. ...
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Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation
... Cancer cells robustly expel lactate produced through enhanced glycolysis via monocarboxylate transporters (MCTs) and maintain alkaline intracellular pH. To develop a novel therapeutic strategy against multiple ...
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Monocarboxylate transporter 1 and monocarboxylate transporter 4 in cancer-endothelial co-culturing microenvironments promote proliferation, migration, and invasion of renal cancer cells
... [13]. Monocarboxylate transporters (MCTs) are a family of proteins that regulate glycolysis, and they are responsible for transporting lactate inside and outside of ...
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Intratumoral reciprocal expression of monocarboxylate transporter 4 and glypican 3 in hepatocellular carcinomas
... Liver cancer is the leading cause of cancer death world- wide and is the second leading cause of cancer death in men [1]. As hepatocellular carcinoma (HCC) is the most common liver malignancy, the molecular mechanism of ...
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Programmed cell death of primordial germ cells in Drosophila is regulated by p53 and the Outsiders monocarboxylate transporter
... Primordial germ cell development uses programmed cell death to remove abnormal, misplaced or excess cells. Precise control of this process is essential to maintain the continuity and integrity of the germline, and to ...
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Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in β cells
... Previous investigations revealed low activities of lactate dehydrogenase (LDH) and plasma mem- brane monocarboxylate transporters (MCT) in the pancreatic β cell. In this study the significance of these ...
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Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters
... normal human astrocytes expressing mutant or wild-type IDH1 (NHAIDHmut and NHAIDHwt). Our results indicate that hyperpolarized lactate production is reduced in NHAIDHmut cells compared to NHAIDHwt. This reduction was ...
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Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8
... monocarboxylate transporter 8 (MCT8; SLC16A2) lead to severe forms of psychomotor retardation combined with imbalanced thyroid hormone serum levels. The MCT8-null mice described here, however, developed without ...
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Monocarboxylate Transporters and Lactate Metabolism in Equine Athletes: A Review
... but transport other monocar- boxylic acids, such as pyruvate, volatile fatty acids, and ketone bodies, as ...the transport is electroneutral; one monocar- boxylate anion is transported together with a ...
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Monocarboxylate transporter 1 contributes to growth factor- induced tumor cell migration independent of transporter activity
... that monocarboxylate transporters (MCTs) are important factors associated with EGF- and HGF-induced cancer cell ...the transport of monocarboxylates, such as lactate and pyruvate, as well as ketone bodies ...
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Original Article Expression of monocarboxylate transporters in gallbladder cancer and their prognostic clinical significance
... Abstract: Objective: Gallbladder cancer (GBC), one of the most common and aggressive malignancies of the biliary duct, is associated with a dismal prognosis. Monocarboxylate transporters (MCTs) have been reported ...
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<p>Inhibition Of Monocarboxylate Transporter 1 In Spinal Cord Horn Significantly Reverses Chronic Inflammatory Pain</p>
... of monocarboxylate transporters (MCTs) are closely related to cellular metabolism and synaptic plasticity, and it is also reported that MCTs participate in chronic in fl ammatory ...
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The altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters
... MCTs play a vital role in monocarboxylate transport and pH homeostasis [7]. Because MCT1 is bidirectional, its inhibition not only causes a decrease in intracellular pH and eventually leads to cell death, ...
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Insights into molecular properties of the human monocarboxylate transporter 8 by combining functional with structural information
... defined spatial distance to each other of around 14-15 Å (figure 7A). Assuming a certain degree of analogy in T3 binding, such specific residues, their biochemical prop- erties and their arrangement in the binding ...
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Lactate, a putative survival factor for myeloma cells, is incorporated by myeloma cells through monocarboxylate transporters 1
... Lactate is transported through monocarboxylate trans- porters (MCTs), which are composed of 14 members and encoded by the SLC16 gene family. Among the MCTs, only four isoforms (MCT1–MCT4) are known as ...
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Sepsis associated hyperlactatemia
... Abbreviations CoA: Coenzyme A; DCA: Dichloroacetate; DO2: Oxygen delivery; HIF: Hypoxia-inducible factor; LDH: Lactate dehydrogenase; MCT: Monocarboxylate transport protein; mLOC: mitoch[r] ...
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Brain functioning under acute hypothermic stress supported by dynamic monocarboxylate utilization and transport in ectothermic fish
... the transport of lactate in the mammalian brain ...trans-membrane transport of relevant monocarboxylic acids, such as lactate, pyruvate and ketone bodies ...lactate transport mechanism of MCT1 has ...
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MEMBRANE PERMEABILITY AND UTILIZATION OF l LACTATE AND PYRUVATE IN CARP RED BLOOD CELLS
... parallel transport systems, a monocarboxylate carrier and a band 3 anion exchanger, and also by non-ionic diffusion (see Deuticke, 1982, 1989), makes a detailed analysis ...the monocarboxylate ...
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Repurposing Dichloroacetate for the Treatment of Multiple Myeloma
... This chapter has identified a series of factors that can contribute to the sensitivity to DCA of MM cells, but there are more components that could potentially affect the sensitivity, which can be studied in the future. ...
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Molecular functions and clinical impact of thyroid hormone-triggered autophagy in liver-related diseases
... 4: Monocarboxylate transporter 4; mTOR: Mammalian target of rapamycin; NAFLD: Non-alcoholic fatty liver disease; NCoR1: Nuclear receptor corepressor 1; NQO1: NAD(P)H, dehydrogenase quino[r] ...
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