monocyte-derived dendritic cell
Membranes, molecules and biophysics: enhancing monocyte derived dendritic cell (MDDC) immunogenicity for improved anti cancer therapy
... of dendritic cells in vivo and how monocyte derived dendritic cells may be manipulated ex vivo to provide more robust, patient-specific ...
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Clinical significance of monocyte derived dendritic cell activation in patients with acute coronary syndrome
... reaction. Dendritic cells (DCs) expressing various Toll-like re- ceptors (TLRs) have been observed in atherosclerotic lesions, however, the clinical significance of DCs in pathogenesis of ACS has not been ...
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Nuclear Receptor Signaling Inhibits HIV-1 Replication in Macrophages through Multiple trans-Repression Mechanisms
... monocytic cell lines and primary monocyte-derived macrophages (MDMs) through the induc- tion of an as-yet-unidentified factor (21, 57, 77, ...phoid cell lines (78, 82, 106, 133) but not in ...
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Evaluation of Feline Monocyte-Derived Dendritic Cells Loaded with Internally Inactivated Virus as a Vaccine against Feline Immunodeficiency Virus
... Because MDCs were generated from PBMCs, there was a natural limit to the number of cells that could be obtained. Since freezing decreases the number of viable cells available, we chose to generate fresh MDCs every time ...
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Mucosal Tissue Tropism and Dissemination of HIV-1 Subtype B Acute Envelope-Expressing Chimeric Virus
... to monocyte-derived macrophages, or dendritic cells ...cyte-derived dendritic cells to T cells, chimeric virus from acute Envs achieved significantly lower titers compared to chronic ...
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Antitumor Efficacy of Human Monocyte-Derived Dendritic Cells: Comparing Effects of two Monocyte Isolation Methods
... [7]. Monocyte-derived DCs (MoDCs) are by far the most used in recent DC vaccine formulations [8] ...where cell purity is not a major concern [9, 10]. To obtain high cell purity, the ...
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Infection of human monocyte derived dendritic cells by ANDES Hantavirus enhances pro inflammatory state, the secretion of active MMP 9 and indirectly enhances endothelial permeability
... as cell to cell junction proteins including VE-cadherin, PECAM-1, occludin, claudins, as well as soluble factors, including, IL-1b, TNF-a, VEGF, and Kinins ...
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New application of anti-TLR monoclonal antibodies: detection, inhibition and protection
... conventional dendritic cell; BM-MC: bone marrow-derived macrophage; BM-pDC: bone marrow-derived plasmacytoid dendritic cell; CCR2: C-C chemokine receptor type 2; D34A mutation: ...
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Complementary Antiviral Efficacy of Hydroxyurea and Protease Inhibitors in Human Immunodeficiency Virus-Infected Dendritic Cells and Lymphocytes
... in dendritic cells because preclinical testing of antiretroviral drugs has been limited predominantly to T cells and ...in monocyte-derived dendritic cells and in ...from ...
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Generation of Mature Monocyte-Derived Dendritic Cells in the Presence of Heparin and Monocyte Conditioned Medium: Phenotypic and Functional Comparison
... Background: Dendritic cells (DC) induce tumor or pathogen-specific T cell responses in ...autologous monocyte-conditioned medium (MCM), with heparin for their ability to promote uniformly mature DC ...
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Subviral Dense Bodies of Human Cytomegalovirus Stimulate Maturation and Activation of Monocyte-Derived Immature Dendritic Cells
... Having shown that DB treatment leads to maturation and activation of DC, we next tested if this resulted in an enhanced capacity of these cells to present antigen and to stimulate au- tologous T cells in IFN-␥ ...
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Severe Acute Respiratory Syndrome Coronavirus Fails To Activate Cytokine-Mediated Innate Immune Responses in Cultured Human Monocyte-Derived Dendritic Cells
... and dendritic cells (DCs). In all cell types, SCV-specific subgenomic mRNAs were seen, whereas no expression of SCV proteins was ...host cell cytokine gene expression in human macrophages and ...
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DIFFERENTIATION OF MONOCYTE DERIVED DENDRITIC CELLS IN SERUM FREE CONDITIONS
... Phenotypical cell markers and values of accessory activity after four and eight days of culture in MCDB-302 or medium 80/20 containing 20% human ...the cell popUlations stain positive with the monoclonal ...
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SAMHD1 Limits HIV-1 Antigen Presentation by Monocyte-Derived Dendritic Cells
... postentry step (7, 8). SAMHD1 is a dNTP hydrolase that depletes the intracellular pool of dNTPs in myeloid cells, limiting the avail- ability of substrates for viral DNA synthesis (9–12). SAMHD1 also binds and degrades ...
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Fibroblast and T cells conditioned media induce maturation dendritic cell and promote T helper immune response
... 12 and IL-10 produced by matured DCs, IFN-γ, and IL-4 cytokine were produced by primed T cells as represent- atives of type 1 and type 2 cytokine patterns, respectively. We examined cytokine profiles produced by ...
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Dendritic Cells Activate and Mature after Infection with Mycobacterium tuberculosis
... human dendritic cells and ...human monocyte derived DC phagocytose ...important cell in the early response to TB ...human monocyte-derived dendritic cells in vitro and ...
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Alteration of T cell immunity by lentiviral transduction of human monocyte derived dendritic cells
... of cell-surface marker expression by flow cytometry, we incubated DCs for 10 min with normal mouse serum and then 30 min with fluorochrome-conju- gated anti-human monoclonal ...
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Nsp1α of Porcine Reproductive and Respiratory Syndrome Virus Strain BB0907 Impairs the Function of Monocyte-Derived Dendritic Cells via the Release of Soluble CD83
... PRRSV proteins are involved in the modulation of the immune response (3, 7). PRRSV Nsp1 ␣ plays multiple roles in supporting viral escape from immune surveillance (11–13, 15, 17, 18). Nsp1 ␣ suppresses the ability of ...
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HIV-1 Envelope Glycan Moieties Modulate HIV-1 Transmission
... (PBLs), monocyte-derived macrophages (MDMs), and monocyte-de- rived dendritic cells (MoDCs), we examined the impact of Env glycan moieties (high-mannose versus complex glycan) on the major ...
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SAMHD1 Restricts HIV-1 Cell-to-Cell Transmission and Limits Immune Detection in Monocyte-Derived Dendritic Cells
... hematopoietic cell types (peripheral blood mononuclear cells and pDCs) ...on cell-free HIV-1 infection and sensing by ...of cell-free HIV-1 by ...
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