Monocarboxylate transporter
A Novel Monocarboxylate Transporter 8 Gene Mutation as a Cause of Severe Neonatal Hypotonia and Developmental Delay
... Monocarboxylate transporter 8 acts as a specific cell membrane transporter for thyroxine and especially triiodothy- ronine into target ...The monocarboxylate transporter 8 gene resides ...
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Monocarboxylate transporter 1 promotes classical microglial activation and pro-inflammatory effect via 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3
... regulators, monocarboxylate transporter 1 (MCT1), MCT4, and pro-glycolytic enzyme 6- phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3), were specifically increased in LPS-stimulated primary ...
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Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in β cells
... In studies using whole rat or mouse islets, it has been observed that pyruvate cannot mimic the effect of glu- cose on insulin secretion, despite active metabolism (11–13). This has been referred to as the “pyruvate par- ...
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Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8
... monocarboxylate transporter 8 (MCT8; SLC16A2) lead to severe forms of psychomotor retardation combined with imbalanced thyroid hormone serum levels. The MCT8-null mice described here, however, developed ...
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Programmed cell death of primordial germ cells in Drosophila is regulated by p53 and the Outsiders monocarboxylate transporter
... Primordial germ cell development uses programmed cell death to remove abnormal, misplaced or excess cells. Precise control of this process is essential to maintain the continuity and integrity of the germline, and to ...
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Intratumoral reciprocal expression of monocarboxylate transporter 4 and glypican 3 in hepatocellular carcinomas
... Liver cancer is the leading cause of cancer death world- wide and is the second leading cause of cancer death in men [1]. As hepatocellular carcinoma (HCC) is the most common liver malignancy, the molecular mechanism of ...
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Monocarboxylate transporter 1 and monocarboxylate transporter 4 in cancer-endothelial co-culturing microenvironments promote proliferation, migration, and invasion of renal cancer cells
... Some signal transduction pathways contribute to the Warburg effect and the metabolic phenotype of cancer cells. For example, signaling initiated by growth factors results in the activation of PI3K/Akt and Ras via RTKs ...
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<p>Inhibition Of Monocarboxylate Transporter 1 In Spinal Cord Horn Significantly Reverses Chronic Inflammatory Pain</p>
... of monocarboxylate transporters (MCTs) are closely related to cellular metabolism and synaptic plasticity, and it is also reported that MCTs participate in chronic in fl ammatory ...
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Insights into molecular properties of the human monocarboxylate transporter 8 by combining functional with structural information
... Naturally occurring mutations in MCT8 provide mole- cular insights into protein regions important for protein folding and the switching mechanism during substrate transport. This was shown here by the assignment of ...
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Monocarboxylate transporter 1 contributes to growth factor- induced tumor cell migration independent of transporter activity
... MCT1 expression has been correlated with decreased survival and advanced stages of progression in cancer patients [24–26]. Specifically, the transporter activity of MCT1 has been demonstrated to contribute to ...
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Repurposing Dichloroacetate for the Treatment of Multiple Myeloma
... This chapter has identified a series of factors that can contribute to the sensitivity to DCA of MM cells, but there are more components that could potentially affect the sensitivity, which can be studied in the future. ...
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Molecular functions and clinical impact of thyroid hormone-triggered autophagy in liver-related diseases
... 4: Monocarboxylate transporter 4; mTOR: Mammalian target of rapamycin; NAFLD: Non-alcoholic fatty liver disease; NCoR1: Nuclear receptor corepressor 1; NQO1: NAD(P)H, dehydrogenase quino[r] ...
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Original Article Expression of monocarboxylate transporters in gallbladder cancer and their prognostic clinical significance
... a preference for T3 that is ubiquitously ex- pressed in the intestines, kidneys, liver, mus- cle, and placenta [17]. MCT8 is also a high- affinity thyroid hormone transporter [18]. MCT6 has been reported to ...
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Expression of the Genes OsNRT1 1, OsNRT2 1, OsNRT2 2, and Kinetics of Nitrate Uptake in Genetically Contrasting Rice Varieties
... OsNRT2.1 transporter is responsible for absorption of up to 75% of the available nitrate in Arabidopsis thaliana, while the huge differences regarding the induction response levels of the NRT2s, as observed for ...
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cocaine piperidine based analogs sar 2 pdf
... The synthesis and monoamine transporter activity of additional members of a series of 3,4- disubstituted piperidines (truncated analogues of the WIN series) are described. All members of this series were prepared ...
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Expression and regulation of drug transporters in vertebrate neutrophils
... In the zebrafish, we searched for the orthologues of the human gene family members and further analysed the paralogues yet to be assigned to the family by manual analysis of the gene trees present in Ensembl. This uncov- ...
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Sotagliflozin, the first dual SGLT inhibitor: current outlook and perspectives
... Sotagliflozin is a dual sodium–glucose co-transporter-2 and 1 (SGLT2/1) inhibitor for the treatment of both type 1 (T1D) and type 2 diabetes (T2D). Sotagliflozin inhibits renal sodium–glucose co-transporter ...
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The translational expression of ABCA2 and ABCA3 is a strong prognostic biomarker for multidrug resistance in pediatric acute lymphoblastic leukemia
... Keywords: ABCA2 transporter, ABCA3 transporter, multidrug resistance, childhood acute lymphoblastic leukemia, molecular docking, tertiary structure.. Introduction.[r] ...
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Genetic Processes of Iron and Zinc Accumulation in Edible Portion of Crops and Their Agro-Biofortification: A Review
... The strategy I mechanism included proton extrusion to solubilize Fe (III) in the soil, reduction of the solubilized Fe (III) by a membrane-bound Fe (III) chelate reductase and transport of the resulting Fe (II) into the ...
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DRD4 and DAT1 in ADHD: Functional neurobiology to pharmacogenetics
... The homozygosity for 10-repeat allele at dopamine transporter gene and dopamine transporter density in Korean children with attention deficit hyperactivity disorder: Relating to treat[r] ...
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