Monoclonal Antibodies
Chimeric Filoviruses for Identification and Characterization of Monoclonal Antibodies
... genes encoding major protective antigens, such as the glycopro- tein (GP), which is the sole envelope protein of filoviruses. GP is expressed as a precursor protein that is cleaved posttranslationally to GP1 and GP2 ...
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Glycosylation analysis of therapeutic monoclonal antibodies
... [10]. Monoclonal antibodies used in the treatment of cancers were primarily designed to target tumour antigens mainly involved in growth and proliferation of cancer cells and the main mechanism of action ...
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Monoclonal Antibodies in Rheumatic Diseases
... of antibodies which may affect safety and efficacy. Antibodies can neutralize the action of these drugs and may cause hypersensitivity ...human monoclonal antibodies; use of concomitant ...
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Pharmacokinetics of Therapeutic Monoclonal Antibodies Used in Oncology
... of monoclonal antibodies in tumor tissues is determinant for their ...The antibodies target proteins expressed on the membrane of tumors cells, except bevacizumab that binds the circulating cytokine ...
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Monoclonal Antibodies for the Treatment of Multiple Myeloma: An Update
... using monoclonal antibodies (mAbs), while long in development, began to reap success with the identification of CD38 and SLAMF7 as suitable targets for development, culminating in the 2015 FDA approval of ...
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The technique for the production of monoclonal antibodies
... mouse monoclonal antibodies have been modified by linking rodent variable regions and human constant regions (chimeric antibodies) or grafting the complementarity- determining region gene segments ...
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A search for monoclonal antibodies for the immunolocalisation of colorectal cancer.
... when monoclonal antibodies are used in immunoscintigraphy or ...of monoclonal antibodies, each recognising different antigenic determinants with different levels o f expression to achieve ...
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Interactions of monoclonal antibodies with an influenza A virus
... with monoclonal antibodies (MAbs) to a single antigenic ...of antibodies to each antigenic site; hence it is difficult to envisage how antigenic drift mutants arise under these selection pressures ...
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MONOCLONAL ANTIBODIES TO HUMAN ALPHA-FETOPROTEIN
... produced monoclonal antibodies for AFP and confirmed that both of these antibodies were not able to react with proteins presented in normal adult ...
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Therapeutic Applications of Monoclonal Antibodies in Multiple Sclerosis
... 12 antibodies result in decreasing the EAE. C. Monoclonal antibodies targeting B cells The role of B cells has long been debatable in MS pathogenesis; there are some signs (B cells existence, plasma ...
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Towards Dewetting Monoclonal Antibodies for Therapeutical Purposes
... of monoclonal antibodies (against cellular receptors) equipped with lipophilic/hydrophobic ...these antibodies DEMA (DEwetting Monoclonal ...link monoclonal targets, their artificial ...
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Monoclonal Antibodies
... the antibodies will quickly get to ...twice. Monoclonal antibodies are groups of cells (antibodies) that are produced from a single ancestral cell by repeated cellular ...have ...
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Use of Monoclonal Antibodies To Identify Serotypes of Enterovirus Isolates
... available monoclonal antibodies for polioviruses, coxsackieviruses type B, and six serotypes of com- monly circulating ...specific monoclonal antibodies were applied was 73% for polioviruses, ...
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Monoclonal antibodies as diagnostics; an appraisal
... for antibodies as tools for research for prevention, detection and treatment of diseases, vaccine production, antigenic characterization of pathogens and in the study of genetic regulation of immune responses and ...
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Production and Characterization of Monoclonal Antibodies to Rat Angiotensinogen
... Inhibition of the Renin-Angiotensinogen Reaction The ability of monoclonal antibodies to inhibit the renin-angiotensinogen reaction was tested on a pool of binephrectomized rat plasma. Purified immunoglobu- ...
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Production of Monoclonal Antibodies
... Although monoclonal antibodies are pow- erful tools, it cannot be overemphasized that a major commitment is necessary to identify a MAb of interest. The work is tedious and labor intensive. Moreover, in ...
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Generating Monoclonal Antibodies
... Figure 3 outlines the steps in the production of monoclonal antibodies. Animals are injected with an antigen preparation. Once a good humoral response (titer) has appeared in the immunized animal and an ...
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Varicella-zoster viral glycoproteins analyzed with monoclonal antibodies.
... To obtain preliminary information on the synthesis of viral polypeptides in cells infected with cell-free virus, the infected cultures and uninfected control cultures were labeled at var[r] ...
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Monoclonal antibodies specific for dengue virus type 3
... Mouse ascites fluid obtained by using clone 31 contained the highest HI titer tested against dengue-3 and demonstrated negligible cross-reactive antibody activity.. Immunofluorescent sta[r] ...
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Monoclonal Antibodies Handling and Administration Risk Management
... MABs are known for their sensitizing properties. Long term exposure at low dose may lead to the formation of antibodies which may cause allergic reactions [15]. The Langford & al. classification method ...
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