Monocyte/Macrophage
The monocyte-macrophage-mast cell axis in dengue pathogenesis
... Both innate and adaptive immune responses to DENV play significant roles in protection against DENV, but can also elicit pathological responses which may worsen disease [2, 7]. Understanding the mechanisms that regu- ...
10
Molecular mechanisms of HIV 1 persistence in the monocyte macrophage lineage
... the monocyte-macrophage lineage may contribute to the for- mation of reservoirs to a larger extent and may partici- pate in viral ...the monocyte- macrophage lineage, but not for non dividing ...
16
Plasmodium falciparum PfEMP1 modulates monocyte/macrophage transcription factor activation and cytokine and chemokine responses
... Monocytes are important sources of cytokines and chemokines in human malaria infection (5, 8). We found that the inhibitory effect of VAR2CSA PfEMP1 observed in macrophages also translated to human primary monocytes, ...
14
Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis
... activated macrophages in the pathogenesis of SSc. Mac- rophages have been thought to be particularly activated in patients with skin disease including SSc and are poten- tially important sources for fibrosis-inducing ...
10
Innate immunity and monocyte-macrophage activation in atherosclerosis
... of monocyte-macrophages infiltrating the plaque [12] and their location at plaque rupture-sensitive sites (such as the fibrous cap and areas of erosion [13,14]) is related to plaque ...[13]. Macrophage ...
17
Regulation of HIV 1 transcription in cells of the monocyte macrophage lineage
... the monocyte-macrophage lineage play an impor- tant role in the transmission and pathogenesis of HIV [10- ...into monocyte-derived macrophages (MDMs) and may form a long-lived reservoir for the virus ...
24
Hepatitis A Virus Suppresses Monocyte-to-Macrophage Maturation In Vitro
... To analyze the pathogenetic mechanism of hematopoietic dysregulation associated with hepatitis A virus (HAV) infections, we studied the influence of HAV on monocyte (MO)-to-macrophage (MAC) maturation in ...
7
Original Article Increased circulating macrophage-colony stimulating factor and monocyte chemoattractant protein-1 are predictors of in-hospital events in Chinese patients with unstable angina pectoris
... Background: Macrophage colony stimulating factor (MCSF) and monocyte chemoattractant protein-1 (MCP-1) play an important role in the activation of monocyte resulting in the onset and progression of ...
6
Bordetella Adenylate Cyclase Toxin Inhibits Monocyte to Macrophage Transition and Dedifferentiates Human Alveolar Macrophages into Monocyte like Cells
... Preventing monocyte-to-macrophage transition at the site of infection is thus likely to play a role in the colonization capacity of ...differentiated macrophage cells can be dedifferentiated back to ...
16
Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases
... Figure 2 Human MC and M ϕ differentiation, and distinct subset functions. Human CD14 ++ CD16 - classical MCs leave the bone marrow in a CC-chemokine receptor 2 (CCR2)-dependent manner. In the steady state, classical MCs ...
9
Epigenetic dynamics of monocyte-to-macrophage differentiation
... during monocyte-to-macrophage differentiation is a rapid, active process catalyzed by TET enzymes, as shown by increasing levels of 5hmC lev- els in the first 12 h of differentiation and the inhibition of ...
17
Human cytomegalovirus infection of the monocyte/macrophage lineage in bone marrow.
... Because our data suggested that undifferentiated monocytes could be infected with HCMV in vitro, we asked whether endogenous HCMV DNA could be detected in bone marrow progenitor cells of[r] ...
5
Recent advances in the treatment of skin involvement in systemic sclerosis
... and 4 cases were additionally treated with immunosup- pressants during the safety follow-up period (one patient at week 9 and three patients at week 11). mRSS was sig- nificantly improved in both groups at week 11 and 17 ...
6
Comprehensive gene expression meta-analysis identifies signature genes that distinguish microglia from peripheral monocytes/macrophages in health and glioma
... predominant macrophage cell population; however, under conditions of blood-brain barrier leakage, peripheral monocytes/macrophages can infiltrate the brain and participate in CNS disease ...peripheral ...
18
Oral contraceptives modify DNA methylation and monocyte-derived macrophage function
... Figure 3 Activation status of estrogen receptors. Representative western blot for estrogen receptor a phosphorylation (A) and representative western blot with corresponding densitometric analysis of estrogen receptor b ...
11
Impact of VIP and cAMP on the regulation of TNF α and IL 10 production: implications for rheumatoid arthritis
... in monocyte/macrophage cultures stimulated with LPS may have been due to a high level of endogenous intrinsic phosphodiesterase activity, resulting in a short-lived cAMP in these cell ...
12
Case Report Clinical manifestation, pathologic findings and genotyping of adult-onset Still’s disease: report of a fatal case
... for monocyte counts was of particular interest, since we know monocyte-macrophage activation usually played a key role in symptoms onset of rheu- matic diseases, and furthermore, no other ...
8
Apoptosis of human intestinal epithelial cells after bacterial invasion
... mouse monocyte-macrophage cell lines following bacterial in- ...mouse monocyte- macrophage cell lines within 1–2 h of infection (17–19), although Shigella did not induce apoptosis of human ...
10
Expression of macrophage procoagulant activity in murine systemic lupus erythematosus
... lymphocytes or lymphocyte supernatants from 5-mo-old mice. Plasma from 5-mo-old but not from 1-mo-old mice was able to induce the production of the lymphokine by cells from 1-mo- old animals. This lymphokine was not ...
8
Effect of hematopoietic growth factors on human blood monocytes/macrophages in in vitro culture.
... The addition of macrophage CSF, granulocyte-macrophage CSF, and granulocyte CSF and interleukin-6 and interleukin-3 growth factors to monocyte/macrophage cultures induced morphological c[r] ...
6